Trauma is the leading cause of death and disability in children in the United States. The objective of this study is to evaluate the benefits and harms of tranexamic acid (TXA; a drug that stops bleeding) in severely injured children with hemorrhagic brain and/or torso injuries. Using thromboelastography, we will measure baseline fibrinolysis to assess for treatment effects of TXA at different levels of fibrinolysis.

开始日期2026-10-01

申办/合作机构

University of California, Davis

NCT07685743

/ Not yet recruiting临床4期IIT

Extended Post-operative Oral TXA vs.Standard Perioperative TXA in Primary TJA: A Randomized, Double-Blind, Placebo-Controlled Trial

The goal of this clinical trial is to learn if extended post-operative oral tranexamic acid (TXA) - a medication that reduces bleeding by slowing the breakdown of blood clots - can improve functional recovery following surgery in adults undergoing primary total knee or hip arthroplasty for osteoarthritis. The main question it aims to answer is: Does extended post-operative oral TXA improve functional outcomes at 6 weeks post-operatively compared to standard perioperative TXA alone? Researchers will compare patients receiving extended oral TXA to patients receiving matching placebo capsules on the same schedule to see if the extended TXA regimen reduces blood loss, improves early functional outcomes, and reduces pain without increasing complication rates. Participants will receive standard perioperative oral TXA (1.95 g) prior to surgical incision, along with standard VTE prophylaxis. They will be randomly assigned to receive either oral TXA or matching placebo capsules once daily on post-operative days 1, 2, and 3. Participants will attend follow-up visits at 2, 6, and 12 weeks post-operatively to complete functional outcome questionnaires, pain assessments, and - for knee replacement patients - range of motion measurements.

开始日期2026-09-01

申办/合作机构

Oregon Health & Science University

100 项与氨甲环酸相关的临床结果

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100 项与氨甲环酸相关的转化医学

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100 项与氨甲环酸相关的专利（医药）

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8,327

项与氨甲环酸相关的文献（医药）

2026-12-31·JOURNAL OF DERMATOLOGICAL TREATMENT

Clinical outcomes of intense pulsed light combined with non-crosslinked sodium hyaluronate, tranexamic acid, and vitamin C mesotherapy for facial photoaging: a retrospective study

Article

作者: Li, Fei ; Xu, Jialu ; Wu, Xixin ; Wu, Yutong ; Qiu, Houhuang ; Wang, Fangfang ; Xu, Tianhua ; Chen, Xi ; Zhong, Ping ; Lin, Qiusheng

BACKGROUND:

Facial photoaging involves structural and functional deterioration across multiple skin layers. Single-modality treatments rarely address pigmentary, vascular, and dermal matrix changes concurrently. Intense pulsed light (IPL) is widely used for the treatment of dyschromia and vascular lesions. Mesotherapy incorporating non-crosslinked sodium hyaluronate (NCSH), tranexamic acid (TXA), and vitamin C (VC) has been introduced to improve skin hydration and related dermal parameters. The present study assessed the efficacy and safety of combining these modalities for facial rejuvenation.

METHODS:

Eighty-four patients underwent three sessions of IPL with mesotherapy. Standardized VISIA imaging was conducted before each treatment (T0, T1, T2) and at 1-2 months (T3) and 3-6 months (T4) post-treatment. Efficacy was assessed using the Modified Fitzpatrick Wrinkle Scale (MFWS) and Global Aesthetic Improvement Scale (GAIS); adverse events and satisfaction were recorded.

RESULTS:

All six VISIA parameters and MFWS scores improved significantly (p __-mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"-__<0.001), peaking at T3 with mild non-significant rebound at T4. GAIS and satisfaction assessments confirmed consistent aesthetic improvement. No severe adverse events occurred; transient burning, papular reactions, and erythema were most common. The overall satisfaction rate was 82.15%.

CONCLUSIONS:

IPL combined with NCSH/TXA/VC mesotherapy provided safe, effective, and well-tolerated improvement in facial photoaging, representing a promising multimodal rejuvenation approach.

2026-12-31·ANNALS OF MEDICINE

Tranexamic acid in spontaneous intracerebral hemorrhage: an updated systematic review and meta-analysis of randomized controlled trials

Review

作者: Liu, Zhenhong ; Que, Cuilin ; Lai, Xinxing ; Gao, Ying ; Feng, Luda ; Zhang, Hongrui ; Kong, Lingbo ; Gao, Yonghong ; Tao, Chenxi

BACKGROUND:

Tranexamic acid (TXA) is a well-established antifibrinolytic medication in the general population. However, its efficacy and safety for patients with spontaneous intracerebral hemorrhage (ICH) remain inconclusive. Consequently, we conducted a systematic review and meta-analysis to assess the effectiveness and safety of TXA for spontaneous ICH.

METHODS:

We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) following established methodological standards. Our search encompassed eight electronic databases from inception to April 25, 2024. The primary outcome was a reduction in all-cause mortality. The secondary outcomes included improvements in functional independence, neurological impairment, activities of daily living, and reduction in hematoma expansion (HE). Fixed-effects or random-effects model were performed for pooled data where eligible.

RESULTS:

A total of 9 RCTs that initially enrolled 3,124 patients were included. There were no significant differences observed concerning all-cause mortality (RR, 1.03; 95% CI [0.89-1.18]), hematoma expansion (RR, 0.90; 95% CI [0.80-1.00]), improvement of functional independence (RR, 1.02; 95% CI [0.92-1.12], neurological impairment (MD, -0.88 [95% CI, -2.22-0.45]), or activities in daily living (MD, -0.83 [95% CI, -29.25-12.59]). The pooled data indicated that TXA for ICH was associated with a decrease in hematoma volume from baseline (MD, -1.74; 95% CI [-2.47 to -1.02]). No significant difference in adverse events was observed between the TXA group and the control group.

CONCLUSIONS:

In summary, TXA does not affect all-cause mortality, functional outcomes, or neurological impairment, nor does it reduce HE, despite reducing hematoma volulume. TXA use for ICH requires careful clinical consideration.

2026-12-31·JOURNAL OF DERMATOLOGICAL TREATMENT

Exploring the mechanism of differential responses to combination therapy in melasma: pigmentary versus mixed pigmentary–vascular types—a clinical study based on interaction analysis

Article

作者: He, Yajie ; Chen, Dong ; Li, Xiaoyan ; Sun, Bo ; Guo, Wei ; Zhang, Xiaotian ; Nie, Lei ; Zhang, Yinping ; Li, Chen

BACKGROUND:

Melasma shows clinical heterogeneity, but the role of vascular components in treatment resistance remains unclear.

METHODS:

This retrospective cohort study included 75 melasma patients stratified by severity (mild/moderate/severe, n = 25 each) and classified into pure pigmentary (M-type, n = 42) and mixed pigmentary-vascular (M + V-type, n = 33). All received low-fluence Q-switched 1064 nm laser plus oral tranexamic acid. Primary outcome was modified Melasma Area and Severity Index (mMASI) reduction. Multiple regression and interactionanalyses were performed.

RESULTS:

M-type showed significantly higher mMASI reduction than M + V-type (p < 0.001). Treatment resistance rate was markedly higher in M + V-type (p < 0.001). M + V-type, diseaseduration ≥5 years, and severe disease were independent negative predictors. A significantclinical type × severity interaction was detected (p = 0.018), with the M + V effect most pronounced in severe patients.

CONCLUSION:

Mixed pigmentary-vascular type is independently associated with poor response, aggravated by severe disease. For severe M + V-type, adjunctive anti-vascular or anti-inflammatory strategies may be warranted.

