预约演示
更新于：2026-08-03
Bilastine
比拉斯汀
更新于：2026-08-03
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
最高研发阶段(中国)撤市 |
特殊审评- |
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结构/序列
分子式C28H37N3O3 |
InChIKeyACCMWZWAEFYUGZ-UHFFFAOYSA-N |
CAS号202189-78-4 |
关联
141
项与 比拉斯汀 相关的临床试验CTR20261020
江苏悦兴药业有限公司持有的比拉斯汀片（20 mg）与FAES FARMA, S.A.为持证商的比拉斯汀片（20 mg）在中国健康试验参与者中进行的随机、开放、单剂量、两序列、两周期、空腹状态下的生物等效性研究
CTIS2024-519550-36-00
International multicentre, open-label, phase IV clinical trial to evaluate the efficacy, safety and effect on quality of life of bilastine in children with allergic rhinoconjunctivitis
CTR20260777
江苏联环药业股份有限公司研制的比拉斯汀片（20 mg）与FAES FARMA, S.A.为持证商的比拉斯汀片（20 mg）在中国健康研究参与者中进行的随机、开放、单剂量、两序列、两周期、空腹状态下的生物等效性研究
100 项与 比拉斯汀 相关的临床结果
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100 项与 比拉斯汀 相关的转化医学
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100 项与 比拉斯汀 相关的专利（医药）
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305
项与 比拉斯汀 相关的文献（医药）2026-08-01APPETITE
Interoceptive-based interventions for eating disorders: A systematic review
Review
作者: Barca, Laura ; Diana, Salvatore M
Disruptions in interoception, the awareness of internal bodily signals, are strongly linked to various psychological and physiological conditions, including eating disorders (EDs) such as anorexia nervosa, bulimia nervosa, and binge-eating disorder. Despite growing evidence that altered interoceptive processing is central to EDs, the use of interoceptive-based interventions (IBIs) in this population remains under-explored. This systematic review aims to evaluate the application and efficacy of IBIs in the treatment of eating disorders. A comprehensive search of PsycINFO, Web of Science, PubMed, and Scopus was conducted, adhering to PRISMA guidelines. We included randomized controlled trials, quasi-experimental studies, case series, and single-case studies involving individuals with ED diagnoses and interventions incorporating interoceptive elements (e.g., mindfulness, biofeedback, interoceptive exposure). The primary outcomes evaluated were changes in eating disorder symptom severity. Secondary outcomes included changes in interoceptive functioning and affective variables such as emotional regulation, anxiety, and stress. Thirteen studies, totaling 454 participants, were included in the review. Mindfulness-based interventions (MBIs) were the most common and consistently led to improvements in emotional regulation, reduced binge/compensatory behaviors, and enhanced bodily awareness. While promising, preliminary findings from studies on interoceptive exposure (IE) and biofeedback indicated potential for reducing avoidance and anxiety, particularly in patients with anorexia nervosa and binge-eating disorder. A key limitation across most studies was a high risk of bias and a lack of standardized measures for assessing interoceptive outcomes. This review provides a comprehensive synthesis of the current literature on IBIs for eating disorders, enhancing our understanding of their clinical application and highlighting critical areas for future research and refinement.
2026-05-04Expert Opinion On Drug Safety
Potential drugs for reducing the occurrence of immune checkpoint inhibitor-induced interstitial lung disease: an exploratory study using the JADER and FAERS databases
Article
作者: Koseki, Takenao ; Kondo, Masashi ; Hatano, Masakazu ; Utsunomiya, Ayaka ; Yamada, Shigeki ; Imaizumi, Kazuyoshi
BACKGROUND:
Immune checkpoint inhibitors (ICIs) play a central role in cancer immunotherapy. However, the occurrence of immune-related adverse events, especially ICI-induced interstitial lung disease (ICI-ILD), is life-threatening and affects the effectiveness of ICI treatment. This study aimed to explore potential drugs to mitigate ICI-ILD occurrence using data from the Japanese Adverse Drug Event Report (JADER) and the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS [JAPIC AERS]).
RESEARCH DESIGN AND METHODS:
We investigated concomitant drugs that reduce ILD associated with four ICIs - nivolumab, pembrolizumab, atezolizumab, and durvalumab - across the JADER and FAERS databases. Subsequently, the identified common concomitant drugs that reduce the occurrence of ICI-ILD were detected and analyzed.
RESULTS:
We found omega-3 fatty acids, loperamide, and amlodipine as common concomitant drugs that reduced ICI-ILD occurrence in both the JADER and FAERS databases. Omega-3 fatty acids reportedly have many effects in animal models of drug-induced ILD, including their association with ILD in humans and anti-inflammatory effects against ICI-ILD. However, loperamide and amlodipine reportedly have minimal effects against ILD, thereby necessitating further evaluation.
CONCLUSION:
Omega-3 fatty acids have emerged as potential agents for reducing ICI-ILD occurrence, as evidenced by findings from two different pharmacovigilance databases.
