预约演示
更新于：2026-07-24
Sodium Oxybate
羟丁酸钠
更新于：2026-07-24
概要
基本信息
最高研发阶段批准上市 |
首次获批日期 美国 (2002-07-17), |
最高研发阶段(中国)批准上市 |
特殊审评孤儿药 (美国)、孤儿药 (欧盟)、孤儿药 (澳大利亚) |
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结构/序列
分子式C4H8NaO3 |
InChIKeyWFBCFGRDCIMEAM-UHFFFAOYSA-N |
CAS号502-85-2 |
关联
65
项与 羟丁酸钠 相关的临床试验NCT07041203
Central Mechanisms and Treatment Response of Sodium Oxybate (Lumryz) in Spasmodic Dysphonia and Voice Tremor
Using a comprehensive approach of clinico-behavioral testing and neuroimaging, the researchers will examine the clinical effects of the extended-release formulation of sodium oxybate on voice symptoms in spasmodic dysphonia in an open-label, proof-of-concept, dose-finding study.
开始日期2026-10-01 |
NCT07596342
Electrophysiological Analysis of Gamma-Hydroxybutyrate-induced Sleep in Intensive Care Patients: A Pilot Double-Blind Randomized Controlled Trial
In intensive care, sleep disturbances are extremely common and represent a major source of discomfort for patients. Restorative sleep is very limited. Beyond being the primary source of discomfort reported by patients, these sleep disturbances are associated with difficulties in weaning from mechanical ventilation, an increased risk of delirium, and potentially higher mortality. Traditional treatments artificially increase the total duration of sleep but lead to disrupted sleep architecture.
Gamma-hydroxybutyrate (GHB) is currently used for several sleep disorders, such as narcolepsy, due to its ability to increase restorative sleep. This medication has been used for years as a sedative in intensive care. Despite these potential benefits, the efficacy of GHB has never been evaluated for sleep disturbances in intensive care settings.
This study focuses on evaluating the effectiveness of intravenous Gamma-hydroxybutyrate (GHB) in the treatment of sleep disorders in intensive care.
Gamma-hydroxybutyrate (GHB) is currently used for several sleep disorders, such as narcolepsy, due to its ability to increase restorative sleep. This medication has been used for years as a sedative in intensive care. Despite these potential benefits, the efficacy of GHB has never been evaluated for sleep disturbances in intensive care settings.
This study focuses on evaluating the effectiveness of intravenous Gamma-hydroxybutyrate (GHB) in the treatment of sleep disorders in intensive care.
开始日期2026-06-01 |
NCT06950281
Low Sodium Oxybate Use for Nocturnal Cluster Headache: Safety, Efficacy and Tolerability of JZP-258 (XYWAV) - a Phase 2 Randomized, Double-Blind, Placebo-Controlled, Bi-center Study.
The goal of this clinical trial is to evaluate the efficacy of low sodium oxybate (LXB) (brand name Xywav) in the treatment of (nocturnal) cluster headache attacks in subjects with chronic cluster headache.
It is an 16 week, randomized, double-blind, placebo- controlled, bi-center trial.
LXB will be administered as a twice nightly regimen. All subjects will undergo an 6 week Treatment Titration and Optimization Phase.
The main trial endpoint is the change from baseline in average weekly frequency of nocturnal cluster headache attacks over 4-week fixed stable dose of treatment period.
It is an 16 week, randomized, double-blind, placebo- controlled, bi-center trial.
LXB will be administered as a twice nightly regimen. All subjects will undergo an 6 week Treatment Titration and Optimization Phase.
The main trial endpoint is the change from baseline in average weekly frequency of nocturnal cluster headache attacks over 4-week fixed stable dose of treatment period.
开始日期2026-01-01 |
100 项与 羟丁酸钠 相关的临床结果
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100 项与 羟丁酸钠 相关的转化医学
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100 项与 羟丁酸钠 相关的专利（医药）
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4,155
项与 羟丁酸钠 相关的文献（医药）2026-08-01·INTERNATIONAL JOURNAL OF DRUG POLICY
Novel benzodiazepines in illicit drug use: sentinel emergency department data do not indicate disproportionate clinical harm
Article
作者: Weber, Courtney ; Lyons, Tom ; Hodgson, Sarah ; Schumann, Jennifer ; Greene, Shaun
BACKGROUND:
Novel or unregulated benzodiazepines are increasingly detected in illicit drug markets and may be perceived to pose greater clinical risk than regulated pharmaceutical benzodiazepines. However, much of the evidence underpinning these concerns derives from case reports, surveillance data, and settings characterised by extensive polysubstance exposure. We examined whether detection of novel/unregulated benzodiazepines is associated with greater acute clinical severity than pharmaceutical benzodiazepines in emergency department cases.
METHODS:
We conducted a retrospective analysis of the Emerging Drugs Network of Australia- Victoria (EDNAV) clinical registry, including analytically confirmed benzodiazepine-positive cases between 1 September 2020 and 30 November 2025. Cases were classified as involving novel/unregulated benzodiazepines (with or without pharmaceutical benzodiazepines) or pharmaceutical benzodiazepines only. Primary outcomes included severe toxicity (any of - intensive care unit admission, intubation, vasopressor use), respiratory depression, Poisoning Severity Score (PSS ≥3), and in-hospital mortality. Multivariable logistic regression was used to estimate adjusted odds ratios (aORs), accounting for age, sex, and co-detection of opioids, stimulants, and gamma-hydroxybutyrate (GHB).
RESULTS:
Among 2,638 benzodiazepine-positive cases, 772 cases involved detection of at least one novel/unregulated benzodiazepine (with or without concurrent pharmaceutical benzodiazepines) and 1,866 involved pharmaceutical benzodiazepines without any novel/unregulated benzodiazepines detected. Unadjusted analyses showed lower rates of several severe outcomes in the novel/unregulated group. After adjustment, detection of novel/unregulated benzodiazepines was not associated with increased odds of severe toxicity (aOR 0.84, 95% CI 0.67-1.06) or PSS ≥3 (aOR 1.00, 95% CI 0.83-1.21). Opioid and GHB co-detection were the strongest predictors of severe outcomes.
CONCLUSIONS:
In this analytically confirmed cohort, novel/unregulated benzodiazepines were not associated with greater acute clinical severity than pharmaceutical benzodiazepines once polysubstance exposure was accounted for. These findings suggest that observed acute benzodiazepine-related harms are driven primarily by patterns of co-use, particularly opioid co-exposure, rather than regulatory status of benzodiazepine compounds.
2026-07-01·BIOSENSORS & BIOELECTRONICS
Smartphone-assisted lateral flow nanosensor for the selective detection of GHB in urine
Article
作者: Montà-González, Giovanni ; Climent, Estela ; Martínez-Máñez, Ramón ; Hernández-Montoto, Andy ; Ortiz-Gómez, Eduardo ; Garrido, Eva ; López-Lima, Rocío ; Hernández-Sigüenza, Guillermo ; Gaviña, Pablo ; Martí-Centelles, Vicente ; Mollá-Guerola, Lara
We report a rapid test strip based on mesoporous silica nanoparticles functionalized with a specific GABAB receptor agonist to selectively detect γ-hydroxybutyric acid (GHB) in urine samples. The sensing mechanism involves rhodamine B-loaded MCM-41 silica nanoparticles whose pores are capped with a GABA-derived ligand (baclofen) acting as a gatekeeper via supramolecular interactions with the GABAB receptor protein. In the presence of GHB, competitive binding produces GABAB receptor protein displacement, leading to pore opening and fluorophore release, which is detected via fluorescence readout. The nanosensor demonstrated high sensitivity, with a limit of detection (LOD) of 168 μM in buffer solution and 41 μM in diluted urine. Selectivity assays showed highly specific sensor response over common drugs such as cocaine, morphine, MDMA, heroin, scopolamine, 1,4-butenediol (1,4-BD), γ-aminobutyric acid (GABA), and γ-butyrolactone (GBL). The sensing material was also incorporated into a lateral flow assay (LFA) platform with a smartphone-assisted fluorescence readout, providing a rapid, portable, and low-cost analysis of GHB. The resulting test strip exhibited high sensitivity, with a LOD of 0.28 μM in diluted urine, which is low enough to clearly distinguish between physiological endogenous GHB levels (∼96 μM) and exogenous intake within only 1 min, a crucial requirement in forensic and clinical toxicology. This portable, cost-effective method holds strong potential for on-site forensic and clinical GHB screening.
2026-06-01·Addictive behaviors reports
Addictive disorders and correlates in the context of chemsex practices: A French online survey
Article
作者: Daveluy, Amélie ; Desnavailles, Pauline ; Pavirani, Luca ; Jakubiec, Louise ; Cazanave, Charles ; Fatseas, Melina
Background:
Existing evidence shows that chemsex practice can contribute to adverse health outcomes. However, the presence of addictive disorders based on DSM-5 criteria remains underexplored in this population. The present study aimed to assess the overall prevalence and associated factors of substance use disorders (SUDs) and chemsex addiction among individuals engaged in chemsex, using an online self-report questionnaire.
Methods:
The sample included 132 French adults having engaged in chemsex within the previous 12 months. Sociodemographic characteristics, substance use patterns, DSM-5 criteria for substance use disorders and DSM-5 criteria adapted to assess chemsex addiction, associated consequences, and sexual practices were collected. Univariate analyses and logistic regression models were conducted to explore factors associated with substance and chemsex-related addictions.
Results:
The most frequently used substances were synthetic cathinones, followed by GHB/GBL and stimulants. Addictive disorders were highly prevalent, particularly cathinone use disorder and addiction to chemsex practice, which were associated with increased negative consequences, notably mental health problems and suicidal ideation. The presence of cathinone use disorder was associated with GHB/GBL use disorder, loss of control over sexual behavior, craving for sex, and chemsex addiction. Both cathinone use disorder and craving for sex significantly predicted chemsex addiction.
Discussion:
This study highlights the importance of assessing addictive disorders in the context of chemsex by integrating both substance and behavioral addictions, given the strong interconnection between substance use and sexuality. Multidimensional and integrated treatment approaches are needed to adequately prevent and manage specific addictive patterns and associated risk-taking behaviors among individuals engaged in chemsex.