447

项与氨甲环酸相关的新闻（医药）

2026-07-23

·皮科Online

盘点汗疱疹的诊疗进展

汗疱疹又称为出汗不良性湿疹，是一种慢性非特异性炎症性的皮肤湿疹样反应，在青壮年中高发。起病较急，多数表现为手掌、手指侧缘、足底及足趾侧缘对称性分布的圆形成簇深在小水疱，可伴瘙痒及灼痛。本病多为季节性发作，夏季症状加重，秋冬季可缓解，但易复发，影响患者的日常工作和生活。本病病因还不明确，可能与精神紧张、吸烟、过敏素质、真菌感染、变应原刺激（最常见的是硫酸镍、重铬酸钾、苯二胺、香料混合物等）、手足多汗、静脉注射免疫球蛋白治疗等有关。本文主要对汗疱疹的诊断和治疗的研究进展作一综述。 Part.1 汗疱疹的诊断诊断以病史和临床表现为主，必要时可进行辅助检查。 01 病史和临床表现详细的病史采集对于疾病诊断十分重要。主要包括以下几点：是否有特应性疾病个人史或家族史；是否接触过过敏原或刺激性物质（最常见的是金属镍、铬、钴、苯二胺、香料混合物等）；是否有真菌感染；是否静脉注射免疫球蛋白；是否使用过IL-17A单抗、霉酚酸酯等；是否有手足多汗症；精神紧张、吸烟是否会使疾病加重。临床表现多为手掌、手指侧缘、足底及足趾侧缘对称分布的米粒大小深在性小水疱，疱液多清亮，偶尔浑浊，水疱干涸后脱皮，常伴瘙痒及灼痛。根据《中国临床皮肤病学》的诊断标准为：季节性发作、对称发生于手掌、损害多为小水疱、干后脱皮等。 02 辅助检查 1.斑贴试验斑贴试验是诊断Ⅳ型超敏反应介导的接触性皮炎的主要方法，是过敏原诊断的金标准。 Vigneshkarthik等的临床研究中发现特应性病史在汗疱疹患者中很常见，镍是最常见的过敏原，斑贴试验可作为汗疱疹诊断的重要工具。 Agarwal、Suman、Majid、Laxmisha、Kishore等人的研究中斑贴试验阳性率从30%-82%不等，《中国临床皮肤病学》认为斑贴试验通常不能帮助诊断，但口服激发试验常能使对某些物质阳性（如镍、秘鲁香膏）的患者皮损增剧。 2.真菌检查可用于排除真菌感染，与水疱型手癣相鉴别。 3.皮肤活检一般不进行皮肤活检。汗疱疹的主要病理表现为表皮海绵形成。 Part.2 鉴别诊断 01 掌跖脓疱病汗疱疹的疱液多清亮，而掌跖脓疱病的疱液多呈黄色；掌跖脓疱病发作没有明显的季节性，病损可以累及指甲。必要时可通过组织病理学检查相鉴别。 02 水疱型手癣初期多累及单侧手，逐渐累及另一只手，除水疱外，也会出现红斑、丘疹。患者常先有足癣后有手癣。真菌检查为阳性。 03 剥脱性角质松解症通常不会出现深在性小水疱，主要表现为表皮角质层松离形成的针头大白点及易剥脱的薄纸样鳞屑。 Part.3 治疗治疗的目标是抑制炎症和水疱形成、止痒、预防或治疗感染。治疗前可通过病史和辅助检查寻找过敏原，避免精神紧张等可能诱发、加重本病的因素。 01 外用药物 1.糖皮质激素糖皮质激素霜剂或软膏是目前治疗汗疱疹的一线外用药物，具有抗炎作用。 Veien等就局部糠酸莫米松治疗慢性手部湿疹的疗效进行了一项开放、随机、前瞻性试验，120例慢性手部湿疹患者（包括38例汗疱疹患者）中有14例患者在初始阶段退出，50例（47%）需要3周、29例（27%）需要6周、27例（25%）需要9周的治疗可控制症状。研究表明糠酸莫米松长期间歇性治疗汗疱疹的效果显著，不良反应轻微，3例患者在治疗开始时出现轻至中度的皮肤萎缩，但这些患者的皮肤萎缩均在研究期间恢复，说明治疗导致的皮肤萎缩可能是可逆的。 2.钙调神经磷酸酶抑制剂钙调神经磷酸酶抑制剂是一种免疫抑制剂，可以抑制T细胞的增殖、分化和多种细胞因子的产生，例如白细胞介素（IL）-2、IL-3、IL-4、肿瘤坏死因子（TNF）和干扰素（INF）-γ。临床上常用于治疗汗疱疹的外用钙调神经磷酸酶抑制剂是他克莫司软膏和吡美莫司乳膏。他克莫司和吡美莫司属于大环内酯类免疫抑制剂，可以抑制细胞因子和炎症介质的释放。 Schnopp等进行了一项随机、观察者单盲的试验，比较了0.1%他克莫司软膏和0.1%糠酸莫米松软膏治疗16例汗疱疹患者的疗效。试验表明他克莫司治疗手部汗疱疹的疗效与糠酸莫米松相当，两种药物治疗2周后DASI均下降约50%。但是与糠酸莫米松相比，他克莫司治疗足部汗疱疹的疗效不佳，可能与足部皮肤角化过度导致他克莫司无法渗透有关，皮肤渗透增强剂、不同的药物剂型或可促进他克莫司渗透。在Belsito等进行的一项随机、双盲、赋形剂对照、为期3周的研究中，294例手部湿疹（包括汗疱疹）的成年患者在使用吡美莫司乳膏治疗22天后相比对照组有很大的改善。 02 系统治疗 1.糖皮质激素系统使用糖皮质激素可用于治疗严重的汗疱疹患者。根据《中国临床皮肤病学》，短期口服泼尼松可迅速起效，一般每天服用30mg，连服5至7天。水疱停止蔓延后剂量逐渐减少，具体用量取决于汗疱疹的严重程度和受累范围。由于不良反应较多，不建议长期大剂量使用糖皮质激素。 2.免疫抑制剂免疫抑制剂可作为中重度或其他治疗无效时的汗疱疹的二线用药。甲氨蝶呤可以抑制二氢叶酸还原酶，从而抑制细胞分裂，具有抗炎的功能。 Egan等对5例常规治疗无效或使用糖皮质激素出现不良反应的重度汗疱疹患者给予每周10-22.5mg的甲氨蝶呤口服治疗，皮损显著改善或消除，不良反应甚微，仅1例出现胃肠道反应。硫唑嘌呤具有嘌呤拮抗的功能，从而抑制淋巴细胞增殖，产生免疫作用。 Scerri等报道的一项回顾性研究中，对6例严重的汗疱疹患者给予硫唑嘌呤治疗，起始剂量为每天100至150mg，维持剂量为每天50至100mg，33.5月后75%的患者疗效显著。硫唑嘌呤的主要缺点是起效缓慢（6-8周）和可能引起罕见的严重骨髓抑制。 Scerri的研究中遇到的不良反应有MCV升高、白细胞减少、肝功能异常和胃肠道反应（恶心、呕吐、腹泻等），停药后恢复正常。 3.生物制剂目前报道的可用于治疗中重度汗疱疹的生物制剂主要是度普利尤单抗。度普利尤单抗可以阻断IL-4和IL-13的信号传导通路，从而抑制IL-4和IL-13介导的炎症反应。 Waldman等应用度普利尤单抗治疗15例中重度汗疱疹患者，平均治疗时间为12.5月，所有患者的红斑和瘙痒症状都明显改善，40%（6/15）的患者皮损完全消除。只有3例患者出现不良反应，1例患者出现结膜炎，2例患者出现面部和颈部发红（dupilumab facial redness，DFR），3例出现不良反应的患者全都继续接受治疗。本研究表明度普利尤单抗治疗汗疱疹的疗效显著且具有良好的安全性和耐受性。 Ogden等报道了一例有6年顽固性汗疱疹病史的40岁女性，每周两次皮下注射25mg TNF-a抑制剂依那西普，6周后皮损完全消退，但4个月后复发，加用一倍剂量无好转。应用依那西普治疗汗疱疹的疗效尚需进一步研究。 4.其他药物 Reis等研究发现奥昔布宁治疗顽固性汗疱疹疗效显著。 Ruzicka等进行了一项大样本随机、多中心、前瞻性、双盲、安慰剂对照试验，将1032例外用糖皮质激素治疗无效的严重慢性手部湿疹患者分为10mg/d阿利维A酸、30mg/d阿利维A酸和安慰剂三组，每天口服一次，治疗24周。该试验包括了377例汗疱疹患者，结果表明30mg/d阿利维A酸组的治疗有效率为33%，10mg/d阿利维A酸组为23%，安慰剂组为16%。 03 光化学疗法具有免疫抑制作用的PUVA或UV-A1对于治疗汗疱疹是有效的。 Schempp等对汗疱疹患者应用水浴PUVA疗法，即在甲氧沙林（8-MOP）药水中局部浸泡15min后用UVA照射的光化学疗法，结果显示93%的汗疱疹患者治疗有效。且水浴PUVA疗法相比外用PUVA疗法的优点是没有光毒性反应。 Tzaneva等研究发现系统PUVA疗法和水浴PUVA疗法治疗汗疱疹的效果相当，但水浴PUVA疗法的耐受性更好。 04 皮内注射A型肉毒杆菌毒素（Btx-A）手足多汗与汗疱疹的发生发展有关，A型肉毒杆菌毒素可以治疗多汗症，通过特异性阻断胆碱能神经末梢释放乙酰胆碱，从而抑制小汗腺的分泌。 Swartling等报道了10例汗疱疹患者一只手单独皮内注射Btx-A，未治疗的另一只手作为对照，7例患者疗效显著。注射后5~6周通过视觉模拟评分法（VAS）评估瘙痒情况，治疗侧平均减轻39%，而未治疗侧平均增加52%。 Swartling等认为这可能与患者对双手瘙痒程度的感知差异有关，因此治疗侧的改善可能导致未治疗侧的VAS评分增加。A型肉毒杆菌毒素治疗的不良反应少，适合用于伴有手足多汗症的汗疱疹患者。 05 3中医治疗张艳等采用薏苡竹叶散内服结合火针外治治疗48例汗疱疹患者，两个疗程（5d为1疗程）后总体有效率为97.92%，且除1例患者无效外，其余病例随访1个月内无复发. 龚霞等将128例汗疱疹患者随机分为两组，两组均口服盐酸左西替利嗪片联合外用糠酸莫米松凝胶对症治疗，在此基础上，治疗组加用除湿外洗1号方浸泡。结果表明，治疗组的总有效率高于对照组，疗效更好，并且治疗组的复发率明显比对照组低。可能与温热中药外洗皮损后，扩张血管，加速血流，促进皮肤吸收外用药物有关。 Part.4 小结综上所述，目前汗疱疹的诊断主要依据病史和临床表现。治疗以局部外用药物为主，严重的汗疱疹患者可采用系统治疗。此外，光化学疗法、A型肉毒杆菌毒素、中医治疗也具有良好的临床疗效。参考文献： [1]王艺璇,晋红中.汗疱疹的诊疗进展[J].皮肤科学通报,2023,40(1):50-54. [2] 任为，王培光，杨森，等.汗疱疹病因和治疗的研究进展[J].中国麻风皮肤病杂志，2008(10):808-810. [3] Bose R,Beecker J.Dyshidrotic eczema in two patients on secukinumab for plaque psoriasis:A case report[J].SAGE Open Med Case Rep,2020,8:2050313X20904561. [4] Semhoun-Ducloux S,Ducloux D,Miguet JP.Mycophenolate mofetil-induced dyshidrotic eczema[J].Ann Intern Med,2000,132(5):417. [5] 赵辨.中国临床皮肤病学[M].江苏科学技术出版社，2017. [6] Vigneshkarthik N,Ganguly S,Kuruvila S.Patch Test as a Diagnostic Tool in Hand Eczema[J].J Clin Diagn Res,2016,10(11):WC04-WC07. [7] Agarwal US,Panse GG.Relevance of patch testing in hand eczema—comment[J].Indian J Dermatol Venereol Leprol,2010,76(1):59-60. [8] Suman M,Reddy BS.Pattern of contact sensitivity in Indian patients with hand eczema[J].J Dermatol,2003,30(9):649-654. [9] Majid I.Contact allergens causing hand eczema in ethnic Kashmiri population:A study of 7-years[J].Indian J Dermatol,2016,61(1):119. [10] 其他略. 推荐阅读化脓性汗腺炎生物制剂及分子靶向治疗研究进展原发性手汗症阶梯化诊疗全方案，皮肤科一线实操指南别只看淡斑效果！氨甲环酸不良反应要注意声明：皮科在线原创内容版权均属皮科在线所有。转载文章或“皮科在线”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场。授权转载时须注明来源。如果存在侵权、或不希望被转载的媒体或个人可与我们联系进行删除处理。