2026-05-01Journal of Allergy and Clinical Immunology-In Practice
Efficacy and Safety of Oral Antihistamines for Allergic Rhinitis: Network Meta-Analysis
Review
作者: Pereira, Ana Margarida ; Sousa-Pinto, Bernardo ; Thomander, Tuuli ; Silva Ribeiro, Rita A ; Valiulis, Arunas ; Pereira, Marta Soares ; Klimek, Ludger ; Marques-Cruz, Manuel ; Yepes Nuñez, Juan Jose ; Viegas, Hugo ; Perestrelo, Paula ; Ferreira, André ; Castro-Teles, João ; Ferreira-da-Silva, Renato ; Teixeira-Ferreira, Ana ; Schünemann, Holger J ; Borowiack, Ewa ; Fonseca, João A ; Bedbrook, Anna ; Chu, Alexandro W L ; Boechat, José Laerte ; Ierodiakonou, Despo ; Lourenço-Silva, Nuno ; Costa, Raquel Albuquerque ; Bousquet, Jean ; Sadowska, Ewelina ; Bognanni, Antonio ; Zuberbier, Torsten ; Duarte, Vítor Henrique ; Riera-Serra, Pau ; Vieira, Rafael José ; Gil-Mata, Sara ; Torres, Maria Inês ; Campos-Lopes, Miguel ; Pereira-Macedo, Juliana ; Cherrez-Ojeda, Ivan ; Calvi, Izabela Pera ; Ferreira-Cardoso, Henrique
BACKGROUND:
Oral H1-antihistamines (OAHs) are among the most frequently used medications for the treatment of allergic rhinitis (AR).
OBJECTIVE:
To perform a systematic review and network meta-analysis comparing the efficacy and safety of individual OAHs in patients with AR.
METHODS:
We searched 4 electronic bibliographic databases and 3 clinical trial databases for randomized controlled trials assessing adults with perennial or seasonal AR, and comparing (1) OAH versus placebo or (2) different individual OAHs. We performed a network meta-analysis on the Total Nasal Symptom Score, Total Ocular Symptom Score, Rhinoconjunctivitis Quality-of-Life Questionnaire, development of adverse events, and withdrawals due to adverse events. Certainty of evidence for comparisons involving the most clinically relevant second-generation OAHs was assessed using Grading of Recommendations, Assessment and Evaluation approach to network meta-analysis.
RESULTS:
We included 74 randomized controlled trials (21 on perennial AR and 53 on seasonal AR). Cetirizine, ebastine, bilastine, and rupatadine were among the individual medications associated with the highest efficacy for improving nasal symptoms. For other efficacy outcomes, the most efficacious interventions varied. A similar frequency of adverse events was observed among different individual second-generation OAHs, with serious adverse events being rare. For most comparisons, the certainty of evidence was rated as "low" or "very low," indicating substantial uncertainty regarding the treatment effects.
CONCLUSIONS:
Although some OAHs seem to be more efficacious than others, most of the differences between individual second-generation medications are trivial or small. In addition, we did not find any relevant differences in the safety profiles of second-generation OAHs.
100 项与 比拉斯汀 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 慢性荨麻疹 | 加拿大 | 2016-12-02 | |
| 皮炎 | 日本 | 2016-09-28 | |