331
项与 羟丁酸钠 相关的新闻（医药）2026-07-23
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一款针对罕见病的新机制创新药，在全球同步研发、同步申报，中国第一个批了。这背后不只是一个药的故事，更是中国新药审评从"跟跑"到"领跑"的一次标志性跃迁。
7 月 21 日，国家药监局批准了一款全球首个选择性食欲素 2 型受体激动剂上市，专门用于治疗 16 岁及以上青少年和成人的 1 型发作性睡病。更关键的是，这款药在中国、美国、日本、欧盟同步申报，最终由中国率先批准。这是全球多中心研发的原创靶点创新药首次在中国实现"首报首发"。
过去我们总是"等欧美批完再用"，这一次，中国患者成了地球上最早能用上的人。
这个病到底多折磨人？
开着车突然睡着，吃着饭突然睡着，开会时一头栽到桌上……这不是段子，是 1 型发作性睡病患者每一天都要对抗的现实。
发作性睡病是一种慢性神经系统罕见病，主要分 1 型和 2 型。患者最核心的症状不是"爱睡觉"，而是大脑失去了对清醒的控制：
白天过度嗜睡：走路、吃饭、说话、开会时随时可能突然睡着，每天反复发作
猝倒发作：大笑、兴奋等强烈情绪一来，肌肉突然瘫软，可能当场跪倒或垂下头
睡眠瘫痪：俗称"鬼压床"，意识清醒却全身动不了
入睡幻觉：半梦半醒之间看到、听到并不存在的东西
近一半的患者有过开车时睡着的经历，事故风险显著升高。这是一种终身性疾病，过去只能靠中枢兴奋剂"硬扛"症状，并没有一款药能真正补上大脑里缺失的那个信号。
这次的新药，到底"新"在哪？
要理解它的革命性，得先弄明白一个关键词：食欲素。
食欲素是大脑下丘脑分泌的一种神经肽，相当于人体"保持清醒的总开关"。它通过与两种受体（OX1R 和 OX2R）结合，持续向大脑发送"别睡了、撑住"的信号。
1 型发作性睡病患者的问题出在哪？
他们下丘脑中产生食欲素的神经元被自身免疫系统攻击、大量失能，导致大脑里几乎不再分泌食欲素。开关坏了，人就随时"断电"。
过去的药（莫达非尼、哌甲酯、羟丁酸钠等）做的是同一件事：绕开开关，强行用电筒照明。困了就用兴奋剂刺激神经，猝倒了就用抗抑郁药压住异常睡眠信号。它们有效，但没有一种药去修那个坏掉的开关。
这次的新药换了个思路
它是一款"选择性食欲素 2 型受体（OX2R）激动剂"，相当于一把特制的备用钥匙。就算大脑造钥匙的工厂（神经元）停工了，这把药做的钥匙也能直接插进锁孔，把清醒通路重新打开。
也就是说，它从"对抗症状"走向了"针对病因"。这也是为什么它被定义为"新靶点、新机制"的全球首创药。
为什么是"中国首发"？
这款药在中国、美国、日本、欧盟同时申报，四个市场都在赛跑，最后是中国先撞线。
凭什么？
因为它在中国拿到了"双重加速通道"。既获得"突破性治疗品种认定"，又被纳入"优先审评审批程序"；在美国走的是突破性治疗药物 + 快速通道；在日本是先驱药 + 孤儿药资格；在欧盟是孤儿药资格。
中国的加速通道到底有多快？
根据国家药监局公开数据，纳入优先审评审批程序的药品，审评时限可以从常规的 200 个工作日压缩到 130 个工作日；临床急需的境外上市罕见病用药，甚至可以进一步压缩到 70 个工作日。
这次的奥博雷通片，2024 年 9 月被纳入突破性疗法，2026 年 1 月 20 日纳入优先审评，7 月 21 日正式获批，从优先审评到上市只用了半年。
中国临床试验数据这次被 FDA 等国际监管机构认可用于注册。这意味着中国临床研究的质量已经达到了国际一流水平，未来跨国药企把中国纳入全球同步开发的计划会成为常态。
"中国首发"意味着什么？
对患者来说
过去那种"欧美先上、国内等三五年甚至更久"的苦日子正在结束。随着中国药品审评体系与国际接轨，越来越多跨国药企选择把中国纳入全球同步开发，中国患者有望第一时间获得全球最新的治疗方案。
对产业来说
跨国药企的研发和注册策略正在被改写。过去的路径是"境外先行上市→产品引进中国"；现在正在变成"全球研发一盘棋、中国同步设计、同步申报、同步商业化"。
对监管来说
这标志着我国在"全球新"药物研发领域，从靶点原创、同步推进国际多中心临床，再到注册上市，实现了全流程首报首发的历史性突破。
获批是第一步，但从"获批"到"患者真正用得上、用得起"，还有几道关要过：
定价与医保准入：这款药目前的定价、是否纳入医保、何时纳入，都还没有官方结论
医院铺货：即便上市，也需要一定时间才能在全国各级医院落地
适用人群有限：目前只获批用于 16 岁及以上的 1 型发作性睡病患者，2 型及儿童患者仍需等待后续研究
不是万能药：它是第一个验证"食欲素通路"这条路线的药，意味着这条路走通了，但每个患者的具体情况不同，依然需要医生评估
如果你或家人是发作性睡病患者，建议先到正规医院神经内科或睡眠专科就诊评估，不要自行购药尝试。
从"等药吃"到"同步用"，再到"全球先用"，这枚落在 7 月 21 日的公章，改写的远不止一款药的命运。
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2026-07-23
BMC Medicine [Jour] AND 24[volume] AND 1[issue]（first half of the year）
生物医学中心 - 医学 24卷 1期（上半年）
https://link.springer.com/journal/12916/volumes-and-issues/24-1
369 articles in this issue
Impact of a real-time automatic quality control system for magnetically controlled capsule gastroscopy: a multicenter randomized controlled trial
磁控胶囊胃镜实时自动质量控制系统的效果：一项多中心随机对照试验
Xiaoya WangDawei ShenZhen Li
Research 02 May 2026
Article: 369
Lipid levels and risk-stratified management gaps of dyslipidemia in China
中国血脂水平及血脂异常风险分层管理差距
Long ZhangXu LiuJianping Li
Research 02 May 2026
Article: 368
Medicine price and affordability in China and selected ASEAN countries: a cross-country comparison with forward-looking implications for regional pooled procurement
中国与部分东盟国家的药品价格和可负担性：对区域集中采购前瞻性影响的跨国比较
Zhuangqi LiShuting ZhangBao Liu
Research 02 May 2026
Article: 367
Dementia risk by metabolic health and obesity in two prospective cohorts
两项前瞻性队列研究中代谢健康和肥胖对痴呆风险的影响
Martin NakashElsa Ojalehto LindforsIda K. Karlsson
Research 19 June 2026
Article: 366
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Maternal B-vitamin status modifies the risk of congenital heart disease in offspring associated with prenatal persistent organic pollutants exposure
母体B族维生素状况会改变胎儿在宫内持续暴露于有机污染物时先天性心脏病的患病风险
Sainan LiHai LinLinlin Wang
Research 04 May 2026
Article: 365
Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications
肥胖衍生的代谢产物在肿瘤微环境中调节抗肿瘤免疫：从机制到临床应用
Yihang CaiJunyi JinXiaoying Li
Review 06 May 2026
Article: 364
Part of 1 collection:Tumor microenvironment in cancer therapy
所属专题合集：癌症治疗中的肿瘤微环境
Rational use of expensive medicines in the Netherlands: strategies to improve effectiveness and reduce burden on patients and society – a narrative review
荷兰高价药品的合理使用：提高疗效、减轻患者和社会负担的策略——一项叙述性综述
Bart M.F. PenninxSander W. TasCarla E.M. Hollak
Review 30 April 2026
Article: 363
NMR-based serum metabolite and lipoprotein profiling for endometriosis across clinically relevant and physiological comparator settings: assessment of diagnostic utility and exploratory biological signals
基于核磁共振（NMR）的血清代谢物和脂蛋白谱分析在子宫内膜异位症的临床相关和生理对照情况中的应用：诊断效用的评估和探索性生物信号的发现
Sisi DengAndré KochChristoph Trautwein
Research 17 June 2026
Article: 362
Changes in olfactory function in children and adolescents with obesity following an inpatient weight loss program: a longitudinal study
住院减肥计划后肥胖儿童和青少年嗅觉功能的变化：一项纵向研究
Bea KlosHelene SauerIsabelle Mack
Research 17 June 2026
Article: 361
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预及其对健康的影响
The neuroimmune axis in breast cancer: from mechanistic insights to clinical applications
乳腺癌中的神经免疫轴：从机制研究到临床应用
Yimao WuKaiyu ZhangMeng-Yao Li
Review 30 April 2026
Article: 360
A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics
基于化学感觉遗传学的饮食孟德尔随机化工具选择生物学框架
Liang-Dar HwangCailu LinPaule V. Joseph
Research 01 June 2026
Article: 359
Efficacy and safety of cyclosporine plus luspatercept versus cyclosporine in newly diagnosed non-transfusion-dependent non-severe aplastic anemia: A prospective randomized trial
环孢素联合卢帕塞普特与单用环孢素治疗新发非输血依赖型非重型再生障碍性贫血的疗效和安全性：一项前瞻性随机试验
Zhuxin ZhangQinglin HuBing Han
Research 29 April 2026
Article: 358
Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study
非洲人群的膳食摄入与表观遗传衰老：RODAM研究中的食物组、膳食模式与植物性饮食
Naomi C.S. AuwerdaMuhau. M. MungambaFelix P. Chilunga
Research 28 April 2026
Article: 357
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Mitoxantrone hydrochloride liposome (Lipo-MIT) combined with capecitabine in HER2-negative advanced breast cancer: a dose-escalation, phase I study
米托蒽醌盐酸盐脂质体（Lipo-MIT）联合卡培他滨治疗HER2阴性晚期乳腺癌：一项剂量递增Ⅰ期研究
Jiaxuan LiuMingxia JiangQiao Li
Research 28 April 2026
Article: 356
Familial healthy aging and longevity: the role of spouses
家族健康衰老与长寿：配偶的作用
Søren NetraAngéline GalvinKaare Christensen
Research 28 April 2026
Article: 355
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer’s disease
外周血生物标志物RCAN1、Clusterin、RAGE和丙二醛用于阿尔茨海默病的早期诊断与进展监测
Aurora Román-DomínguezCristina Mas-BarguesJosé Viña
Research 27 April 2026
Article: 354
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Palliative care for the people without medical insurance in Germany: an empirical ethical approach
德国无医疗保险人群的姑息治疗：一种实证伦理方法
Matthias ZimmerAntonia Sahm
Research 11 June 2026
Article: 353
Part of 1 collection:Palliative care and medicine
所属专题合集：姑息治疗与姑息医学
Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study
妊娠期母体因素与微生物衍生的细胞外囊泡特征的相关性：一项临床队列研究
Jenni TurunenKaisu KyröTerhi Ruuska-Loewald
Research 28 May 2026
Article: 352
Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother–child paired cohort study
产前计算机断层扫描（CT）与先天性心脏病及脑瘫风险：一项全国性母子配对队列研究
Tae Wook KangJihye HeoDanbee Kang
Research 27 April 2026
Article: 351
Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease
治疗性TG2抑制可逆转乳糜泻的系统性多组学失调
Valeriia DotsenkoHana Hien Leon behalf of the CEC-3 Investigators
Research 24 April 2026
Article: 350
Adulthood stressful life events as predictors of incident cardiovascular disease: insights from two prospective cohorts
成年期应激性生活事件作为心血管疾病新发预测因子：来自两项前瞻性队列的见解
Shuang WuSiqi LyuGregory Y. H. Lip
Research 24 April 2026
Article: 349
Camrelizumab plus apatinib for immune checkpoint inhibitor-naive patients with metastatic clear cell renal cell carcinoma after first-line tyrosine kinase inhibitor treatment failure: a single-arm phase 2 trial
卡瑞利珠单抗联合阿帕替尼用于免疫检查点抑制剂初治转移性透明细胞肾细胞癌一线酪氨酸激酶抑制剂治疗失败后：一项单臂Ⅱ期试验
Xiuyu CaiXia ZhengPei Dong
Research 24 April 2026
Article: 348
Introducing the need for a consensus-based framework for protocol modifications to improve trial trustworthiness
提出建立基于共识的方案修改框架以提升临床试验可信度的必要性
Cora BurgwinkelManon GicquelClara Locher
Debate 24 April 2026
Article: 347
Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies
中国女性人群HPV流行动力学建模及宫颈癌消除策略优化
Yuwei LiYi-Fan LinJianxin Zhen
Research 22 April 2026
Article: 346
Multiparameter concept-based interpretable model for early breast cancer diagnosis and structured reporting: a multi-center, multi-reader, radiologist-in-the-loop study
基于多参数概念的可解释模型用于早期乳腺癌诊断与结构化报告：一项多中心、多读者、放射科医师参与的研究
Jiao QuYang LiuSu Lui
Research 23 April 2026
Article: 345
Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction
基于血液DNA甲基化标志物模型的肺癌短期与长期风险预测
Megha BhardwajYi-Qian SunHermann Brenner
Research 06 June 2026
Article: 344
Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study
整合血清蛋白质组学与肝脏基因组学分析鉴定与代谢功能障碍相关脂肪性肝病相关的分子特征：一项多队列研究
Jinjian XuWanglong GouYu-ming Chen
Research 17 April 2026
Article: 343
Predicting amyotrophic lateral sclerosis stage based on multi-parameter ultrasound: development and validation of an interpretable machine learning model
基于多参数超声预测肌萎缩侧索硬化症分期：可解释机器学习模型的构建与验证
Tianhua YangYing WangGaoyi Yang
Research 22 April 2026
Article: 342
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与更新
Duration of anti-seizure medicines started for acute symptomatic seizures due to acute meningitis: a systematic review and meta-analysis
急性脑膜炎所致急性症状性发作的抗癫痫药物起始疗程：一项系统综述与荟萃分析
Manya PrasadAmit KumarTarun Dua
Research 22 April 2026
Article: 341
Part of 1 collection:Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述集
Prenatal exposure to flood and risk of low birth weight: a multi-country study from 36 African countries
产前遭遇洪水与低出生体重风险：来自36个非洲国家的多国研究
Qian LiQian LiFengchao Liang
Research 21 April 2026
Article: 340
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Sunshine duration and episodes of mental disorders and the inverse effect modification by ambient temperature
日照时长与精神障碍发作及环境温度的逆效应修饰
Lijun BaiJuan ChenShaowei Wu
Research 21 April 2026
Article: 339
The role of continuous glucose monitoring for diagnosis of gestational diabetes: exploring the potential
持续葡萄糖监测在妊娠糖尿病诊断中的作用：潜力探索
M. CrowleyC. NewmanF. P. Dunne
Review 21 April 2026
Article: 338
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠糖尿病的诊断与治疗
Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records
应激相关障碍诊断前生物标志物与风险：一项基于电子健康记录的队列
Anna A. PeltolaEsha KhanJake Lin
Research 01 June 2026
Article: 337
Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters
气候相关灾害后DNA甲基化信号的全表观基因组分析
Wenzhong HuangRongbin XuYuming Guo
Research 20 April 2026
Article: 336
Part of 1 collection:Climate change and human health
所属专题合集：其后变化与人类健康
Redeemed prescription medicines to measure quality of life of patients with long-term conditions: a national cross-sectional study
通过已兑换的处方药衡量慢性病患者生活质量：一项全国性横断面研究
Henrik Hedegaard Pliess LarsenVolkert SiersmaAnne Holm
Research 20 April 2026
Article: 335
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
属于专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Viral shedding dynamics in coxsackievirus A6 hand, foot, and mouth disease: a prospective, individual-level analysis
柯萨奇病毒A6型手足口病的病毒排毒动态：一项前瞻性个体水平分析
Jiale MengYue ChengLu Long
Research 18 April 2026
Article: 334
Mental health and wellbeing interventions for uniformed service personnel: a mixed methods systematic review
军警人员心理健康与福祉干预措施：一项混合方法系统综述
Jessica EatonHolly EllardAlan Simpson
Research 17 April 2026
Article: 333
WISE-Therapy (What’s Important: Schedule and Engage) and bouldering psychotherapy for depression: A randomized clinical trial
WISE-Therapy（智慧疗法）（重要之事：安排与参与）与抱石心理治疗用于抑郁症：一项随机临床试验
Johannes KornhuberPiotr LewczukKatharina Luttenberger
Research 27 May 2026
Article: 332
Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention
握力减弱与类风湿关节炎患者运动皮层萎缩相关：一项包含手部运动干预的横断面研究
Amanda L GustafssonRolf A HeckemannCaroline Wasén
Research 26 May 2026
Article: 331
Interpretable multimodal PET/CT-EHR fusion via mixture-of-experts for prognostic stratification in mantle cell lymphoma: a multicenter study
基于专家混合模型的可解释性多模态PET/CT-HER（电子健康记录）融合在套细胞淋巴瘤预后分层中的应用：一项多中心研究
Chong JiangZitong ZhangRong Tian
Research 16 April 2026
Article: 330
Non-invasive diagnosis strategy integrating PSMA PET/CT and mpMRI for patients with suspected prostate cancer: a multi-center study
整合PSMA PET/CT与多参数MRI的无创诊断策略用于疑似前列腺癌患者：一项多中心研究
Yuhang WangYongxiang TangYi Cai
Research 16 April 2026
Article: 329
Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial
晚期窗口缺血性卒中中即使再通失败，替奈普酶仍具临床获益：TRACE-3试验的事后分析
Zhengzhao LuZiran WangYongjun Wang
Research 16 April 2026
Article: 328
Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study
婴儿皮层下脑容量与母亲肥胖及糖尿病相关：一项大型多队列人类研究
Ann M. AlexJerod M. RasmussenENIGMA-ORIGINs working group
Research 16 April 2026
Article: 327
Cost-effectiveness of prehabilitation for elderly (pre-)frail patients prior to elective surgery compared to standard care - an economic evaluation from a societal perspective
择期手术前老年（衰弱前期/）衰弱患者预康复与标准护理的成本效益比较——一项基于社会视角的经济学评估
Tanja RombeyHelene EckhardtLukas Schöner
Research 21 May 2026
Article: 326
Frozen melanoma tissues yield extracellular vesicles with preserved diagnostic and immunogenic properties
冷冻黑色素瘤组织可获得具有保存完好的诊断和免疫特性的细胞外囊泡
Daniele D´ArrigoKyong-Su ParkRossella Crescitelli
Research 21 May 2026
Article: 325
Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children
儿童mRNA疫苗接种所引发的分层防御免疫动力学的潜在机制
Yiyu LiaoHoong Kai ChuaKeisuke Ejima
Research 15 April 2026
Article: 324
Epigenetic aging markers in the association between frailty and mortality among U.S. adults
美国成年人虚弱与死亡率相关性中的表观遗传衰老标志物
May A. BeydounNicole Noren HootenAlan B. Zonderman
Research 15 April 2026
Article: 323
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Evolution with age of the relationship between sex and post-COVID symptoms: a population-based cohort study