2026-07-23

·北京医学感染与传染研究

生物医学中心 - 医学 24卷 1期（上半年）

BMC Medicine [Jour] AND 24[volume] AND 1[issue]（first half of the year）生物医学中心 - 医学 24卷 1期（上半年） https://link.springer.com/journal/12916/volumes-and-issues/24-1 369 articles in this issue Impact of a real-time automatic quality control system for magnetically controlled capsule gastroscopy: a multicenter randomized controlled trial 磁控胶囊胃镜实时自动质量控制系统的效果：一项多中心随机对照试验 Xiaoya WangDawei ShenZhen Li Research 02 May 2026 Article: 369 Lipid levels and risk-stratified management gaps of dyslipidemia in China 中国血脂水平及血脂异常风险分层管理差距 Long ZhangXu LiuJianping Li Research 02 May 2026 Article: 368 Medicine price and affordability in China and selected ASEAN countries: a cross-country comparison with forward-looking implications for regional pooled procurement 中国与部分东盟国家的药品价格和可负担性：对区域集中采购前瞻性影响的跨国比较 Zhuangqi LiShuting ZhangBao Liu Research 02 May 2026 Article: 367 Dementia risk by metabolic health and obesity in two prospective cohorts 两项前瞻性队列研究中代谢健康和肥胖对痴呆风险的影响 Martin NakashElsa Ojalehto LindforsIda K. Karlsson Research 19 June 2026 Article: 366 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Maternal B-vitamin status modifies the risk of congenital heart disease in offspring associated with prenatal persistent organic pollutants exposure 母体B族维生素状况会改变胎儿在宫内持续暴露于有机污染物时先天性心脏病的患病风险 Sainan LiHai LinLinlin Wang Research 04 May 2026 Article: 365 Obesity-derived metabolites modulate anti-tumor immunity in the tumor microenvironment: from mechanisms to clinical applications 肥胖衍生的代谢产物在肿瘤微环境中调节抗肿瘤免疫：从机制到临床应用 Yihang CaiJunyi JinXiaoying Li Review 06 May 2026 Article: 364 Part of 1 collection:Tumor microenvironment in cancer therapy 所属专题合集：癌症治疗中的肿瘤微环境 Rational use of expensive medicines in the Netherlands: strategies to improve effectiveness and reduce burden on patients and society – a narrative review 荷兰高价药品的合理使用：提高疗效、减轻患者和社会负担的策略——一项叙述性综述 Bart M.F. PenninxSander W. TasCarla E.M. Hollak Review 30 April 2026 Article: 363 NMR-based serum metabolite and lipoprotein profiling for endometriosis across clinically relevant and physiological comparator settings: assessment of diagnostic utility and exploratory biological signals 基于核磁共振（NMR）的血清代谢物和脂蛋白谱分析在子宫内膜异位症的临床相关和生理对照情况中的应用：诊断效用的评估和探索性生物信号的发现 Sisi DengAndré KochChristoph Trautwein Research 17 June 2026 Article: 362 Changes in olfactory function in children and adolescents with obesity following an inpatient weight loss program: a longitudinal study 住院减肥计划后肥胖儿童和青少年嗅觉功能的变化：一项纵向研究 Bea KlosHelene SauerIsabelle Mack Research 17 June 2026 Article: 361 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预及其对健康的影响 The neuroimmune axis in breast cancer: from mechanistic insights to clinical applications 乳腺癌中的神经免疫轴：从机制研究到临床应用 Yimao WuKaiyu ZhangMeng-Yao Li Review 30 April 2026 Article: 360 A biologically informed framework for instrument selection in dietary Mendelian randomization using chemosensory genetics 基于化学感觉遗传学的饮食孟德尔随机化工具选择生物学框架 Liang-Dar HwangCailu LinPaule V. Joseph Research 01 June 2026 Article: 359 Efficacy and safety of cyclosporine plus luspatercept versus cyclosporine in newly diagnosed non-transfusion-dependent non-severe aplastic anemia: A prospective randomized trial 环孢素联合卢帕塞普特与单用环孢素治疗新发非输血依赖型非重型再生障碍性贫血的疗效和安全性：一项前瞻性随机试验 Zhuxin ZhangQinglin HuBing Han Research 29 April 2026 Article: 358 Dietary intake and epigenetic aging in an African population: food groups, dietary patterns, and plant-based diets in the RODAM study 非洲人群的膳食摄入与表观遗传衰老：RODAM研究中的食物组、膳食模式与植物性饮食 Naomi C.S. AuwerdaMuhau. M. MungambaFelix P. Chilunga Research 28 April 2026 Article: 357 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Mitoxantrone hydrochloride liposome (Lipo-MIT) combined with capecitabine in HER2-negative advanced breast cancer: a dose-escalation, phase I study 米托蒽醌盐酸盐脂质体（Lipo-MIT）联合卡培他滨治疗HER2阴性晚期乳腺癌：一项剂量递增Ⅰ期研究 Jiaxuan LiuMingxia JiangQiao Li Research 28 April 2026 Article: 356 Familial healthy aging and longevity: the role of spouses 家族健康衰老与长寿：配偶的作用 Søren NetraAngéline GalvinKaare Christensen Research 28 April 2026 Article: 355 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Peripheral blood biomarkers RCAN1, Clusterin, RAGE, and malondialdehyde for early diagnosis and progression of Alzheimer’s disease 外周血生物标志物RCAN1、Clusterin、RAGE和丙二醛用于阿尔茨海默病的早期诊断与进展监测 Aurora Román-DomínguezCristina Mas-BarguesJosé Viña Research 27 April 2026 Article: 354 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Palliative care for the people without medical insurance in Germany: an empirical ethical approach 德国无医疗保险人群的姑息治疗：一种实证伦理方法 Matthias ZimmerAntonia Sahm Research 11 June 2026 Article: 353 Part of 1 collection:Palliative care and medicine 所属专题合集：姑息治疗与姑息医学 Maternal factors associate with microbiota-derived extracellular vesicle profiles in pregnancy: a clinical cohort study 妊娠期母体因素与微生物衍生的细胞外囊泡特征的相关性：一项临床队列研究 Jenni TurunenKaisu KyröTerhi Ruuska-Loewald Research 28 May 2026 Article: 352 Prenatal computed tomography (CT) and risk of congenital heart disease and cerebral palsy: A nationwide mother–child paired cohort study 产前计算机断层扫描（CT）与先天性心脏病及脑瘫风险：一项全国性母子配对队列研究 Tae Wook KangJihye HeoDanbee Kang Research 27 April 2026 Article: 351 Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease 治疗性TG2抑制可逆转乳糜泻的系统性多组学失调 Valeriia DotsenkoHana Hien Leon behalf of the CEC-3 Investigators Research 24 April 2026 Article: 350 Adulthood stressful life events as predictors of incident cardiovascular disease: insights from two prospective cohorts 成年期应激性生活事件作为心血管疾病新发预测因子：来自两项前瞻性队列的见解 Shuang WuSiqi LyuGregory Y. H. Lip Research 24 April 2026 Article: 349 Camrelizumab plus apatinib for immune checkpoint inhibitor-naive patients with metastatic clear cell renal cell carcinoma after first-line tyrosine kinase inhibitor treatment failure: a single-arm phase 2 trial 卡瑞利珠单抗联合阿帕替尼用于免疫检查点抑制剂初治转移性透明细胞肾细胞癌一线酪氨酸激酶抑制剂治疗失败后：一项单臂Ⅱ期试验 Xiuyu CaiXia ZhengPei Dong Research 24 April 2026 Article: 348 Introducing the need for a consensus-based framework for protocol modifications to improve trial trustworthiness 提出建立基于共识的方案修改框架以提升临床试验可信度的必要性 Cora BurgwinkelManon GicquelClara Locher Debate 24 April 2026 Article: 347 Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies 中国女性人群HPV流行动力学建模及宫颈癌消除策略优化 Yuwei LiYi-Fan LinJianxin Zhen Research 22 April 2026 Article: 346 Multiparameter concept-based interpretable model for early breast cancer diagnosis and structured reporting: a multi-center, multi-reader, radiologist-in-the-loop study 基于多参数概念的可解释模型用于早期乳腺癌诊断与结构化报告：一项多中心、多读者、放射科医师参与的研究 Jiao QuYang LiuSu Lui Research 23 April 2026 Article: 345 Blood-based DNA methylation marker model for short-term and long-term lung cancer risk prediction 基于血液DNA甲基化标志物模型的肺癌短期与长期风险预测 Megha BhardwajYi-Qian SunHermann Brenner Research 06 June 2026 Article: 344 Integrated serum proteomic and liver genomic analyses identify molecular signatures associated with metabolic dysfunction-associated steatotic liver disease: a multi-cohort study 整合血清蛋白质组学与肝脏基因组学分析鉴定与代谢功能障碍相关脂肪性肝病相关的分子特征：一项多队列研究 Jinjian XuWanglong GouYu-ming Chen Research 17 April 2026 Article: 343 Predicting amyotrophic lateral sclerosis stage based on multi-parameter ultrasound: development and validation of an interpretable machine learning model 基于多参数超声预测肌萎缩侧索硬化症分期：可解释机器学习模型的构建与验证 Tianhua YangYing WangGaoyi Yang Research 22 April 2026 Article: 342 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与更新 Duration of anti-seizure medicines started for acute symptomatic seizures due to acute meningitis: a systematic review and meta-analysis 急性脑膜炎所致急性症状性发作的抗癫痫药物起始疗程：一项系统综述与荟萃分析 Manya PrasadAmit KumarTarun Dua Research 22 April 2026 Article: 341 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述集 Prenatal exposure to flood and risk of low birth weight: a multi-country study from 36 African countries 产前遭遇洪水与低出生体重风险：来自36个非洲国家的多国研究 Qian LiQian LiFengchao Liang Research 21 April 2026 Article: 340 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Sunshine duration and episodes of mental disorders and the inverse effect