| 湿疹 | 日本 | 2016-09-28 | |
| 瘙痒 | 日本 | 2016-09-28 | |
| 瘙痒 | 日本 | 2016-09-28 | |
| 过敏性鼻炎 | 日本 | 2016-09-28 | |
| 过敏性鼻炎 | 日本 | 2016-09-28 | |
| 季节性过敏性鼻炎 | 加拿大 | 2016-04-21 | |
| 过敏性鼻结膜炎 | 奥地利 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 比利时 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 保加利亚 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 塞浦路斯 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 捷克 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 丹麦 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 爱沙尼亚 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 芬兰 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 法国 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 德国 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 希腊 | 2010-09-08 | |
| 过敏性鼻结膜炎 | 匈牙利 | 2010-09-08 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 皮疹 | 临床3期 | 立陶宛 | - | 2021-11-26 |
| 变应性结膜炎 | 临床3期 | 美国 | 2018-04-07 | |
| 常年性变应性鼻炎 | 临床3期 | - | 2004-05-01 | |
| 季节性过敏性结膜炎 | 临床2期 | 美国 | 2007-12-01 | |
| 鼻结膜炎 | 临床2期 | 加拿大 | 2007-10-01 |
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临床结果
临床结果
适应症
分期
评价
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| - | 288 | 餘築鑰構選鹹夢鑰鬱選(鬱衊遞鏇製壓夢構窪簾) = 網築簾築鏇淵獵鏇醖願 鹽窪糧選蓋糧糧觸襯齋 (顧簾獵觸遞膚鬱鬱窪網 ) | 非劣 | 2023-06-26 | |||
餘築鑰構選鹹夢鑰鬱選(鬱衊遞鏇製壓夢構窪簾) = 簾淵積願窪鬱鏇鹽醖構 鹽窪糧選蓋糧糧觸襯齋 (顧簾獵觸遞膚鬱鬱窪網 ) | |||||||
临床3期 | 228 | (Bilastine Ophthalmic Solution 0.6%) | 鬱顧網醖構鏇選憲願夢(艱鑰壓衊觸選築襯構獵) = 蓋選鹹鑰鬱簾窪簾選構 壓衊齋鑰醖願壓鏇鬱鏇 (鹽糧鹽構餘鹹構選顧糧, 0.9013) 更多 | - | 2021-12-14 | ||
(Ketotifen Ophthalmic Solution 0.025% (Zaditen)) | 鬱顧網醖構鏇選憲願夢(艱鑰壓衊觸選築襯構獵) = 鹹獵廠範廠顧鏇艱餘遞 壓衊齋鑰醖願壓鏇鬱鏇 (鹽糧鹽構餘鹹構選顧糧, 0.9504) 更多 | ||||||
临床2期 | 121 | (Bilastine 0.2%) | 鹹廠構簾襯願壓齋積遞(壓齋壓觸襯鹹簾鑰顧觸) = 鹽積餘獵壓獵糧築簾製 醖鹽齋壓餘簾鑰淵窪鹹 (憲簾衊糧憲築鹹襯選願, 0.7809) 更多 | - | 2021-11-24 | ||
(Bilastine 0.4%) | 鹹廠構簾襯願壓齋積遞(壓齋壓觸襯鹹簾鑰顧觸) = 廠鬱鏇顧壓網積衊鹹壓 醖鹽齋壓餘簾鑰淵窪鹹 (憲簾衊糧憲築鹹襯選願, 0.9449) 更多 | ||||||
临床1期 | 一线 | 12 | Bilastine Eye Drops | 構窪願艱積膚鹽齋選選(鏇築鹹積衊衊獵鹹艱選) = 壓鹹網壓艱繭願憲壓夢 餘廠艱選範遞繭鹽鏇醖 (衊範顧網製顧餘遞醖顧 ) 更多 | - | 2020-06-01 | |
临床4期 | 454 | (Bilastine+Montelukast) | 構艱選衊餘鏇壓鹽築艱(鹽範簾範鏇積衊願糧鑰) = 餘憲遞積獵範廠夢鹽餘 鹽齋製淵衊鹹壓夢鏇餘 (鏇壓糧觸蓋壓淵衊積餘, 窪鑰選淵夢鏇簾構獵選 ~ 窪選鏇網範獵顧獵齋鏇) 更多 | - | 2019-07-12 | ||
Placebo Montelukast 10mg+Bilastine 20mg (Bilastine+Placebo Montelukast) | 夢範窪鑰築構齋衊觸範(廠構顧鑰獵鑰淵鏇鬱願) = 鏇繭壓齋窪夢獵積蓋鑰 餘廠願鹽顧願糧願醖醖 (鑰鹽壓蓋構願製獵築齋, 鑰膚蓋選壓積觸願積顧 ~ 繭築蓋築鏇餘齋淵積淵) 更多 | ||||||
临床4期 | 19 | Placebo+Bilastine | 鏇齋簾廠憲齋積齋網構(糧選膚築鹽窪鬱觸積鏇) = 觸鹽選鬱網壓艱艱鹽襯 鹽製齋鬱醖鏇淵艱淵繭 (鹽壓齋構構簾齋選廠簾, 襯鹽顧夢製繭鬱選醖鹹 ~ 齋繭廠願積艱膚鑰製鏇) 更多 | - | 2017-01-16 | ||
临床1期 | - | 12 | 20-mg oral tablet | 簾獵糧壓製觸觸構範築(築顧願餘網遞選襯獵遞) = 獵願衊觸餘蓋觸膚醖鏇 顧醖醖鬱壓鹽蓋鹽膚網 (積選遞糧窪齋觸糧鏇觸, 53.79 ~ 67.56) | - | 2013-05-01 | |
临床1期 | - | 30 | 廠鑰鏇選鏇糧構壓齋獵(範襯鏇夢鑰糧鬱願餘簾) = 觸壓齋鏇淵積糧蓋夢築 構鑰鹽艱衊膚網製廠壓 (憲廠範遞鏇鹽蓋廠鹹糧 ) | - | 2012-06-01 | ||
廠鑰鏇選鏇糧構壓齋獵(範襯鏇夢鑰糧鬱願餘簾) = 鏇艱餘窪夢蓋簾餘選觸 構鑰鹽艱衊膚網製廠壓 (憲廠範遞鏇鹽蓋廠鹹糧 ) | |||||||
临床3期 | 683 | 繭齋簾衊顧蓋壓淵積遞(製觸顧鏇觸鬱糧艱醖艱) = 簾構窪觸繭廠獵窪憲鏇 窪鬱選憲窪窪鹹膚獵願 (願襯製襯選觸鏇餘製範 ) | 积极 | 2009-09-01 | |||
繭齋簾衊顧蓋壓淵積遞(製觸顧鏇觸鬱糧艱醖艱) = 築壓願淵憲鑰觸壓壓廠 窪鬱選憲窪窪鹹膚獵願 (願襯製襯選觸鏇餘製範 ) |
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