性别与新冠后遗症症状关系随年龄的演变：一项基于人群的队列研究
Anne PastorelloCécile Vuillermozfor the EpiCov study group
Research 14 April 2026
Article: 322
Bowel cancer care in individuals with an intellectual disability: a population-based cohort study of symptoms, diagnostic pathways, treatment and survival
智力障碍个体的肠癌护理：症状、诊断路径、治疗及生存的基于人群的队列研究
Oliver John KennedyUmesh ChauhanDarren Mark Ashcroft
Research 20 May 2026
Article: 321
Association of antiviral use for influenza among non-severe cases with subsequent hospitalization and mortality
非重症流感病例使用抗病毒药物与后续住院及死亡的关系
Taito KitanoShinya TsuzukiSayaka Yoshida
Research 06 April 2026
Article: 320
Social and digital engagement associated with reduced depressive symptoms in adults aged 50 and older: a multi-country cohort study
社交及数字互动与50岁及以上成年人抑郁症状减少的关系：一项多国队列研究
Yaping WangLiyuan TaoJue Liu
Research 07 April 2026
Article: 319
Fat-soluble vitamin deficiency in children with neurodevelopmental disorders: a cross-sectional study
神经发育障碍儿童脂溶性维生素缺乏：一项横断面研究
Jingjing RaoXiaomei WangChangzhen Li
Research 08 April 2026
Article: 318
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA)
巴尔的摩老龄化纵向研究（BLSA）中骨骼肌与心肌的纵向关联
Jie Jun WongFei GaoAngela S. Koh
Research 06 April 2026
Article: 317
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用
Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study
早期重复经颅磁刺激预防老年患者慢性术后疼痛：一项随机临床子研究
Wei-Wei ZhouZhi YangChao-Chao Zhong
Research 06 April 2026
Article: 316
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能障碍中的神经调控
Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus
合并糖尿病的肺结核治疗失败结局的临床流行病学与风险预测
Ping LiFeilong LuJunjun Jiang
Research 25 March 2026
Article: 315
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Spatiotemporal patterns of climate-sensitive vector-borne diseases in Bangladesh: leveraging machine learning and spatial regression for intervention strategies
孟加拉国气候敏感型虫媒传染病的时空格局：利用机器学习与空间回归制定干预策略
Md. Siddikur RahmanMd. Abu Bokkor ShiddikArman Hossain Chowdhury
Research 13 April 2026
Article: 314
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
The association of pregnancy complications/risk factors with the development of cancer in women: an umbrella review
妊娠并发症/危险因素与女性癌症发生的关系：一项伞状综述
Jemma HealeyMegha SinghMairead Black
Research 13 April 2026
Article: 313
Synergistic effects of obesity and type 2 diabetes on adiposity-related cancer risk across age strata
肥胖与2型糖尿病对不同年龄层肥胖相关癌症风险的协同效应
Alex E. HenneyMegan HeagueDaniel J. Cuthbertson
Research 13 April 2026
Article: 312
Acute COVID-19 severity and impaired cognitive function up to 32months after diagnosis: an observational study
急性新冠严重程度与确诊后长达32个月的认知功能损害：一项观察性研究
Ingibjörg MagnúsdóttirAnders B. NygaardUnnur Anna Valdimarsdóttir
Research 11 April 2026
Article: 311
Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses
孕产妇宏量营养素摄入与妊娠期糖尿病：前瞻性观察研究的系统综述及剂量反应荟萃分析
Cameron D. YoungMichael G. GarrattAndrew N. Reynolds
Research 11 April 2026
Article: 310
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与管理
Global, regional, and national burden of colorectal cancer attributable to central obesity: a population attributable fraction analysis
中心性肥胖所致结直肠癌的全球、区域及国家负担：人群归因分数分析
Daniele PiovaniGisella FiglioliStefanos Bonovas
Research 10 April 2026
Article: 309
Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study
评估首段尿液中DNA甲基化标志物及扩展型HPV基因分型在HPV阳性女性中检测高级别宫颈病变的价值：一项横断面研究
Mette TranbergSeverien Van KeerRenske Steenbergen
Research 10 April 2026
Article: 308
Targeted long-read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness
靶向长读长基因组与表观基因组测序提升低张力与肌无力的全面变异及时发现
Eman AbuijlanShruti SinhaAhmad Abou Tayoun
Research 08 April 2026
Article: 307
Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions
靶向肺疾病中的免疫衰老：机制洞察与临床干预
Yin ZhangXianzhe YuFengming Luo
Review 08 April 2026
Article: 306
Apolipoprotein C3 drives adverse cardiac remodeling in ischemic heart failure
载脂蛋白C3促进缺血性心力衰竭中的不良心脏重塑
Yufei HanYixue ZhaoXunde Xian
Research 09 April 2026
Article: 305
Part of 1 collection:Cardiac immunity and inflammation
所属专题合集：心脏免疫与炎症
Causal modeling of school aversion in psychiatrically referred adolescents: a DoWhy-based analysis
转诊精神病科的青少年厌学情绪的因果模型：基于DoWhy的分析
Mengmeng ZhangXin MaMeijuan Wang
Research 09 April 2026
Article: 304
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Aperiodic and periodic neural activity during sleep in autism spectrum disorders
自闭症谱系障碍睡眠中的非周期性和周期性神经活动
Noemi MazzoniEva-Maria KurzAndrea Caria
Research 18 March 2026
Article: 303
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Association and mediating pathways between intergenerational educational mobility and depressive symptoms: findings from high- and middle-income countries
代际教育流动性与抑郁症状之间的关联及中介路径：来自高收入和中等收入国家的发现
Yingchao ZengSimu HuangChihua Li
Research 02 April 2026
Article: 302
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Scoping review on the prioritisation of high-consequence infectious pathogens for research preparedness and response to health emergencies
关于优先研究高后果性感染病原体以应对突发卫生事件的研究准备与响应的范围综述
Nicolas PulikHolly SadlerAlice Norton
Research 01 April 2026
Article: 301
Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia
中国儿童和青少年血清尿酸水平：高尿酸血症的百分位参考值和全国患病率估计
Qianrang ZhuXin’nan ZongMin Zhao
Research 31 March 2026
Article: 300
Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank
腰围和握力及其与英国生物银行中2型糖尿病发病风险的联合关系
Johanna WirlerMichael J. SteinMichael F. Leitzmann
Research 07 May 2026
Article: 299
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia–reperfusion
靶向心肌细胞衍生的外泌体miR-574-5p可预防缺血再灌注引起的认知障碍
Erya ChenXiaoyu ZhuChan Chen
Research 19 March 2026
Article: 298
Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation
皮层下卒中后左侧额下回的运动相关重组：神经化学基础及靶向神经调控的反应
Wenjun HongYaxi WangZhiyong Zhao
Research 27 March 2026
Article: 297
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能疾病中的神经调控
Association between ambient temperature and childhood vaccination coverage in low- and middle-income countries
中低收入国家环境温度与儿童疫苗接种覆盖率之间的关联
Hongqiu ZhengYixiang ZhuZhiyuan Hou
Research 11 March 2026
Article: 296
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss
肌萎缩侧索硬化症奖赏回路白质改变：基于纤维束的食欲减退研究
Jeryn ChangHarry LipscombeThomas B. Shaw
Research 27 March 2026
Article: 295
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis
替西帕肽在心血管事件风险增加患者中的不良反应：一项系统综述与荟萃分析及试验序贯分析
Christina Dam Bjerregaard SillassenPascal FaltermeierJanus Christian Jakobsen
Research 27 March 2026
Article: 294
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预措施及其健康影响
Age-related genomic characterization and therapeutic targets in Chinese breast cancer: insights from prospective targeted sequencing and clinical data analysis
中国乳腺癌年龄相关基因组特征及治疗靶点：前瞻性靶向测序与临床数据分析的见解
Xin-Yi SuiXiao-Qing SongLei Fan
Research 27 March 2026
Article: 293
Impact of the family cohesion-centered frailty intervention on older gastric cancer patients: a non-randomized controlled trial
以家庭凝聚力为中心的衰弱干预对老年胃癌患者的影响：一项非随机对照试验
Yinning GuoYimeng ChenQin Xu
Research 27 March 2026
Article: 292
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症临床试验
Perceptions of HPV vaccination: a qualitative study with adolescents, parents, school staff, and pharmacists
对HPV疫苗接种的看法：一项针对青少年、家长、学校工作人员和药剂师的定性研究
Laurène HoutinLucia RomoClémence Brun
Research 26 March 2026
Article: 291
Risk classification of internet gaming disorder based on neurobiological subtyping from impulsivity-linked resting-state functional connectivity: a longitudinal design study
基于冲动性相关静息态功能连接神经生物学亚型的网络游戏障碍风险分类：一项纵向设计研究
Xinwen WenJiahao ZhaoKai Yuan
Research 26 March 2026
Article: 290
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Trainee-delivered school-based intervention with guided narrative writing for adolescent anxiety and depression: a cluster randomized controlled trial
由受训者实施的、基于学校的、以引导性叙事写作为干预手段的青少年焦虑和抑郁干预：一项整群随机对照试验
Yixuan WangMuyang LiYinyin Zang
Research 26 March 2026
Article: 289
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Nourishing future generations: the critical role of healthy school lunches and strategic food procurement
滋养未来一代：健康学校午餐和战略性食品采购的关键作用
Aurora Perez-CornagoCarmen Piernas
Comment 05 May 2026
Article: 288
Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury
多组学分析揭示人类骨骼肌损伤后肌无力的性别特异性病因
Alexander R. KeebleAllison M. OwenChristopher S. Fry
Research 26 March 2026
Article: 287
Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study
使用红细胞前期疟疾疫苗R21/Matrix-M进行追赶接种或额外加强接种的公共卫生影响：一项建模研究
Kelly McCainHillary M. TopazianAzra C. Ghani
Research 25 March 2026
Article: 286
A digital-health multidomain lifestyle management framework and its associations with cardiometabolic health: a real-world observational study
数字健康多领域生活方式管理框架及其与心脏代谢健康的关联：一项现实观察性研究
Han XiaoKexin DingDafang Chen
Research 25 March 2026
Article: 285
Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial
双侧序贯加速θ波爆发刺激治疗难治性抑郁症：一项开放标签随机对照试验
Xingxing LiEnze TangDongsheng Zhou
Research 25 March 2026
Article: 284
Part of 1 collection:Neuromodulation in brain functional disorders
所属专题合集：脑功能疾病中的神经调控
Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders
SPG7和AFG3L2基因突变双基因遗传导致运动神经元和小脑疾病
Mehrdad A. EstiarEric YuZiv Gan-Or
Research 24 March 2026
Article: 283
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新颖动态
Social isolation and 59 common health conditions: insights from observational and genetics analyses
社交孤立与59种常见健康状况：观察性研究与遗传学分析的见解
Sizhi AiQiqi WuYannis Yan Liang
Research 23 March 2026
Article: 282
Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes
基于背外侧前额叶-膝下前扣带回皮层峰值功能连接性的抑郁亚组聚类分析揭示了不同的症状特征和经颅磁刺激（TMS）治疗结果
Gai KongSirui WangYingying Tang
Research 23 March 2026
Article: 281
Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours
人类遗传学有力证据支持成纤维细胞生长因子21（FGF21）对减少饮酒行为的因果效应
Héléne T. CronjéSile HuDipender Gill
Research 23 March 2026
Article: 280
Artificial intelligence-based prediction of fetal hypoxia: a multicenter model development and nationwide AI-human comparison
基于人工智能的胎儿缺氧预测：多中心模型开发及全国范围的人工智能与人类对比
Suiwen LinXiaodan DiBin Liu
Research 21 March 2026
Article: 279
Efficacy and long-term engagement of a WeChat-integrated modality versus a traditional quitline on smoking cessation in China: a randomised controlled trial
微信整合模式与传统戒烟热线在中国戒烟中的疗效及长期参与度：一项随机对照试验
Shuilian ChuDi ZhangLirong Liang
Research 21 March 2026
Article: 278
A culturally-safe primary care intervention for migrant/refugee women suffering domestic violence and abuse: HARMONY—a pragmatic cluster randomised controlled trial
针对遭受家庭暴力和虐待的移民/难民妇女的文化安全初级护理干预措施：HARMONY——一项实用性整群随机对照试验
Angela J. TaftFelicity YoungGene Feder
Research 21 March 2026
Article: 277
Development, integration, retention, and career progression of physician associates/assistants in UK NHS hospitals and clinical teams: a multiple-case qualitative study
英国国家医疗服务体系（NHS）医院及临床团队中医师助理/协理医师的发展、整合、留任及职业晋升：一项多案例定性研究
Yingxi ZhaoRhys SwainstonThe ROADMAP-PA collaborator group
Research 20 April 2026
Article: 276
Compound climate extreme events and associated health impacts: a scoping review
复合气候极端事件及其相关健康影响：一项范围性综述
Shifali MathewsCaitlin WalkerJaime Madrigano
Research 20 March 2026
Article: 275
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort
吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析
Yue ChenSrimanti DuttaRudolf Kaaks
Research 28 April 2026
Article: 274
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Cortical functional hierarchy disruption following subcortical stroke
皮质功能层级在皮层下卒中后的破坏
Ke WuGang LiuGaolang Gong
Research 19 March 2026
Article: 273
Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization
利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响
Elisabeth AitonNancy S. McBrideMaria Carolina Borges
Research 19 March 2026
Article: 272
Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy
杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响
André Maurício Passos LiberMirella BarboniCyrille Vaillend
Research 25 April 2026
Article: 271
Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model
体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型
Fabian StögbauerTobias WeiserBarbara Wollenberg
Research 25 April 2026
Article: 270
Part of 1 collection:Organoids: connecting molecular insights and clinical practice
所属专题合集：类器官：连接分子见解与临床实践
Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study
2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究
Han-Cheng YuJi-Juan ZhangYun-Fei Liao
Research 18 March 2026
Article: 269
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities
2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析
GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren
Research 18 March 2026
Article: 268
Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study
全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究
Yunfei LiuShan CaiSusan M. Sawyer
Research 18 March 2026
Article: 267
Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules
相对白细胞端粒长度与肺结节患者肺癌进展风险的关系
Yuanyuan WuDong SunFeifei Cheng
Research 18 March 2026
Article: 266
Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial
太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验
Xuefeng LiuTong TangJing Tao
Research 17 March 2026
Article: 265
DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic
胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解
Qiwen FuQi WangLu Ma
Research 17 March 2026
Article: 264
Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa
非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态
Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku
Research 17 March 2026
Article: 263
Part of 1 collection:Mpox: Epidemiology, prevention, and treatment
所属专题合集：猴痘：流行病学、预防和治疗
SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection
SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性
Shuai ZhaoXiumeng HuaJiangping Song
Research 16 March 2026
Article: 262
Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors
中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用
Hui YangQin LiuBo Xi
Research 16 March 2026
Article: 261
The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis
住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析
Peilin JiaHailong ZhangLongyu Wang
Research 16 March 2026
Article: 260
Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study
更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系
Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers
Correction 22 April 2026
Article: 259
Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis
基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析
Liqing LiXiaoyao MengTingshi Su
Research 14 March 2026
Article: 258
Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study
瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究
Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson
Research 18 April 2026
Article: 257
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE)
男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析
Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne
Research 12 March 2026
Article: 256
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与管理
Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma
血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物
Jing LiYu PeiYi Liu
Research 12 March 2026
Article: 255
The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact
年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究
Chenkai ZhaoYuhe ZhangHarish Nair
Research 11 March 2026
Article: 254
A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress
一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为
Marisol I. DothardMariaelena CaboniPhilip Strandwitz
Research 10 March 2026
Article: 253
Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing
童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关
Monica AasThole H HoppenJulian Mutz
Research 28 April 2026
Article: 252
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals
高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究
Ziyi ZhouQiaosen ChenFrederick K. Ho
Research 16 April 2026
Article: 251
Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study
人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究
Guiquan WangMinyue TangYimin Zhu
Research 10 March 2026
Article: 250
PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study
PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究
Wangji ZhouLin WangXinlun Tian
Research 10 March 2026
Article: 249
Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study
颅外动静脉畸形的检出率及突变谱：一项队列研究
Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators
Research 16 April 2026
Article: 248
Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China
抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究
Qiang WangDavid HodgsonWeibing Wang
Research 09 March 2026
Article: 247
Cell therapy strategies for organ regeneration
器官再生的细胞治疗策略
L. PapamichailL. J. W. van der LaanM. J. Hoogduijn
Review 25 February 2026
Article: 246
Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery
经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物
Abdul RashadHe XijingMuhammad Asif
Registered Report 09 March 2026
Article: 245
Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT)
新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT）
Maohui ChenYizhou HuangBin Zheng
Research 09 March 2026
Article: 244
FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy
FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态
Giulia FuriniEduarda Mota da SilvaMargherita Maffei
Research 26 February 2026
Article: 243
fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial
功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验
Xudong ZhaoHetong ZhouMinmin Wang
Research 07 March 2026
Article: 242
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression
肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物
Nao-Xin HuangZi-Wei CaiHua-Jun Chen
Research 06 March 2026
Article: 241
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study
社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究
Yaguan ZhouHtet Lin HtunYi Guo
Research 06 March 2026
Article: 240
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China
中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究
Ruili LiXiaoguo ZhengXiaoning Lei
Research 06 March 2026
Article: 239
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童及青少年精神病学
Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis
静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析
Tianhao ZhangLin TongZhigang Liang
Research 06 March 2026
Article: 238
Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up
母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究
Joon Ho MoonHan Na JungSung Hee Choi
Research 06 March 2026
Article: 237
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题合集：妊娠期糖尿病的诊断与治疗
Parental income in childhood and health outcomes across age groups: a register-based study from Norway
童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究
Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn
Research 06 March 2026
Article: 236
AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China
基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究
Jianxin ZhaoYao TangYong Huang
Research 06 March 2026
Article: 235
Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery
回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Meiying CuiHang XuePing Zhao
Matters Arising 13 April 2026
Article: 234
Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis
无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解
Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw
Research 06 March 2026
Article: 233
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery
术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄
Fu-Shan XueDan-Feng WangXiao-Chun Zheng
Matters Arising 13 April 2026
Article: 232
Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London
他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究
Marc DelordAbdel Douiri
Research 05 March 2026
Article: 231
Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness
热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究
Jianming LiLu LiPing Liang
Research 05 March 2026
Article: 230
Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes
为何高胰岛素血症不利于减重：来自1型糖尿病的见解
Stephan MartinKerstin KempfHubert Kolb
Debate 10 April 2026
Article: 229
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减重干预措施及其健康影响
Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions
预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义
Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream
Forum 10 April 2026
Article: 228
Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study
奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究
Zihao GuoYuchen WeiKa Chun Chong
Research 17 March 2026
Article: 227
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS
瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据
Mozhu DingAlexandra WennbergKarin Modig
Research 08 April 2026
Article: 226
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial
超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验
Hongji ZengWeihong ZhangXi Zeng
Research 04 March 2026
Article: 225
Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution
双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变
Jin-Hua LiangYi-Fan WuWei Xu
Research 04 March 2026
Article: 224
Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study
BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究
Ruotong YangRobert J. MacInnisShuai Li
Research 04 March 2026
Article: 223
Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial
在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析
Songyue LiuYangzhi YinXiaofan Guo
Research 04 March 2026
Article: 222
The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations
慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用
Anne E. IoannidesEmily L. GraulJennifer K. Quint
Research 04 March 2026
Article: 221
Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study
伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究
Fotios BarkasMalo DirouKausik K. Ray
Research 03 March 2026
Article: 220
Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis
复发性呼吸道乳头瘤病新型预后评估工具的开发
Satoshi YamadaTaro IkegamiKiyoshi Misawa
Research 16 April 2026
Article: 219
Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study”
针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨
Julia StadelmaierGina BantleLukas Schwingshackl
Matters Arising 09 April 2026
Article: 218
Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al.
营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析
Matthew CalkinsIsaac NúñezAdrian Soto-Mota
Matters Arising 09 April 2026
Article: 217
Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study
多病共存模式与15年身体机能变化轨迹：一项基于人群的研究
Francesco PalmeseDavide Liborio VetranoFederico Triolo
Research 25 March 2026
Article: 216
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes
评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求
Ellen VercalsterenMichael V. MazyaCesare Patrone
Debate 24 March 2026
Article: 215
Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice
靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展
Jingjing ZhangXiangdong GongyeMargit Mahlapuu
Research 24 March 2026
Article: 214
Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project
多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果
Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero
Research 24 March 2026
Article: 213
Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma
胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响
Junyi ZhangJasmin von EhrYahaya A. Yabo
Research 13 March 2026
Article: 212
Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization
基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究
Martina BoukaKatharina NimptschTobias Pischon
Research 06 March 2026
Article: 211
Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS
血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来
Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli
Research 03 March 2026
Article: 210
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML
移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗
Shan JiangDan FengErlie Jiang
Research 03 March 2026
Article: 209
Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study
幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究
Naw Awn J-PKeiko YamasakiNarufumi Suganuma
Research 03 March 2026
Article: 208
Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study
抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究
Jinglei YuFengmei SongGuoqing Wei
Research 03 March 2026
Article: 207
Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics
通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序
Fanghao GuoDi SunWen Li
Research 03 March 2026
Article: 206
Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial
卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验
Zhiming ChenWenshuai LiJie Liu
Research 03 March 2026
Article: 205
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症临床试验
Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study
维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究
Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella
Research 03 March 2026
Article: 204
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病和心律失常
Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites
评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验
Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes
Research 02 March 2026
Article: 203
Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study
在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据
Wenlei YangMengfei LiuYang Ke
Research 02 March 2026
Article: 202
Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease
窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后
Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho
Research 28 February 2026
Article: 201
Anticholinergic drug burden and incident cardiovascular events: a population-based study
抗胆碱能药物负担与新发心血管事件：一项基于人群的研究
Nanbo ZhuMaria EriksdotterHong Xu
Research 28 February 2026
Article: 200
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study
从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究
Hui YangTongshuai GuoJianjun Mu
Research 27 February 2026
Article: 199
Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study
艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究
Jialing LinZhixuan KangFeifei Huang
Research 27 February 2026
Article: 198
Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria
揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析
Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest
Research 27 February 2026
Article: 197
Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy
基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况
Seung-Woo BaekYoung Joon ByunSeok Joong Yun
Research 27 February 2026
Article: 196
Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study
出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究
Lijie KongChun DouTiange Wang
Research 25 February 2026