modification by ambient temperature 日照时长与精神障碍发作及环境温度的逆效应修饰 Lijun BaiJuan ChenShaowei Wu Research 21 April 2026 Article: 339 The role of continuous glucose monitoring for diagnosis of gestational diabetes: exploring the potential 持续葡萄糖监测在妊娠糖尿病诊断中的作用：潜力探索 M. CrowleyC. NewmanF. P. Dunne Review 21 April 2026 Article: 338 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠糖尿病的诊断与治疗 Pre-diagnostic biomarkers and risk of stress-related disorders: a cohort study based on electronic health records 应激相关障碍诊断前生物标志物与风险：一项基于电子健康记录的队列 Anna A. PeltolaEsha KhanJake Lin Research 01 June 2026 Article: 337 Epigenome-wide analysis of DNA-methylation signatures following climate-related disasters 气候相关灾害后DNA甲基化信号的全表观基因组分析 Wenzhong HuangRongbin XuYuming Guo Research 20 April 2026 Article: 336 Part of 1 collection:Climate change and human health 所属专题合集：其后变化与人类健康 Redeemed prescription medicines to measure quality of life of patients with long-term conditions: a national cross-sectional study 通过已兑换的处方药衡量慢性病患者生活质量：一项全国性横断面研究 Henrik Hedegaard Pliess LarsenVolkert SiersmaAnne Holm Research 20 April 2026 Article: 335 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 属于专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Viral shedding dynamics in coxsackievirus A6 hand, foot, and mouth disease: a prospective, individual-level analysis 柯萨奇病毒A6型手足口病的病毒排毒动态：一项前瞻性个体水平分析 Jiale MengYue ChengLu Long Research 18 April 2026 Article: 334 Mental health and wellbeing interventions for uniformed service personnel: a mixed methods systematic review 军警人员心理健康与福祉干预措施：一项混合方法系统综述 Jessica EatonHolly EllardAlan Simpson Research 17 April 2026 Article: 333 WISE-Therapy (What’s Important: Schedule and Engage) and bouldering psychotherapy for depression: A randomized clinical trial WISE-Therapy（智慧疗法）（重要之事：安排与参与）与抱石心理治疗用于抑郁症：一项随机临床试验 Johannes KornhuberPiotr LewczukKatharina Luttenberger Research 27 May 2026 Article: 332 Handgrip weakness is associated with motor cortex atrophy in rheumatoid arthritis: a cross-sectional study with a hand exercise intervention 握力减弱与类风湿关节炎患者运动皮层萎缩相关：一项包含手部运动干预的横断面研究 Amanda L GustafssonRolf A HeckemannCaroline Wasén Research 26 May 2026 Article: 331 Interpretable multimodal PET/CT-EHR fusion via mixture-of-experts for prognostic stratification in mantle cell lymphoma: a multicenter study 基于专家混合模型的可解释性多模态PET/CT-HER（电子健康记录）融合在套细胞淋巴瘤预后分层中的应用：一项多中心研究 Chong JiangZitong ZhangRong Tian Research 16 April 2026 Article: 330 Non-invasive diagnosis strategy integrating PSMA PET/CT and mpMRI for patients with suspected prostate cancer: a multi-center study 整合PSMA PET/CT与多参数MRI的无创诊断策略用于疑似前列腺癌患者：一项多中心研究 Yuhang WangYongxiang TangYi Cai Research 16 April 2026 Article: 329 Clinical benefit of tenecteplase despite failed recanalization in late-window ischemic stroke: a post hoc analysis of the TRACE-3 trial 晚期窗口缺血性卒中中即使再通失败，替奈普酶仍具临床获益：TRACE-3试验的事后分析 Zhengzhao LuZiran WangYongjun Wang Research 16 April 2026 Article: 328 Infant subcortical brain volumes associated with maternal obesity and diabetes: a large multicohort human study 婴儿皮层下脑容量与母亲肥胖及糖尿病相关：一项大型多队列人类研究 Ann M. AlexJerod M. RasmussenENIGMA-ORIGINs working group Research 16 April 2026 Article: 327 Cost-effectiveness of prehabilitation for elderly (pre-)frail patients prior to elective surgery compared to standard care - an economic evaluation from a societal perspective 择期手术前老年（衰弱前期/）衰弱患者预康复与标准护理的成本效益比较——一项基于社会视角的经济学评估 Tanja RombeyHelene EckhardtLukas Schöner Research 21 May 2026 Article: 326 Frozen melanoma tissues yield extracellular vesicles with preserved diagnostic and immunogenic properties 冷冻黑色素瘤组织可获得具有保存完好的诊断和免疫特性的细胞外囊泡 Daniele D´ArrigoKyong-Su ParkRossella Crescitelli Research 21 May 2026 Article: 325 Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children 儿童mRNA疫苗接种所引发的分层防御免疫动力学的潜在机制 Yiyu LiaoHoong Kai ChuaKeisuke Ejima Research 15 April 2026 Article: 324 Epigenetic aging markers in the association between frailty and mortality among U.S. adults 美国成年人虚弱与死亡率相关性中的表观遗传衰老标志物 May A. BeydounNicole Noren HootenAlan B. Zonderman Research 15 April 2026 Article: 323 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Evolution with age of the relationship between sex and post-COVID symptoms: a population-based cohort study 性别与新冠后遗症症状关系随年龄的演变：一项基于人群的队列研究 Anne PastorelloCécile Vuillermozfor the EpiCov study group Research 14 April 2026 Article: 322 Bowel cancer care in individuals with an intellectual disability: a population-based cohort study of symptoms, diagnostic pathways, treatment and survival 智力障碍个体的肠癌护理：症状、诊断路径、治疗及生存的基于人群的队列研究 Oliver John KennedyUmesh ChauhanDarren Mark Ashcroft Research 20 May 2026 Article: 321 Association of antiviral use for influenza among non-severe cases with subsequent hospitalization and mortality 非重症流感病例使用抗病毒药物与后续住院及死亡的关系 Taito KitanoShinya TsuzukiSayaka Yoshida Research 06 April 2026 Article: 320 Social and digital engagement associated with reduced depressive symptoms in adults aged 50 and older: a multi-country cohort study 社交及数字互动与50岁及以上成年人抑郁症状减少的关系：一项多国队列研究 Yaping WangLiyuan TaoJue Liu Research 07 April 2026 Article: 319 Fat-soluble vitamin deficiency in children with neurodevelopmental disorders: a cross-sectional study 神经发育障碍儿童脂溶性维生素缺乏：一项横断面研究 Jingjing RaoXiaomei WangChangzhen Li Research 08 April 2026 Article: 318 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Skeletal and cardiac muscle longitudinal associations in the Baltimore Longitudinal Study of Aging (BLSA) 巴尔的摩老龄化纵向研究（BLSA）中骨骼肌与心肌的纵向关联 Jie Jun WongFei GaoAngela S. Koh Research 06 April 2026 Article: 317 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学与风险因素的作用 Early repetitive transcranial magnetic stimulation for preventing chronic postoperative pain in older adults: a randomized clinical sub-study 早期重复经颅磁刺激预防老年患者慢性术后疼痛：一项随机临床子研究 Wei-Wei ZhouZhi YangChao-Chao Zhong Research 06 April 2026 Article: 316 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能障碍中的神经调控 Clinical epidemiology and risk prediction of unsuccessful treatment outcomes in pulmonary tuberculosis with diabetes mellitus 合并糖尿病的肺结核治疗失败结局的临床流行病学与风险预测 Ping LiFeilong LuJunjun Jiang Research 25 March 2026 Article: 315 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Spatiotemporal patterns of climate-sensitive vector-borne diseases in Bangladesh: leveraging machine learning and spatial regression for intervention strategies 孟加拉国气候敏感型虫媒传染病的时空格局：利用机器学习与空间回归制定干预策略 Md. Siddikur RahmanMd. Abu Bokkor ShiddikArman Hossain Chowdhury Research 13 April 2026 Article: 314 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 The association of pregnancy complications/risk factors with the development of cancer in women: an umbrella review 妊娠并发症/危险因素与女性癌症发生的关系：一项伞状综述 Jemma HealeyMegha SinghMairead Black Research 13 April 2026 Article: 313 Synergistic effects of obesity and type 2 diabetes on adiposity-related cancer risk across age strata 肥胖与2型糖尿病对不同年龄层肥胖相关癌症风险的协同效应 Alex E. HenneyMegan HeagueDaniel J. Cuthbertson Research 13 April 2026 Article: 312 Acute COVID-19 severity and impaired cognitive function up to 32months after diagnosis: an observational study 急性新冠严重程度与确诊后长达32个月的认知功能损害：一项观察性研究 Ingibjörg MagnúsdóttirAnders B. NygaardUnnur Anna Valdimarsdóttir Research 11 April 2026 Article: 311 Maternal macronutrient intake and gestational diabetes: systematic review of prospective observational studies and dose-response meta-analyses 孕产妇宏量营养素摄入与妊娠期糖尿病：前瞻性观察研究的系统综述及剂量反应荟萃分析 Cameron D. YoungMichael G. GarrattAndrew N. Reynolds Research 11 April 2026 Article: 310 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与管理 Global, regional, and national burden of colorectal cancer attributable to central obesity: a population attributable fraction analysis 中心性肥胖所致结直肠癌的全球、区域及国家负担：人群归因分数分析 Daniele PiovaniGisella FiglioliStefanos Bonovas Research 10 April 2026 Article: 309 Evaluating DNA methylation markers and extended HPV genotyping in first-void urine for detecting high-grade cervical lesions in HPV-positive women: a cross-sectional study 评估首段尿液中DNA甲基化标志物及扩展型HPV基因分型在HPV阳性女性中检测高级别宫颈病变的价值：一项横断面研究 