Article: 195
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study
常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究
Xuxiang ShenYing SongXiangfeng Lu
Research 25 February 2026
Article: 194
Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder
自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后
Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg
Research 25 February 2026
Article: 193
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials
非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析
Jia SongHeng DongShangfeng Tang
Research 25 February 2026
Article: 192
Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures
皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层
Sixuan GuoYu ZhaoQiyong Gong
Research 25 February 2026
Article: 191
Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial
新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析
Tongzhen XuHuiying MaJing Jin
Research 25 February 2026
Article: 190
Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria
在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归
Inocência CuambaRebeca SantanoCarlota Dobaño
Research 31 March 2026
Article: 189
Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials
团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析
Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari
Research 24 February 2026
Article: 188
The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England
顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据
Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir
Research 24 February 2026
Article: 187
Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients
三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后
Ye WangPengyan WuBo Yu
Research 24 February 2026
Article: 186
Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids
靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性
Xiaoli ZhangWen ZhangHuiqin Guo
Research 24 February 2026
Article: 185
Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk
青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究
Yuan LiuMeijuan LiJie Li
Research 24 February 2026
Article: 184
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value
肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述
John K. JammalEsteban A. GomezAlfredo Iacoangeli
Review 23 February 2026
Article: 183
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题合集：肌萎缩侧索硬化症：最新进展与新动态
Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions
我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述
Rita GonçalvesM J MarquesSónia Dias
Research 23 February 2026
Article: 182
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation
促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证
Chang XuSuhail A. DoiPROMISE Collaborative Research Network
Research 21 February 2026
Article: 181
Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania
液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估
Jingjing JiangLiz MorrellAI-REAL Consortium
Research 21 February 2026
Article: 180
The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis
基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析
Fon-Yih TsuangYun-Heng LiChung Liang Chai
Research 21 February 2026
Article: 179
Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children
产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究
Lama A. ShakhshirSarjit SinghMichael Fleming
Research 20 February 2026
Article: 178
First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC
T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤
Dongmei JiWenmin FuXichun Hu
Research 20 February 2026
Article: 177
Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study
利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究
Chaoyue ChenZhouyang HuangJianguo Xu
Research 20 February 2026
Article: 176
Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization
20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化
Shan CaiJiaxin LiYi Song
Research 19 February 2026
Article: 175
Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis
抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析
Yike WuZihan WangGuo Ma
Research 19 February 2026
Article: 174
Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders
Yuefeng YuChenyi WanNingjian Wang
意义未明的克隆性造血与新发精神障碍风险
Research 18 February 2026
Article: 173
Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study
脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究
Yan-Ci ZhaoMin WangFeng Chen
Research 18 February 2026
Article: 172
Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study
弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究
Michael J. GreenLauren G. AndersonJonas J. Swartz
Research 18 February 2026
Article: 171
Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies
孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果
Jingnan ChenYidan DongJu-Sheng Zheng
Research 18 February 2026
Article: 170
Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications
更正：停用抗肥胖药物后体重的变化轨迹
Han WuWenjia YangLinong Ji
Correction 25 March 2026
Article: 169
Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study
超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究
Kai MuYanan QiaoBo Xi
Research 16 February 2026
Article: 168
Part of 1 collection:Weight loss interventions and their health impacts
所属专题合集：减肥干预措施及其对健康的影响
Maternal migraine and offspring ADHD: triangulating the evidence
母亲偏头痛与后代多动症（ADHD）：多方证据综合分析
Yaxin LuoChristina DardaniEvie Stergiakouli
Research 14 February 2026
Article: 167
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease
靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义
Lishan LinZhizong LiZhong Pei
Research 12 February 2026
Article: 166
Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates
颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案
A. LövgrenP. LivP. Svensson
Research 17 March 2026
Article: 165
Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study
可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究
Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative
Research 11 February 2026
Article: 164
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies
颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响
Yujing ChenZhaoyan LiuYu-ming Chen
Research 11 February 2026
Article: 163
Part of 1 collection:Climate change and human health
所属专题合集：气候变化与人类健康
Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands
荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益
Thomas OttenMirjam KnolAnneke Steens
Research 10 February 2026
Article: 162
Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis
睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析
Xiaoxiao MeiJinzhou YuZengjie Ye
Research 10 February 2026
Article: 161
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden
解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较
Shunsuke MurataMarcus EbelingKarin Modig
Research 23 March 2026
Article: 160
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用
The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics
青年睡眠模型：心理健康动态演变的因果环路图
Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod
Research 16 March 2026
Article: 159
Part of 1 collection:Sleep and mental health
所属专题合集：睡眠与心理健康
Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma
基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性
Daniel FeinbergVinayak UppinReshmi Parameswaran
Research 17 March 2026
Article: 158
Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial
涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验
Xinfei LiJun LiuKai Zhang
Research 09 February 2026
Article: 157
Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial
派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验
Jin-Hua LiangTong-Yao XingWei Xu
Research 09 February 2026
Article: 156
Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus
数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点
Jiaqi ZhangShuting HanTianzi Jiang
Research 10 February 2026
Article: 155
The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity
强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会
Rachel PecheyLauren BandySusan A. Jebb
Debate 10 February 2026
Article: 154
Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy
β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解
Zhe ChenYifan TangKai Xie
Research 09 February 2026
Article: 153
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa
优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析
Ginenus FekaduTadesse TolossaWai Kit Ming
Research 09 February 2026
Article: 152
Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort
基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解
Chan Soon ParkMoonyoung JangJun-Bean Park
Research 11 March 2026
Article: 151
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial
根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析
Lili WangYanguang LiYunlong Wang
Research 07 February 2026
Article: 150
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题合集：心肌病与心律失常
Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach
采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险
Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez
Research 07 February 2026
Article: 149
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与传染病
Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials
对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析
Liling ZengTong ZhouJing Li
Research 07 February 2026
Article: 148
Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma
布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性
Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong
Research 06 February 2026
Article: 147
Genetic risk factors modulate the association between physical activity and colorectal cancer
遗传风险因素调节身体活动与结直肠癌之间的关联
Anita R. PeoplesMireia Obón-SantacanaVictor Moreno
Research 05 February 2026
Article: 146
A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease
临床诊断阿尔茨海默病的疾病分期神经影像学标志物
Zhuangzhuang LiShaozhen YanYong Liu
Research 05 February 2026
Article: 145
Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation
胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究
Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei
Research 31 December 2025
Article: 144
Part of 1 collection:Diabetes and infectious disease
所属专题合集：糖尿病与感染性疾病
Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial
局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验
Hao XuFengyuan LiZekuan Xu
Research 26 February 2026
Article: 143
Part of 1 collection:Clinical trials for gastrointestinal cancer
所属专题合集：胃肠道癌症的临床试验
Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis
临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Research 28 February 2026
Article: 142
Part of 1 collection:Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics
ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解
Hua ShaoHanlu TangYongqing Xu
Research 04 February 2026
Article: 141
Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk
评估家族史和多基因风险评分对心代谢疾病风险的影响
Ebuka OnyenobiKnightess OyiboSally N. Adebamowo
Research 03 February 2026
Article: 140
Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP)
社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据
Chen ShenBraulio M. Girela-SerranoMireille B. Toledano
Research 03 February 2026
Article: 139
Part of 1 collection:Child and adolescent psychiatry
所属专题合集：儿童与青少年精神病学
Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel
使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测
Qiong LuoJuan WeiXuefeng B. Ling
Research 02 February 2026
Article: 138
Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study
一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系
Ming WangYixiang XuFei Li
Research 02 February 2026
Article: 137
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法
Objective assessment of long-term impact of COVID-19 on multiple sensory functions
客观评估新冠肺炎对多种感觉功能的长期影响
Ahmad OdehVeronica L. FormanekKai Zhao
Research 27 February 2026
Article: 136
Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis
急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析
Luisa F. AlvizCarla Y. KimKiran T. Thakur
Review 28 February 2026
Article: 135
Part of 1 collection: Acute meningitis: a collection of systematic reviews
所属专题合集：急性脑膜炎：系统综述合集
Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities
血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担
Preeti MoarChristoffer GranvikMattias N. E. Forsell
Research 24 February 2026
Article: 134
Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study
父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究
Mengping ZhouHenrik LarssonErik Pettersson
Research 26 February 2026
Article: 133
Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis
外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析
Blossom C. M. StephanJacob BrainMario Siervo
Research 02 February 2026
Article: 132
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用
Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study
静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究
Ga Won YimKyung Hee HanHee Seung Kim
Research 02 February 2026
Article: 131
Time for change in implementation research and practice
实施研究和实践中变革的时机已到
Mike EnglishJacob McKnightSebastian Fuller
Debate 02 February 2026
Article: 130
CardioMetAge estimates cardiometabolic aging and predicts disease outcomes
CardioMetAge可评估心脏代谢年龄并预测疾病结局
Yucan LiXinming XuKelin Xu
Research 31 January 2026
Article: 129
Disproportionate climate burden of rising temperatures on low birth weight in Pakistan