Mette TranbergSeverien Van KeerRenske Steenbergen Research 10 April 2026 Article: 308 Targeted long-read genomic and epigenomic profiling enhances timely comprehensive variant discovery in hypotonia and muscle weakness 靶向长读长基因组与表观基因组测序提升低张力与肌无力的全面变异及时发现 Eman AbuijlanShruti SinhaAhmad Abou Tayoun Research 08 April 2026 Article: 307 Targeting immunosenescence in lung diseases: mechanistic insights and clinical interventions 靶向肺疾病中的免疫衰老：机制洞察与临床干预 Yin ZhangXianzhe YuFengming Luo Review 08 April 2026 Article: 306 Apolipoprotein C3 drives adverse cardiac remodeling in ischemic heart failure 载脂蛋白C3促进缺血性心力衰竭中的不良心脏重塑 Yufei HanYixue ZhaoXunde Xian Research 09 April 2026 Article: 305 Part of 1 collection:Cardiac immunity and inflammation 所属专题合集：心脏免疫与炎症 Causal modeling of school aversion in psychiatrically referred adolescents: a DoWhy-based analysis 转诊精神病科的青少年厌学情绪的因果模型：基于DoWhy的分析 Mengmeng ZhangXin MaMeijuan Wang Research 09 April 2026 Article: 304 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Aperiodic and periodic neural activity during sleep in autism spectrum disorders 自闭症谱系障碍睡眠中的非周期性和周期性神经活动 Noemi MazzoniEva-Maria KurzAndrea Caria Research 18 March 2026 Article: 303 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Association and mediating pathways between intergenerational educational mobility and depressive symptoms: findings from high- and middle-income countries 代际教育流动性与抑郁症状之间的关联及中介路径：来自高收入和中等收入国家的发现 Yingchao ZengSimu HuangChihua Li Research 02 April 2026 Article: 302 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Scoping review on the prioritisation of high-consequence infectious pathogens for research preparedness and response to health emergencies 关于优先研究高后果性感染病原体以应对突发卫生事件的研究准备与响应的范围综述 Nicolas PulikHolly SadlerAlice Norton Research 01 April 2026 Article: 301 Serum uric acid levels among children and adolescents in China: percentile reference values and national prevalence estimates of hyperuricemia 中国儿童和青少年血清尿酸水平：高尿酸血症的百分位参考值和全国患病率估计 Qianrang ZhuXin’nan ZongMin Zhao Research 31 March 2026 Article: 300 Waist circumference and grip strength and their joint relations to type 2 diabetes incidence in UK Biobank 腰围和握力及其与英国生物银行中2型糖尿病发病风险的联合关系 Johanna WirlerMichael J. SteinMichael F. Leitzmann Research 07 May 2026 Article: 299 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Targeting cardiomyocyte-derived extracellular vesicle miR-574-5p protects against cognitive impairment induced by ischemia–reperfusion 靶向心肌细胞衍生的外泌体miR-574-5p可预防缺血再灌注引起的认知障碍 Erya ChenXiaoyu ZhuChan Chen Research 19 March 2026 Article: 298 Motor-related reorganization in left inferior frontal gyrus after subcortical stroke: neurochemical basis and response to targeted neuromodulation 皮层下卒中后左侧额下回的运动相关重组：神经化学基础及靶向神经调控的反应 Wenjun HongYaxi WangZhiyong Zhao Research 27 March 2026 Article: 297 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能疾病中的神经调控 Association between ambient temperature and childhood vaccination coverage in low- and middle-income countries 中低收入国家环境温度与儿童疫苗接种覆盖率之间的关联 Hongqiu ZhengYixiang ZhuZhiyuan Hou Research 11 March 2026 Article: 296 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 White matter changes in reward circuits of amyotrophic lateral sclerosis: a fixel-based study of appetite loss 肌萎缩侧索硬化症奖赏回路白质改变：基于纤维束的食欲减退研究 Jeryn ChangHarry LipscombeThomas B. Shaw Research 27 March 2026 Article: 295 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 The adverse effects associated with tirzepatide use in patients at increased risk of cardiovascular events: a systematic review with meta-analysis and Trial Sequential Analysis 替西帕肽在心血管事件风险增加患者中的不良反应：一项系统综述与荟萃分析及试验序贯分析 Christina Dam Bjerregaard SillassenPascal FaltermeierJanus Christian Jakobsen Research 27 March 2026 Article: 294 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其健康影响 Age-related genomic characterization and therapeutic targets in Chinese breast cancer: insights from prospective targeted sequencing and clinical data analysis 中国乳腺癌年龄相关基因组特征及治疗靶点：前瞻性靶向测序与临床数据分析的见解 Xin-Yi SuiXiao-Qing SongLei Fan Research 27 March 2026 Article: 293 Impact of the family cohesion-centered frailty intervention on older gastric cancer patients: a non-randomized controlled trial 以家庭凝聚力为中心的衰弱干预对老年胃癌患者的影响：一项非随机对照试验 Yinning GuoYimeng ChenQin Xu Research 27 March 2026 Article: 292 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症临床试验 Perceptions of HPV vaccination: a qualitative study with adolescents, parents, school staff, and pharmacists 对HPV疫苗接种的看法：一项针对青少年、家长、学校工作人员和药剂师的定性研究 Laurène HoutinLucia RomoClémence Brun Research 26 March 2026 Article: 291 Risk classification of internet gaming disorder based on neurobiological subtyping from impulsivity-linked resting-state functional connectivity: a longitudinal design study 基于冲动性相关静息态功能连接神经生物学亚型的网络游戏障碍风险分类：一项纵向设计研究 Xinwen WenJiahao ZhaoKai Yuan Research 26 March 2026 Article: 290 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Trainee-delivered school-based intervention with guided narrative writing for adolescent anxiety and depression: a cluster randomized controlled trial 由受训者实施的、基于学校的、以引导性叙事写作为干预手段的青少年焦虑和抑郁干预：一项整群随机对照试验 Yixuan WangMuyang LiYinyin Zang Research 26 March 2026 Article: 289 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Nourishing future generations: the critical role of healthy school lunches and strategic food procurement 滋养未来一代：健康学校午餐和战略性食品采购的关键作用 Aurora Perez-CornagoCarmen Piernas Comment 05 May 2026 Article: 288 Multi-omics analysis reveals sex-specific etiology of human muscle weakness following musculoskeletal injury 多组学分析揭示人类骨骼肌损伤后肌无力的性别特异性病因 Alexander R. KeebleAllison M. OwenChristopher S. Fry Research 26 March 2026 Article: 287 Public health impact of catch-up vaccination or additional booster doses with pre-erythrocytic malaria vaccine R21/Matrix-M: a modelling study 使用红细胞前期疟疾疫苗R21/Matrix-M进行追赶接种或额外加强接种的公共卫生影响：一项建模研究 Kelly McCainHillary M. TopazianAzra C. Ghani Research 25 March 2026 Article: 286 A digital-health multidomain lifestyle management framework and its associations with cardiometabolic health: a real-world observational study 数字健康多领域生活方式管理框架及其与心脏代谢健康的关联：一项现实观察性研究 Han XiaoKexin DingDafang Chen Research 25 March 2026 Article: 285 Bilateral sequential accelerated theta-burst stimulation for treatment-resistant depression: an open-label randomized controlled trial 双侧序贯加速θ波爆发刺激治疗难治性抑郁症：一项开放标签随机对照试验 Xingxing LiEnze TangDongsheng Zhou Research 25 March 2026 Article: 284 Part of 1 collection:Neuromodulation in brain functional disorders 所属专题合集：脑功能疾病中的神经调控 Digenic inheritance of mutations in SPG7 and AFG3L2 causes motor neuron and cerebellar disorders SPG7和AFG3L2基因突变双基因遗传导致运动神经元和小脑疾病 Mehrdad A. EstiarEric YuZiv Gan-Or Research 24 March 2026 Article: 283 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新颖动态 Social isolation and 59 common health conditions: insights from observational and genetics analyses 社交孤立与59种常见健康状况：观察性研究与遗传学分析的见解 Sizhi AiQiqi WuYannis Yan Liang Research 23 March 2026 Article: 282 Clustering depression subgroups based on dorsolateral prefrontal-subgenual anterior cingulate cortex peak functional connectivity reveals different symptom profiles and TMS treatment outcomes 基于背外侧前额叶-膝下前扣带回皮层峰值功能连接性的抑郁亚组聚类分析揭示了不同的症状特征和经颅磁刺激（TMS）治疗结果 Gai KongSirui WangYingying Tang Research 23 March 2026 Article: 281 Robust human genetic evidence supporting causal effects of FGF21 on reducing alcohol consuming behaviours 人类遗传学有力证据支持成纤维细胞生长因子21（FGF21）对减少饮酒行为的因果效应 Héléne T. CronjéSile HuDipender Gill Research 23 March 2026 Article: 280 Artificial intelligence-based prediction of fetal hypoxia: a multicenter model development and nationwide AI-human comparison 基于人工智能的胎儿缺氧预测：多中心模型开发及全国范围的人工智能与人类对比 Suiwen LinXiaodan DiBin Liu Research 21 March 2026 Article: 279 Efficacy and long-term engagement of a WeChat-integrated modality versus a traditional quitline on smoking cessation in China: a randomised controlled trial 微信整合模式与传统戒烟热线在中国戒烟中的疗效及长期参与度：一项随机对照试验 Shuilian ChuDi ZhangLirong Liang Research 21 March 2026 Article: 