气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担
Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi
Research 31 January 2026
Article: 128
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy
利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示
Zhongyi DongHaoyu ZhangZizhen Zhang
Research 30 January 2026
Article: 127
Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma
靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用
Qinghua ZengYan ZhangYonghan He
Research 30 January 2026
Article: 126
Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4
DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究
Liye LaiAngelina Shin Yee JongMelanie Waldenberger
Research 04 February 2026
Article: 125
Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis
精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解
Jiahang SongPengzhu LiOlivier Gires
Research 05 February 2026
Article: 124
Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用
Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children
宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究
Muhammad Zakir HossinMartina PerssonNeda Razaz
Research 14 February 2026
Article: 123
ADHD and adherence to antihypertensive medication treatment: a multinational cohort study
多动症与坚持抗高血压药物治疗的关系：一项多国队列研究
Honghui YaoYiling ZhouZheng Chang
Research 20 February 2026
Article: 122
How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project
重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目
Hadar KleinDafna PachterIris Shai
Research 30 January 2026
Article: 121
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减肥干预措施及其对健康的影响
Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings
更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆
Feiwen WangJie YangLena Palaniyappan
Correction 20 February 2026
Article: 120
Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities
作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识
Manuel SpitschanAnna M. BillerJohannes Zauner
Guideline 29 January 2026
Article: 119
Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study
青少年饮食模式与神经心理功能：一项横断面和纵向研究
Alexios ManidisNicolas Ayala-AldanaJordi Julvez
Research 29 January 2026
Article: 118
Part of 1 collection: Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals
影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究
Linda ModderkolkYvonne SchoonAnne B. Wichmann
Research 29 January 2026
Article: 117
Part of 1 collection: Palliative care and medicine
所属专题：姑息治疗与医学
Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews
针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价
Jasmine LeePhoebe BarnettSonia Johnson
Research 29 January 2026
Article: 116
Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone
局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解
Lingli HuLingqi YeShuang Wang
Research 28 January 2026
Article: 115
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题合集：癫痫：发作预防、治疗和流行病学
Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial
有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验
Alexander HaussmannMartina E. SchmidtKaren Steindorf
Research 28 January 2026
Article: 114
Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis
中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构
Yige LiuJiaxin WangShaohong Fang
Research 28 January 2026
Article: 113
Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort
分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究
Camille GiampiccoloBéatrice FerversAmina Amadou
Research 28 January 2026
Article: 112
Part of 1 collection: Carcinogens and human health
所属专题合集：致癌物与人类健康
Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review
针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述
Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury
Research 16 February 2026
Article: 111
Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern
以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾
Sergio A. SilverioJulia R. B. BrownEmma L. Duncan
Research 24 February 2026
Article: 110
Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives
气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查
Andrew HantelEmily SenayGregory A. Abel
Research 27 January 2026
Article: 109
Part of 1 collection: Climate change and human health
所属专题：气候变化与人类健康
Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study
伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究
Huimin LvTao SunMin Yan
Research 27 January 2026
Article: 108
Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom
早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究
Catherine A. ScottLinxin LiPeter M. Rothwell
Research 24 January 2026
Article: 107
Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis
盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析
Honghao LaiGihad NesrallahBradley C. Johnston
Research 23 January 2026
Article: 106
Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China
短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据
Mengxin WangAogang ZhangWeidong Wu
Research 23 January 2026
Article: 105
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial
辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验
Yun FengNing ZhangLu Wang
Research 23 January 2026
Article: 104
Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study
袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究
Yutung YenQian ZhangYi Chen
Research 22 January 2026
Article: 103
Part of 1 collection:Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial
性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解
Ping WangJingyu ZhouLing Tao
Research 22 January 2026
Article: 102
Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models
通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况
Xueting WangJun HeRenato Polimanti
Research 22 January 2026
Article: 101
Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition
严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关
Brenda KamauEvans O. MudiboJames M. Njunge
Research 22 January 2026
Article: 100
Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Correction 14 February 2026
Article: 99
Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults
仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究
Jonathan R. OlsenNatalie NichollsRichard Mitchell
Research 21 January 2026
Article: 98
Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial
在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析
Weiqin LiHuikun LiuGang Hu
Research 21 January 2026
Article: 97
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与治疗
Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study
心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解
Jing ChenZhu LiGregory Y. H. Lip
Research 20 January 2026
Article: 96
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain
斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究
Marta CarrascoBogdan VlachoMarta Hernández
Research 20 January 2026
Article: 95
Part of 1 collection: Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England
为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究
A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement
Research 22 January 2026
Article: 94
Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial
爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验
Jiao QinChunxing TaoBingyu Liang
Research 19 January 2026
Article: 93
The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications
电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析
Quan WangZheng ZhuLi Yang
Research 17 January 2026
Article: 92
Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study
抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究
Xiaoyu LiRuihong DaiFeng Bi
Research 16 January 2026
Article: 91
Part of 1 collection: Clinical trials for gastrointestinal cancer
所属专题：胃肠道癌症临床试验
Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study
比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究
Carlos Raul Ramirez MedinaMark LuntMeghna Jani
Research 31 January 2026
Article: 90
Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors
接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联
Masashi KubotaSatomi YoshidaKoji Kawakami
Research 16 January 2026
Article: 89
Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China
高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究
Junyi XieZhenhua LiuWei Yu
Research 16 January 2026
Article: 88
Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis
204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析
Weiyang ChenMin DuJue Liu
Research 15 January 2026
Article: 87
Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study
肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究
Chenhao FangJiaoting JinShuoqiu Gan
Research 15 January 2026
Article: 86
Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial
重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验
Lijiao MengRaymond C. C. TsangQuan Wei
Research 14 January 2026
Article: 85
5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice
中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病
Qi ZhangLi XieRiyue Jiang
Research 13 January 2026
Article: 84
The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome
POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析
Ting XuXuhui ZhangJian Li
Research 13 January 2026
Article: 83
The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial
度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验
Shengyuan WangHeng WuXianghuai Xu
Research 13 January 2026
Article: 82
Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial
心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析
Manlin ZhaoYang ChenGregory Y. H. Lip
Research 12 January 2026
Article: 81
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss
母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关
Zhangwei JiaJunxiang RenJunhao Yan
Research 12 January 2026
Article: 80
Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer
幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联
Keren JiaYang ChenLin Shen
Research 12 January 2026
Article: 79
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物组：人类疾病的新疗法
SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis
SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响
Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai
Research 12 January 2026
Article: 78
Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review
从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界
Bibiana BielekovaTianxia WuMichael Calcagni
Research 10 January 2026
Article: 77
A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data
利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型
Sonja KatzJaco SuijkerEdoardo Saccenti
Research 10 January 2026
Article: 76
Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis
中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析
Xin ZhaoShujing WuJunbo Ge
Research 09 January 2026
Article: 75
Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023
2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障
Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés
Research 09 January 2026
Article: 74
Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models
昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析
Mrinal K. DasEvi De RyckJohanna Samulin Erdem
Research 09 January 2026
Article: 73
Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults
衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用
Rafael Ogaz-GonzálezQian ZouEva Corpeleijn
Research 08 January 2026
Article: 72
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials
益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析
Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy
Research 07 January 2026
Article: 71
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life
澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系
Grace JoshySaman Khalatbari-SoltaniEmily Banks
Research 22 January 2026
Article: 70
Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong
与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据
Boyuan WangTingting ChenEric Yuk Fai Wan
Research 06 January 2026
Article: 69
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study
长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究
Bo YinQi HuangKuiying Gu
Research 06 January 2026
Article: 68
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach
利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制
Tianyang ChenDalong LiuXiangYang Leng
Research 03 January 2026
Article: 67
Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study
Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究
Xingru LongShuxian AnDawei Jiang
Research 31 December 2025
Article: 66
Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker
甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物
Shanjie WangJunChen GuoShaohong Fang
Research 31 December 2025
Article: 65
Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial
术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验
Meiying CuiHang XuePing Zhao
Research 31 December 2025
Article: 64
Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies
所属专题：精神活性物质：将娱乐性药物重新用于新型疗法
Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women
中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究
Yanrui BiYuan MaYing Gao
Research 30 December 2025
Article: 63
Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C
心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比
Nicole L. De La MataJames A. HedleyJennifer S. Lees
Research 30 December 2025
Article: 62
The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden
锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据
Huan YiJimiao HuangJianguang Ji
Research 29 December 2025
Article: 61
Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study
胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究
Peilin ZhouWenqiang WangQikai Hua
Research 28 December 2025
Article: 60
Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study
卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究
Jinhong ZhuJinfeng ZhangJianqun Ma
Research 28 December 2025
Article: 59
Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies
50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现
Xiaosheng DongJiaqiang XiaoChengchao Zhou
Research 28 December 2025
Article: 58
Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease
现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况
Michael HolderDaniel R. MoralesBruce Guthrie
Research 27 January 2026
Article: 57
Polygenic risk score-guided personalized osteoporosis screening: a population-based study
基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究
Dongxue WangWen SunJianguang Ji
Research 14 January 2026
Article: 56
Urea cycle modulation by combined SGLT2 inhibitors and metformin
SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用
Makoto HaradaJonathan AdamRui Wang-Sattler
Research 08 January 2026
Article: 55
Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study
VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究
Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez
Research 10 January 2026
Article: 54
Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial
为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验
Julian HerterFrieda StübingMaximilian Andreas Storz
Research 10 January 2026
Article: 53
Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II
社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果
Ingmar SchäferValentina PauckeDagmar Lühmann
Research 15 January 2026
Article: 52
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis
孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析
Loviisa MulanjeLara Kim BrackmannRajini Nagrani
Research 14 January 2026
Article: 51
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients
分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究
Alexander ScheiterSimon MellinKirsten Utpatel
Research 14 January 2026
Article: 50
Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022
计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定
Richard WenAnteneh Tesfaye AssalifRashid Ansumana
Research 24 December 2025
Article: 49
Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank
Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解
Wei-Ming SuQing-Qing DuanYong-Ping Chen
Research 24 December 2025
Article: 48
Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates
所属专题：肌萎缩侧索硬化症：最新进展与新动态
Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner
产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育
Ying DongStefan HadzicSaverio Bellusci
Research 22 December 2025
Article: 47
Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study)
27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究）
Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach
Research 20 December 2025
Article: 46
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Validation of a novel patient-reported measure of the burden of digital care in diabetes
由糖尿病患者报告的数字化护理负担新型测评工具的验证
Misk Al ZahidyJennifer L. RidgewayVictor M. Montori
Research 20 December 2025
Article: 45
Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa
撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素
Víctor L. de RiojaOdin GoovaertsGemma Moncunill
Research 14 January 2026
Article: 44
Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial
卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验
Xin ZhangDi SunYansong Lin
Research 18 December 2025
Article: 43
Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial
地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验
Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós
Research 18 December 2025
Article: 42
Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention
经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证
Hualong MaCong PengQiaohong Yang
Research 18 December 2025
Article: 41
DNA methylation-based clocks, tobacco smoking, and lung cancer risk
基于DNA甲基化的生物钟、烟草吸烟与肺癌风险
Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson
Research 17 December 2025
Article: 40
Part of 1 collection:Carcinogens and human health
所属专题：致癌物与人类健康
Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old
认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素
Giulia LorenzonAnna MarsegliaEric Westman
Research 17 December 2025
Article: 39
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学和风险因素的作用
Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study
基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究
Wanzhou WangChao YangLuxia Zhang
Research 16 December 2025
Article: 38
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity
针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫
Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno
Research 15 December 2025
Article: 37
Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib
达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性
Shi-yu HuangMin HuLei Wang
Research 15 December 2025
Article: 36
Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study
新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究
Fangzhou LiuPing JiangLing Liu
Research 13 December 2025
Article: 35
Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology
所属专题：癫痫：癫痫发作的预防、治疗和流行病学
Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study
基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析
Coraline DubotIsabelle Ray-CoquardFlorence Joly
Research 12 December 2025
Article: 34
Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi
非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究
Wei WeiChunrong GuiBaoheng Gui
Research 12 December 2025
Article: 33
Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic?
高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？
Janis TimsansJenni Emilia KauppiMarkku Kauppi
Research 11 December 2025
Article: 32
Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses
社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究
Tingshan DuanZhi CaoChenjie Xu
Research 10 December 2025
Article: 31
Digital marketing techniques within online food retail platforms: a scoping review
在线食品零售平台中的数字营销技巧：一项范围综述
Adyya GuptaCatherine E. HugginsAnna Peeters
Research 10 December 2025
Article: 30
Dramatic increases in redundant publications in the Generative AI era
生成式人工智能时代冗余出版物数量急剧增加
Danny MaupinTulsi SuchakMatt Spick
Research 09 December 2025
Article: 29
Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform
意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现
Matteo LandolfoAlessandro GezziRiccardo Sarzani
Research 09 December 2025
Article: 28
Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial
Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验
Yue ChengHonghu TangYi Liu
Research 09 December 2025
Article: 27
Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants
子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应
Xuemin WangLaure DossusTracy A. O’Mara
Research 10 February 2026
Article: 26
Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice
孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关
Bekalu Kassie AlemuChi Chiu WangYao Wang
Research 08 December 2025
Article: 25
Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures
绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征
Patrick PirrotteBrooke LovellJohanna K. DiStefano
Research 07 December 2025
Article: 24
Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021
基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析
Shenghao XuJing WangJianlin Xiao
Research 07 December 2025
Article: 23
Part of 1 collection:Climate change and human health
所属专题：气候变化与人类健康
Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models
亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭
Xiao ZongXierenayi TudiRong Tao
Research 07 December 2025
Article: 22
Part of 1 collection:Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial
常压高氧治疗脑出血：一项随机临床试验
Zhiying ChenJiayue DingRan Meng
Research 07 December 2025
Article: 21
Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database
Emmanuelle LogeaisFrançoise TroussierLilia Khendek
2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究
Research 05 December 2025
Article: 20
Part of 1 collection:Child and adolescent psychiatry
所属专题：儿童与青少年精神病学
Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial
盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估
Carol BuggeMelanie Dembinskythe TOPSY team
Research 05 December 2025
Article: 19
Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study
大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究
Kaixing LeYaru LiuZhigang Liu
Research 05 December 2025
Article: 18
Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis
1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析
Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso
Review 05 December 2025
Article: 17
Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain
差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异
Sarah E. JacksonCaitlin NotleySharon Cox
Research 10 February 2026
Article: 16
Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression
SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果
Lingling GaoJie JiangXuchao Zhang
Research 03 December 2025
Article: 15
Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program
“我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系
Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy
Research 03 December 2025
Article: 14
Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias
用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系
Pei QinFrederick K. HoJill P. Pell
Research02 December 2025
Article: 13
Part of 1 collection: Cardiomyopathy and cardiac arrhythmias
所属专题：心肌病与心律失常
KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population
KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究
Dabin YunKwangyeon OhNan Song
Research 03 December 2025
Article: 12
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学及风险因素的作用
Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants
睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究
Stephanie YiallourouLachlan CribbMatthew P. Pase
Research 03 December 2025
Article: 11
Part of 1 collection: Sleep and mental health
所属专题：睡眠与心理健康
Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer
肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用
Ya-Ting ChenJing SuiEvan Yi-Wen Yu
Research 03 December 2025
Article: 10
Part of 1 collection: Gut microbiota: New treatments of human disease
所属专题：肠道微生物群：人类疾病的新疗法
A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA
基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县
Anqi ZhuBibhas ChakrabortyTazeen H. Jafar
Research 02 December 2025
Article: 9
HIV infection and immunosenescence: challenges and intervention strategies
HIV感染与免疫衰老：挑战与干预策略
Junyan JinQianqian XuBin Su
Review 02 December 2025
Article: 8
Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors
所属专题：健康老龄化与长寿：预防医学与风险因素的作用
Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators
基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究
Weichong ZhouCong PengHui Shi
Research 29 November 2025
Article: 7
The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial
基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验
Paul DoodyGina M. WrenPaul Aveyard
Research 29 November 2025
Article: 6
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults
脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究
Xue DongPaul AveyardMin Gao
Research 29 November 2025
Article: 5
Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial
标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验
Xinyi WangKe QiuYu Zhao
Research 28 November 2025
Article: 4
Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia
澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况
Tim Adair
Research 29 January 2026
Article: 3
Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study
评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究
Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges
Research 14 January 2026
Article: 2
Part of 1 collection:Diagnosis and management of gestational diabetes
所属专题：妊娠期糖尿病的诊断与管理
Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain
胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究
Sarah E. JacksonJamie BrownLion Shahab
Research 08 January 2026
Article: 1
Part of 1 collection: Weight loss interventions and their health impacts
所属专题：减重干预措施及其对健康的影响
2026-07-21
iStock,
Vladimir Vinogradov
The biopharma industry would do well to re-embrace the 505(b)(2) path, which allows sponsors to draw on previous findings around an existing drug even as they propose modifications to it.
In a capital environment defined by caution, skepticism and heightened demand for controlled risk, FDA’s 505(b)(2) pathway stands as one of the few remaining regulatory levers capable of accelerating innovation with some level of capital protection. Designed to enable sponsors to leverage existing efficacy and safety data for approved drugs while introducing meaningful modifications, the pathway can reduce development timelines for new therapies by several years and cut costs by tens to hundreds of millions of dollars relative to a 505(b)(1) New Drug Application.