278 A culturally-safe primary care intervention for migrant/refugee women suffering domestic violence and abuse: HARMONY—a pragmatic cluster randomised controlled trial 针对遭受家庭暴力和虐待的移民/难民妇女的文化安全初级护理干预措施：HARMONY——一项实用性整群随机对照试验 Angela J. TaftFelicity YoungGene Feder Research 21 March 2026 Article: 277 Development, integration, retention, and career progression of physician associates/assistants in UK NHS hospitals and clinical teams: a multiple-case qualitative study 英国国家医疗服务体系（NHS）医院及临床团队中医师助理/协理医师的发展、整合、留任及职业晋升：一项多案例定性研究 Yingxi ZhaoRhys SwainstonThe ROADMAP-PA collaborator group Research 20 April 2026 Article: 276 Compound climate extreme events and associated health impacts: a scoping review 复合气候极端事件及其相关健康影响：一项范围性综述 Shifali MathewsCaitlin WalkerJaime Madrigano Research 20 March 2026 Article: 275 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Smoking history, eligibility for lung cancer screening and risk of death by lung cancer or other causes -- a longitudinal, time-variable analysis of the EPIC-Heidelberg cohort 吸烟史、肺癌筛查资格以及死于肺癌或其他原因的风险——对EPIC-海德堡队列的纵向、时变分析 Yue ChenSrimanti DuttaRudolf Kaaks Research 28 April 2026 Article: 274 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Cortical functional hierarchy disruption following subcortical stroke 皮质功能层级在皮层下卒中后的破坏 Ke WuGang LiuGaolang Gong Research 19 March 2026 Article: 273 Characterizing the effects of genetic liability to autoimmune conditions on pregnancy outcomes using Mendelian randomization 利用孟德尔随机化方法表征遗传易感性对自身免疫性疾病患者妊娠结局的影响 Elisabeth AitonNancy S. McBrideMaria Carolina Borges Research 19 March 2026 Article: 272 Dystrophin-gene mutation location influences severity of electroretinogram defects in mouse models of Duchenne muscular dystrophy 杜氏肌营养不良症小鼠模型中，肌营养不良蛋白基因突变位置对视网膜电图缺陷严重程度的影响 André Maurício Passos LiberMirella BarboniCyrille Vaillend Research 25 April 2026 Article: 271 Personalizing the treatment of head and neck cancer in vitro: The 3D-OTC model 体外个性化治疗头颈部肿瘤：三维器官芯片（3D-OTC）模型 Fabian StögbauerTobias WeiserBarbara Wollenberg Research 25 April 2026 Article: 270 Part of 1 collection:Organoids: connecting molecular insights and clinical practice 所属专题合集：类器官：连接分子见解与临床实践 Risk factor profiles for infections in individuals with type 2 diabetes: a prospective cohort study 2型糖尿病患者感染的风险因素特征：一项前瞻性队列研究 Han-Cheng YuJi-Juan ZhangYun-Fei Liao Research 18 March 2026 Article: 269 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Cause-specific years of life lost attributable to non-optimal body mass index by county, sex, race, and ethnicity in the USA, 2000–2019: a systematic analysis of health disparities 2000-2019年美国按县、性别、种族和民族划分的非最佳体重指数导致的特定原因寿命损失年数：一项关于健康差异的系统分析 GBD US Health Disparities CollaboratorsFarah MouhannaLaura Dwyer-Lindgren Research 18 March 2026 Article: 268 Global and regional prevalence, burden, and risk factors for MASLD in children and adolescents aged 5 to 24years: a systematic review, meta-analysis, and modeling study 全球和区域5至24岁儿童和青少年代谢相关脂肪性肝病（MASLD）的患病率、负担及风险因素：一项系统综述、荟萃分析和建模研究 Yunfei LiuShan CaiSusan M. Sawyer Research 18 March 2026 Article: 267 Relative leukocyte telomere length and the risk of lung cancer progression in individuals with pulmonary nodules 相对白细胞端粒长度与肺结节患者肺癌进展风险的关系 Yuanyuan WuDong SunFeifei Cheng Research 18 March 2026 Article: 266 Effects of Tai Chi combined with transcranial direct current stimulation on pain in knee osteoarthritis: a randomized controlled neuroimaging trial 太极拳结合经颅直流电刺激对膝骨关节炎疼痛的影响：一项随机对照神经影像学试验 Xuefeng LiuTong TangJing Tao Research 17 March 2026 Article: 265 DNA hypermethylation of choline kinases drives blockage of choline-phosphatidylcholine biosynthesis: lipidomic biomarkers and epigenetic insights of hepatic steatosis induced by arsenic 胆碱激酶DNA高甲基化驱动胆碱-磷脂酰胆碱生物合成受阻：砷诱导的肝脂肪变性的脂质组学生物标志物及表观遗传学见解 Qiwen FuQi WangLu Ma Research 17 March 2026 Article: 264 Dynamics of Mpox epidemics by the interplay of COVID-19 pandemic in Africa 非洲猴痘（Mpox）流行与新冠肺炎（COVID-19）大流行相互作用下的猴痘流行病学动态 Oyewole K. OyedeleNifarta P. AndrewAlash’le Abimiku Research 17 March 2026 Article: 263 Part of 1 collection:Mpox: Epidemiology, prevention, and treatment 所属专题合集：猴痘：流行病学、预防和治疗 SPP1high fibrogenic macrophages mediate protective fibrotic remodeling and promote vascular stability in hypertension-associated aortic dissection SPP1高表达成纤维性巨噬细胞介导保护性纤维化重塑并促进高血压相关主动脉夹层的血管稳定性 Shuai ZhaoXiumeng HuaJiangping Song Research 16 March 2026 Article: 262 Longitudinal associations between body fat mass and cardiovascular outcomes among Chinese children: mediation by cardiometabolic risk factors 中国儿童身体脂肪量与心血管结局之间的纵向关联：通过心脏代谢风险因素的中介作用 Hui YangQin LiuBo Xi Research 16 March 2026 Article: 261 The timing of the commencement of pulmonary rehabilitation in hospitalized patients with acute exacerbation of COPD: a systematic review and network meta-analysis 住院慢性阻塞性肺疾病急性加重患者开始肺康复治疗的时机：一项系统综述和网络荟萃分析 Peilin JiaHailong ZhangLongyu Wang Research 16 March 2026 Article: 260 Correction: Vegetable intake and the risk of bladder cancer in the BLadder Cancer Epidemiology and Nutritional Determinants (BLEND) international study 更正：膀胱癌流行病学和营养决定因素（BLEND）国际研究中蔬菜摄入量与膀胱癌风险的关系 Evan Yi-Wen YuAnke WesseliusMaurice P. Zeegers Correction 22 April 2026 Article: 259 Comparative efficacy of neoadjuvant short-course versus long-course radiotherapy-based regimens with or without immunotherapy for locally advanced pMMR rectal cancer: a systematic review and network meta-analysis 基于放疗的新辅助短疗程与长疗程治疗方案（联合或不联合免疫治疗）对局部晚期错配修复功能正常（pMMR）型直肠癌的疗效比较：一项系统综述与网状荟萃分析 Liqing LiXiaoyao MengTingshi Su Research 14 March 2026 Article: 258 Association between bariatric surgery and long-term ability to perform household tasks in the Swedish Obese Subjects study: a controlled prospective cohort study 瑞典肥胖受试者研究：减肥手术与长期从事家务能力之间的关联——一项对照前瞻性队列研究 Petra BrembeckJohanna C. Andersson-AssarssonPer-Arne Svensson Research 18 April 2026 Article: 257 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 The role of male foetal sex on maternal and neonatal outcomes in pregnancies complicated by gestational diabetes—secondary analysis of a randomised placebo controlled clinical trial of metformin in gestational diabetes (EMERGE) 男性胎儿性别对妊娠期糖尿病合并妊娠的母婴预后的影响——妊娠期糖尿病二甲双胍随机对照安慰剂临床试验（EMERGE）的二次分析 Christine NewmanAlberto Alvarez-IglesiasFidelma Dunne Research 12 March 2026 Article: 256 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与管理 Downregulated lysyl oxidase in plasma extracellular vesicles: a biomarker linked to brain metastasis risk in lung adenocarcinoma 血浆细胞外囊泡中赖氨酰氧化酶表达下调：与肺腺癌脑转移风险相关的生物标志物 Jing LiYu PeiYi Liu Research 12 March 2026 Article: 255 The influence of age-dependent susceptibility on RSV transmission dynamics and immunisation population-level impact 年龄依赖性易感性对呼吸道合胞病毒（RSV）传播动力学及免疫接种人群层面影响的研究 Chenkai ZhaoYuhe ZhangHarish Nair Research 11 March 2026 Article: 254 A human-derived Bacteroides strain attenuates depressive-like behavior in a rat model of social defeat-induced stress 一株人源拟杆菌属菌株可减轻社会挫败诱导应激大鼠模型的抑郁样行为 Marisol I. DothardMariaelena CaboniPhilip Strandwitz Research 10 March 2026 Article: 253 Adverse events in both childhood and adulthood are associated with molecular, clinical and functional markers of ageing 童年和成年期的不良事件均与衰老的分子、临床和功能标志物相关 Monica AasThole H HoppenJulian Mutz Research 28 April 2026 Article: 252 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Genetic predisposition to high BMI, ultra-processed food consumptions in childhood, and adiposity in young adulthood: a 17-year prospective cohort study of 3061 individuals 高BMI遗传易感性、儿童期超加工食品摄入与成年早期肥胖：一项对3061例个体进行的为期17年的前瞻性队列研究 Ziyi ZhouQiaosen ChenFrederick K. Ho Research 16 April 2026 Article: 251 Enhanced predictive performance of artificial intelligence in individualized ovarian stimulation of in vitro fertilization: a retrospective cohort study 人工智能在体外受精个体化卵巢刺激中的预测性能提升：一项回顾性队列研究 Guiquan WangMinyue TangYimin Zhu Research 10 March 2026 Article: 250 PCDSOS: a novel clinical predictive tool for screening primary ciliary dyskinesia in adult bronchiectasis patients—a multicenter derivation and external validation study PCDSOS：一种用于筛查成人支气管扩张症患者原发性纤毛运动障碍的新型临床预测工具——一项多中心推导及外部验证研究 Wangji ZhouLin WangXinlun Tian Research 10 March 2026 Article: 249 Detection rate and mutational landscape in extracranial arteriovenous malformations: a cohort study 颅外动静脉畸形的检出率及突变谱：一项队列研究 Vanessa F. SchmidtDenny Schanzefor the APOLLON Investigators Research 16 April 2026 Article: 248 Kinetics of antibodies and risk of respiratory syncytial virus infection: a longitudinal cohort in Taizhou City, eastern China 抗体动力学与呼吸道合胞病毒感染风险：中国东部台州市的一项纵向队列研究 Qiang WangDavid HodgsonWeibing Wang Research 09 March 2026 Article: 247 Cell therapy strategies for organ regeneration 器官再生的细胞治疗策略 L. PapamichailL. J. W. van der LaanM. J. Hoogduijn Review 25 February 2026 Article: 246 Transcutaneous spinal cord stimulation combined with robot-assisted gait training to improve mobility and balance in spinal cord injury: intramuscular electromyography as a biomarker for functional recovery 经皮脊髓电刺激联合机器人辅助步态训练改善脊髓损伤患者的行动能力和平衡能力：肌内肌电图作为功能恢复的生物标志物 Abdul RashadHe XijingMuhammad Asif Registered Report 09 March 2026 Article: 245 Neoadjuvant camrelizumab combined with radiotherapy as a chemotherapy-sparing approach for resectable locally advanced esophageal squamous cell carcinoma: a phase II clinical trial (ESOCORT-NIRT) 新辅助卡瑞利珠单抗联合放疗作为可切除局部晚期食管鳞癌的免化疗方案：一项II期临床试验（ESOCORT-NIRT） Maohui ChenYizhou HuangBin Zheng Research 09 March 2026 Article: 244 FLASH radiotherapy preserves systemic and tissue homeostasis while maintaining antitumor efficacy FLASH放疗在保持抗肿瘤疗效的同时维持全身及组织稳态 Giulia FuriniEduarda Mota da SilvaMargherita Maffei Research 26 February 2026 Article: 243 fMRI-guided V1-targeted rTMS improves depressive symptoms in adolescents and young adults with bipolar disorder: a double-blind randomized controlled trial 功能磁共振成像引导的V1区靶向重复经颅磁刺激改善青少年及青年双相情感障碍患者的抑郁症状：一项双盲随机对照试验 Xudong ZhaoHetong ZhouMinmin Wang Research 07 March 2026 Article: 242 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Impairment of brain short association fibers across clinical stages in amyotrophic lateral sclerosis: a new biomarker mirroring disease progression 肌萎缩侧索硬化症临床各阶段脑短联结纤维受损情况：一种反映疾病进展的新型生物标志物 Nao-Xin HuangZi-Wei CaiHua-Jun Chen Research 06 March 2026 Article: 241 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Social frailty and the risk of progression from health to physical, psychological, and cognitive multimorbidity: a prospective multi-cohort study 社会脆弱性与从健康状态进展至身体、心理及认知多病共存状态的风险：一项前瞻性多队列研究 Yaguan ZhouHtet Lin HtunYi Guo Research 06 March 2026 Article: 240 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 Association between early life constituent-specific PM2.5 exposure and child development and the moderating role of greenness: a nationwide study in China 中国全国范围内早期生命特定成分PM2.5暴露与儿童发育的关联及绿地调节作用的研究 Ruili LiXiaoguo ZhengXiaoning Lei Research 06 March 2026 Article: 239 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童及青少年精神病学 Intravenous thrombolysis versus standard medical therapy in minor stroke patients with large vessel severe stenosis or occlusion: a systematic review and meta-analysis 静脉溶栓与标准药物治疗轻型卒中合并大血管重度狭窄或闭塞患者的系统综述与荟萃分析 Tianhao ZhangLin TongZhigang Liang Research 06 March 2026 Article: 238 Long-term risk of offspring type 1 and type 2 diabetes following maternal gestational diabetes mellitus: a nationwide birth cohort study with 10-year follow-up 母亲妊娠期糖尿病后子女患1型和2型糖尿病的长期风险：一项为期10年随访的全国出生队列研究 Joon Ho MoonHan Na JungSung Hee Choi Research 06 March 2026 Article: 237 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题合集：妊娠期糖尿病的诊断与治疗 Parental income in childhood and health outcomes across age groups: a register-based study from Norway 童年期父母收入与各年龄段健康结局：一项基于挪威登记数据的研究 Bjørn-Atle RemeHans Fredrik SundeJonathan Wörn Research 06 March 2026 Article: 236 AI-based quality control was associated with improved fetal ultrasound image quality in low-resource settings: a real-world multicenter study from West China 基于人工智能的质量控制可改善低资源环境下胎儿超声图像质量：一项来自中国西部的现实多中心研究 Jianxin ZhaoYao TangYong Huang Research 06 March 2026 Article: 235 Reply to: Intraoperative use of sodium oxybate to prevent post-operative delirium in older patients undergoing major orthopedic surgery 回复：术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Meiying CuiHang XuePing Zhao Matters Arising 13 April 2026 Article: 234 Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis 无假设的循环代谢组学评估为肌萎缩侧索硬化症中能量底物可用性的细胞特异性作用提供见解 Elham AlhathliJohnathan Cooper-KnockPamela J. Shaw Research 06 March 2026 Article: 233 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Intraoperative use of sodium oxybate to prevent postoperative delirium in older patients undergoing major orthopedic surgery 术中使用羟丁酸钠预防老年患者接受大骨科手术后谵妄 Fu-Shan XueDan-Feng WangXiao-Chun Zheng Matters Arising 13 April 2026 Article: 232 Statin therapy and stroke risk in patients with hypercholesterolaemia: a population-based longitudinal study using electronic health records in South London 他汀类药物治疗与高胆固醇血症患者卒中风险：一项基于南伦敦电子健康记录的纵向人群研究 Marc DelordAbdel Douiri Research 05 March 2026 Article: 231 Thermal ablation versus hepatectomy for solitary colorectal liver metastases up to 5 cm: a multicenter target trial emulation on safety, efficacy, and cost-effectiveness 热消融与肝切除术治疗直径达5厘米的孤立性结直肠癌肝转移：一项关于安全性、疗效及成本效益的多中心目标试验模拟研究 Jianming LiLu LiPing Liang Research 05 March 2026 Article: 230 Why hyperinsulinemia is detrimental to weight loss: insights from type 1 diabetes 为何高胰岛素血症不利于减重：来自1型糖尿病的见解 Stephan MartinKerstin KempfHubert Kolb Debate 10 April 2026 Article: 229 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减重干预措施及其健康影响 Interventions to prevent and treat multiple long-term conditions and their consequences across the life course: concepts and definitions 预防和治疗多种长期疾病及其在生命周期中后果的干预措施：概念与定义 Miles D. WithamGuruprasad P. AithalThe Multiple Long-Term Conditions Cross-NIHR Collaboration Interventions and Prevention Workstream Forum 10 April 2026 Article: 228 Effectiveness of nirmatrelvir/ritonavir and molnupiravir on post-COVID diabetes risk among an older adult cohort: a target trial emulation study 奈玛特韦/利托那韦和莫努匹韦对老年人群新冠后糖尿病风险的影响：一项目标试验模拟研究 Zihao GuoYuchen WeiKa Chun Chong Research 17 March 2026 Article: 227 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Iron deficiency and dementia risk: evidence from the Swedish population-based cohort study AMORIS 瑞典基于人群的队列研究AMORIS中铁缺乏与痴呆风险的证据 Mozhu DingAlexandra WennbergKarin Modig Research 08 April 2026 Article: 226 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Effects of ultrasound-guided stellate ganglion block in poststroke bulbar palsy: a double-blind placebo-controlled trial 超声引导下星状神经节阻滞对脑卒中后球麻痹的影响：一项双盲安慰剂对照试验 Hongji ZengWeihong ZhangXi Zeng Research 04 March 2026 Article: 225 Dual-utility ctDNA in diffuse large B-cell lymphoma: integrated genotyping unveils minimal residual disease dynamics and subtype-specific clonal evolution 双用途循环肿瘤DNA在弥漫性大B细胞淋巴瘤中的应用：整合基因分型揭示微小残留病灶动态变化及亚型特异性克隆演变 Jin-Hua LiangYi-Fan WuWei Xu Research 04 March 2026 Article: 224 Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2pathogenic variant carriers: a prospective cohort study BRCA1和BRCA2致病性变异携带者患非乳腺、非卵巢癌的风险：一项前瞻性队列研究 Ruotong YangRobert J. MacInnisShuai Li Research 04 March 2026 Article: 223 Cardiovascular outcomes of intensive blood pressure control in patients with and without metabolic dysfunction-associated fatty liver disease: post hoc analysis of the CRHCP trial 在伴有和不伴有代谢功能障碍相关脂肪性肝病的患者中，强化血压控制的心血管预后：CRHCP试验的事后分析 Songyue LiuYangzhi YinXiaofan Guo Research 04 March 2026 Article: 222 The role of COPD and inhaled corticosteroids in major adverse cardiovascular events in cardiovascular-kidney-metabolic populations 慢性阻塞性肺疾病和吸入性糖皮质激素在心血管-肾脏-代谢人群主要不良心血管事件中的作用 Anne E. IoannidesEmily L. GraulJennifer K. Quint Research 04 March 2026 Article: 221 Ethnic differences in the burden of cardiovascular disease risk factors among adult residents of London: the TOGETHER study 伦敦成年居民心血管疾病风险因素负担的种族差异：TOGETHER研究 Fotios BarkasMalo DirouKausik K. Ray Research 03 March 2026 Article: 220 Development of a novel prognostic assessment tool for recurrent respiratory papillomatosis 复发性呼吸道乳头瘤病新型预后评估工具的开发 Satoshi YamadaTaro IkegamiKiyoshi Misawa Research 16 April 2026 Article: 219 Response to: Matters Arising in relation to “Evaluating agreement between individual nutrition randomised controlled trials and cohort studies – a meta-epidemiological study” 针对“评估个体营养随机对照试验与队列研究之间的一致性——一项元流行病学研究”的相关问题探讨 Julia StadelmaierGina BantleLukas Schwingshackl Matters Arising 09 April 2026 Article: 218 Concordance between nutritional cohorts and randomized trials: biological confirmation or statistical consequence? A re-analysis of Stadelmaier et al. 