A few recent 505(b)(2) success stories illustrate how the pathway can translate into meaningful commercial outcomes when paired with clear differentiation. Pacira BioSciences’ Exparel is a long-acting liposomal formulation of the local anesthetic bupivacaine, indicated for postsurgical analgesia. By extending duration of action in a well-understood class, it enabled opioid-sparing protocols and became a cornerstone in perioperative pain management with strong hospital adoption. Xywav, by Jazz Pharmaceuticals, is a reformulated oxybate therapy for narcolepsy and idiopathic hypersomnia with approximately 92% less sodium than its predecessor; this clinically meaningful safety improvement drove rapid patient conversion and sustained franchise growth. And Axsome Therapeutics’ Auvelity combines two established agents into a novel NMDA-modulating antidepressant for major depressive disorder, delivering faster onset and differentiated efficacy compared to either drug by itself.
Across these cases, success stems from the same principle: reformulating or recombining validated drugs within established classes to deliver tangible clinical or economic advantages
that resonate with prescribers, patients and payers.
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Yet despite its track record of success and its contribution to the majority of NDAs in recent years (
approximately 57% in 2024
), we have observed in our consulting work at InnoDev that the 505(b)(2) pathway seems to have been re-assessed by the industry, sometimes dismissed as a shortcut at best with little upside, or other times underappreciated as an indicator that a drug is not novel.
Investors have historically viewed 505(b)(2) assets with cautious optimism. On paper, the economics are striking: Published analyses suggest that repurposed medicines can reach the market with average development costs of roughly
U$300 million
—compared with $2–3 billion for a novel molecular entity—while also benefiting from substantially lower development risk because human safety data already exist.
That relatively low risk comes with a few trade-offs. Short exclusivity windows, generic vulnerability and regulatory uncertainty stemming from the current regulatory and political environment at FDA, and from relying on public data from prior FDA reviews, which might be incomplete and mask gaps or post‑marketing safety issues that emerge during review. Because bridging needs vary widely based on how a product differs from its reference, the scope of required studies may turn out to be more significant than expected and constrain long-term upside.
The investor calculus is thus nuanced: 505(b)(2)s are compelling for near-term monetization or niche markets, but are rarely the foundation for enduring franchises unless coupled with proprietary technology or platform innovation.
As advisors in this space working at InnoDev Partners, we experience the same conundrum observed in the industry: should we continue to lean on the pathway as a way to bring meaningful therapies to market in areas of unmet need, or should we discourage inventors and founders from pursuing development programs aimed at the 505(b)(2) pathway in favor of drugs seen as more innovative? As laid out below, we believe that in the right circumstances, the 505(b)(2) pathway remains a useful tool to push forward innovation.
A hybrid route with strategic advantages
A 505(b)(2) filing occupies a unique middle ground between the “stand-alone” 505(b)(1) New Drug Application and the generic 505(j) Abbreviated NDA, leveraging prior FDA findings of safety and efficacy from a listed drug while allowing meaningful product modification. This hybrid approach makes it possible to bring improved formulations, new delivery systems or new indications to patients faster and at a fraction of the traditional cost.
The regulatory advantage is significant. By referencing existing data, sponsors reduce the need for large, costly Phase 3 trials and shorten timelines, sometimes by several years. The outcome is not merely a faster path to approval but a materially lower cost of development, often reducing outlay from over a billion dollars to under $50 million. For early-stage biopharma, that delta can mean the difference between failure, and staying solvent and achieving market entry.
Operational efficiency and program agility
From an operational perspective, the 505(b)(2) model transforms the very architecture of drug development. Instead of building a program from the ground up, teams design efficient bridging strategies that focus on regulatory justification and data alignment. Program management becomes a discipline of integration: synchronizing chemistry, manufacturing and controls readiness, regulatory engagement and clinical pharmacology to ensure that every reference to existing data is scientifically defensible.
This streamlined model encourages faster decision-making and tighter cross-functional coordination. Compared with the long, risk-laden timelines of a new chemical entity, 505(b)(2) development can move with startup-like agility while still meeting FDA rigor.
Commercial promise—and its caveats
Commercially, 505(b)(2) programs offer a rare alignment of regulatory speed, clinical logic and economic efficiency. For investors, they represent tangible, near-term value inflection points: earlier proof of concept, faster time to revenue and often lower biological risk. Indeed, when executed correctly—with strong differentiation and clear payer logic—the pathway can yield some of the most capital-efficient successes in biopharma.
Yet the same factors that make the model appealing also invite scrutiny. Market exclusivity, typically three to five years after approval of a 505(b)(2) application, is limited compared to the 12-year protection of drugs approved under standalone NDAs. Relying on known active ingredients weakens the intellectual-property moat, making differentiation essential. Products that fail to deliver meaningful clinical or economic advantages risk being seen as incremental and priced accordingly. In saturated markets, even a modestly improved therapy can be commercially overlooked if the value story is not compellingly built for prescribers, payers and patients.
When to choose the 505(b)(2) route
The 505(b)(2) framework is not a regulatory loophole, but an instrument of purposeful innovation. When used well—to advance patient access, reduce costs of care or modernize delivery—it embodies the very spirit of pragmatic innovation the healthcare system needs. But sponsors must resist the temptation to treat it as a shortcut to market. The FDA has grown more demanding, requiring robust bridging data and meaningful differentiation. The sponsor of a 505(b)(2) application needs to carefully consider the strategy, and factors such as: what data are available, and are those data sufficient for the regulatory agency to bridge to the new application? Is the return on investment sufficient for the estimated time and costs of development?
Those who invest early in clinical, regulatory and market access clarity will find the pathway not just viable, but transformative. As the biopharma ecosystem faces escalating capital scarcity and payer pressure, the industry would do well to re-embrace the 505(b)(2) path, not as a second-tier route, but as a strategy to deliver smarter innovation faster. For founders, investors and regulators alike, that shift in mindset could redefine how value, risk and speed are balanced in the next wave of therapeutic advancement.
申请上市
100 项与 羟丁酸钠 相关的药物交易
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 猝倒症 | 欧盟 | 2005-10-13 | |
| 猝倒症 | 冰岛 | 2005-10-13 | |
| 猝倒症 | 列支敦士登 | 2005-10-13 | |
| 猝倒症 | 挪威 | 2005-10-13 | |
| 发作性睡病 | 美国 | 2002-07-17 |
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 戒酒 | 申请上市 | 欧盟 | 2019-10-17 | |
| 物质戒断综合征 | 申请上市 | 欧盟 | 2019-10-17 | |
| 特发性睡眠过度 | 临床3期 | 美国 | 2024-08-01 | |
| 白天过度嗜睡 | 临床3期 | 美国 | 2016-11-17 | |
| 白天过度嗜睡 | 临床3期 | 澳大利亚 | 2016-11-17 | |
| 白天过度嗜睡 | 临床3期 | 加拿大 | 2016-11-17 | |
| 白天过度嗜睡 | 临床3期 | 捷克 | 2016-11-17 | |
| 白天过度嗜睡 | 临床3期 | 法国 | 2016-11-17 | |
| 白天过度嗜睡 | 临床3期 | 德国 | 2016-11-17 | |
| 暴食症 | 临床3期 | 美国 | 2007-08-01 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床3期 | 50 | 觸鬱鹹簾淵鏇艱醖繭憲(衊淵範繭艱鏇鏇衊鹽鬱) = 膚齋齋鏇鑰廠鬱糧艱鹽 壓膚繭醖網壓構簾簾選 (襯願鹹齋艱窪壓醖製遞, -12.1 ~ -4.6) 更多 | 积极 | 2026-04-25 | |||
临床4期 | - | 22 | 襯憲壓構艱蓋願鏇構夢(願鬱廠憲艱觸顧衊鬱顧) = 壓築衊願蓋繭遞繭顧夢 憲壓鏇獵襯遞構選構餘 (觸顧艱積夢積衊衊餘壓, 71.5 ~ 100) | 积极 | 2025-12-21 | ||
Midazolam | 襯憲壓構艱蓋願鏇構夢(願鬱廠憲艱觸顧衊鬱顧) = 糧艱鹽顧鏇鬱鬱範顧淵 憲壓鏇獵襯遞構選構餘 (觸顧艱積夢積衊衊餘壓, 0 ~ 28.5) | ||||||
临床3期 | 130 | 齋繭憲鹹獵窪齋憲鬱衊(鬱獵夢簾憲簾繭廠構顧) = 觸憲遞繭獵醖網窪憲遞 選襯鹽範夢淵齋夢選窪 (構繭鹽襯壓鑰鬱齋糧構 ) | 积极 | 2025-09-05 | |||
N/A | 67 | 醖遞願範鹽醖顧醖鑰窪(鹽憲選壓積構願簾醖繭) = 餘鑰齋簾觸衊遞襯膚願 網願積鏇壓願鹹衊選鑰 (構夢顧襯膚選醖選選窪 ) 更多 | 积极 | 2025-09-05 | |||
临床3期 | 50 | 壓構構廠鬱簾築餘繭願(簾鏇範夢衊願鹽網襯淵) = 選憲鬱艱積製蓋鏇蓋繭 製觸夢製遞廠構廠簾積 (憲鹹顧遞網淵襯製鬱網 ) 更多 | 积极 | 2025-09-05 | |||
临床3期 | - | 鏇憲膚醖餘範襯鹽艱壓(構繭淵願淵願簾製鏇範): P-Value = 0.522 更多 | 积极 | 2025-04-07 | |||
Placebo | |||||||
临床3期 | 89 | 遞鬱壓顧獵憲繭構憲窪(觸願鬱獵廠簾願遞願遞) = 繭鹹鏇積選衊範鏇壓繭 膚遞糧醖鬱願衊築鑰鏇 (積蓋餘願獵鏇襯衊餘蓋 ) 更多 | 积极 | 2025-04-07 | |||
Literature 人工标引  | 临床2期 | 106 | (EtOH+) | 襯襯窪廠獵範蓋觸網醖(衊遞鏇蓋鬱衊簾壓餘積) = 選網築積網衊廠觸餘膚 獵鹹蓋淵簾簾鏇夢淵艱 (鹹壓製範範鏇觸鑰願積 ) | 积极 | 2024-11-20 | |
(EtOH-) | - | ||||||
临床3期 | 212 | 齋夢壓鹽餘憲鬱範鑰糧(獵襯艱遞窪鑰憲糧襯醖) = 衊餘齋簾糧艱顧淵選糧 醖範積觸齋願蓋觸範廠 (壓廠獵夢鬱獵蓋窪構繭 ) 更多 | 积极 | 2024-08-20 | |||
Placebo | 齋夢壓鹽餘憲鬱範鑰糧(獵襯艱遞窪鑰憲糧襯醖) = 衊顧壓觸醖襯構鹽憲窪 醖範積觸齋願蓋觸範廠 (壓廠獵夢鬱獵蓋窪構繭 ) 更多 | ||||||
临床3期 | - | 願繭糧艱鏇鏇獵觸觸選(築蓋鏇積顧觸壓範選窪) = 廠蓋選淵衊夢鑰鏇糧糧 膚衊夢築獵淵糧鑰構艱 (憲鑰蓋鬱廠糧繭遞夢鏇, 0.13) 更多 | 积极 | 2024-08-16 | |||
Placebo | 願繭糧艱鏇鏇獵觸觸選(築蓋鏇積顧觸壓範選窪) = 憲餘窪窪窪製艱鹽製蓋 膚衊夢築獵淵糧鑰構艱 (憲鑰蓋鬱廠糧繭遞夢鏇, 0.13) 更多 |
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