营养队列研究与随机试验之间的一致性：生物学证实还是统计学结果？对Stadelmaier等人的研究再分析 Matthew CalkinsIsaac NúñezAdrian Soto-Mota Matters Arising 09 April 2026 Article: 217 Multimorbidity patterns and 15-year trajectories of physical performance: a population-based study 多病共存模式与15年身体机能变化轨迹：一项基于人群的研究 Francesco PalmeseDavide Liborio VetranoFederico Triolo Research 25 March 2026 Article: 216 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 The need for clinical studies assessing whether weight loss improves functional outcome after stroke in diabetes 评估减肥是否改善糖尿病患者中风后功能预后的临床研究需求 Ellen VercalsterenMichael V. MazyaCesare Patrone Debate 24 March 2026 Article: 215 Targeting STE20-type kinase MST3 improves metabolic dysfunction-associated steatohepatitis without affecting hepatocellular carcinoma development in mice 靶向STE20型激酶MST3可改善小鼠代谢功能障碍相关脂肪性肝炎，且不影响肝细胞癌的发展 Jingjing ZhangXiangdong GongyeMargit Mahlapuu Research 24 March 2026 Article: 214 Multimorbidity patterns and the subsequent risk of albuminuria: findings from the Stockholm Creatinine Measurements (SCREAM) project 多病共存模式与后续白蛋白尿风险：来自斯德哥尔摩肌酐测量（SCREAM）项目的研究结果 Giorgi BeridzePatrick B. MarkJuan-Jesus Carrero Research 24 March 2026 Article: 213 Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma 胶质母细胞瘤神经元微环境中髓系来源的免疫抑制对嵌合抗原受体T细胞的影响 Junyi ZhangJasmin von EhrYahaya A. Yabo Research 13 March 2026 Article: 212 Associations of genetically predicted interleukin-6 and tumor necrosis factor signaling pathways with mortality among persons with colorectal cancer: a two-sample Mendelian randomization 基因预测的白细胞介素-6和肿瘤坏死因子信号通路与结直肠癌患者死亡率之间的关联：一项双样本孟德尔随机化研究 Martina BoukaKatharina NimptschTobias Pischon Research 06 March 2026 Article: 211 Disruption of the angiopoietin-like system connects lipid homeostasis and hypothalamic dysfunction in ALS 血管生成素样系统紊乱将肌萎缩侧索硬化症中的脂质稳态与下丘脑功能障碍关联起来 Sruthi Sankari KrishnamurthyAdriana Zardini BuzattoFrancesco Roselli Research 03 March 2026 Article: 210 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Day+30 detection of minimal residual FLT3-ITD by high-sensitivity PCR-NGS predicts relapse risk and guides post-transplant maintenance in AML 移植后第30天通过高灵敏度PCR-NGS检测微小残留FLT3-ITD可预测急性髓系白血病（AML）复发风险并指导移植后维持治疗 Shan JiangDan FengErlie Jiang Research 03 March 2026 Article: 209 Early childhood weight gain and alanine aminotransferase at age 8: an adjunct study of the Japan Environment and Children’s Study 幼儿期体重增长与8岁时丙氨酸氨基转移酶水平：日本环境与儿童研究的一项辅助研究 Naw Awn J-PKeiko YamasakiNarufumi Suganuma Research 03 March 2026 Article: 208 Anti-CD19 chimeric antigen receptor T-cell therapy for relapsed or refractory Philadelphia chromosome-positive B cell acute lymphoblastic leukemia: a multicenter retrospective study 抗CD19嵌合抗原受体T细胞疗法治疗复发或难治性费城染色体阳性B细胞急性淋巴细胞白血病：一项多中心回顾性研究 Jinglei YuFengmei SongGuoqing Wei Research 03 March 2026 Article: 207 Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics 通过单细胞和空间转录组学鉴定人类卵巢皮质中的冷敏感生态位及可靶向的FOS/AP-1程序 Fanghao GuoDi SunWen Li Research 03 March 2026 Article: 206 Neoadjuvant camrelizumab combined with metronomic chemotherapy in patients with advanced esophageal squamous cell carcinoma: a pilot randomized phase 2 trial 卡瑞利珠单抗联合节拍化疗新辅助治疗晚期食管鳞状细胞癌：一项随机2期初步试验 Zhiming ChenWenshuai LiJie Liu Research 03 March 2026 Article: 205 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症临床试验 Vericiguat for endothelial dysfunction and CRT response in non-responders: the VERCET prospective observational study 维利西呱治疗无反应者的内皮功能障碍和心脏再同步化治疗（CRT）反应：VERCET前瞻性观察研究 Celestino SarduLudovica Vittoria MarfellaRaffaele Marfella Research 03 March 2026 Article: 204 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病和心律失常 Assessment of antibody responses to Anopheles SG6-P1 and Aedes N-term 34kDa salivary peptides: a randomised human-challenge trial of controlled exposures to vector bites 评估针对按蚊SG6-P1和伊蚊N端34 kDa唾液肽的抗体反应：一项对媒介叮咬进行可控暴露的随机人体挑战试验 Victor ChaumeauEllen A. KearneyFreya J. I. Fowkes Research 02 March 2026 Article: 203 Is random biopsy necessary for normal esophageal mucosa during chromoendoscopy? Evidence from a population-based cohort study 在色素内镜检查过程中，对于正常食管黏膜是否有必要进行随机活检？一项基于人群的队列研究证据 Wenlei YangMengfei LiuYang Ke Research 02 March 2026 Article: 202 Sinusoidal cell–derived biomarker scores predict diagnosis and prognosis in chronic liver disease 窦状隙细胞来源的生物标志物评分可预测慢性肝病的诊断和预后 Sergi Guixé-MuntetAnabel Fernández-IglesiasJordi Gracia-Sancho Research 28 February 2026 Article: 201 Anticholinergic drug burden and incident cardiovascular events: a population-based study 抗胆碱能药物负担与新发心血管事件：一项基于人群的研究 Nanbo ZhuMaria EriksdotterHong Xu Research 28 February 2026 Article: 200 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Sensitive periods of BMI change from childhood to adulthood on subclinical cardiovascular outcomes: a 36-year prospective cohort study 从儿童期到成年期体重指数（BMI）变化对亚临床心血管结局影响的敏感期：一项为期36年的前瞻性队列研究 Hui YangTongshuai GuoJianjun Mu Research 27 February 2026 Article: 199 Feasibility and preliminary efficacy of an art-making program to manage fear of cancer recurrence (AM-I-FCR) in lung cancer patients: a randomized controlled pilot study 艺术创作项目（AM-I-FCR）管理肺癌患者对癌症复发恐惧的可行性与初步疗效：一项随机对照试点研究 Jialing LinZhixuan KangFeifei Huang Research 27 February 2026 Article: 198 Unveiling disparities in lung cancer care: a joint spatio-temporal analysis of multidisciplinary meeting presentation, supportive care screening, and diagnostic timeliness in Victoria 揭示肺癌诊疗差异：维多利亚州多学科会诊展示、支持性护理筛查及诊断及时性的联合时空分析 Getayeneh Antehunegn TesemaRob G. StirlingArul Earnest Research 27 February 2026 Article: 197 Transcriptome-based high-frequency recurrence index predicts frequent recurrence in non-muscle-invasive bladder cancer after Bacillus Calmette-Guérin therapy 基于转录组的高频复发指数可预测卡介苗治疗后非肌层浸润性膀胱癌的频繁复发情况 Seung-Woo BaekYoung Joon ByunSeok Joong Yun Research 27 February 2026 Article: 196 Life-course influence of birthweight and subsequent pathways on healthy aging: a Mendelian randomization study 出生体重对健康老龄化的终身影响及后续途径：一项孟德尔随机化研究 Lijie KongChun DouTiange Wang Research 25 February 2026 Article: 195 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study 常规炎症指标改变接受经皮冠状动脉介入治疗患者的克隆性造血相关预后风险：一项现实队列研究 Xuxiang ShenYing SongXiangfeng Lu Research 25 February 2026 Article: 194 Health experiences and outcomes of autistic and non-autistic adults with hypermobile Ehlers-Danlos syndrome and hypermobility spectrum disorder 自闭症和非自闭症成年孤独症患者及非孤独症患者中患有高迁移率埃勒斯-丹洛斯综合征和高迁移率谱系障碍者的健康体验和预后 Catherine J. CromptonThemis N. EfthimiouKathryn M. Berg Research 25 February 2026 Article: 193 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of non-pharmacological interventions on sleep quality in older adults: a systematic review and network meta-analysis of randomized controlled trials 非药物干预措施对老年人睡眠质量影响：基于随机对照试验的系统综述和网络荟萃分析 Jia SongHeng DongShangfeng Tang Research 25 February 2026 Article: 192 Cortical excitability mapping stratifies neurobiological subtypes of schizophrenia with genetic and molecular signatures 皮质兴奋性映射对具有遗传和分子特征的精神分裂症神经生物学亚型进行分层 Sixuan GuoYu ZhaoQiyong Gong Research 25 February 2026 Article: 191 Minimum 18-week chemotherapy improves survival in locally advanced rectal cancer after neoadjuvant radiotherapy: a post hoc analysis of the STELLAR trial 新辅助放疗后局部晚期直肠癌患者接受至少18周化疗可改善生存率：STELLAR试验的事后分析 Tongzhen XuHuiying MaJing Jin Research 25 February 2026 Article: 190 Helminth coinfections mitigate clinical, parasitological, and immune outcomes in Mozambican children with malaria 在莫桑比克患疟疾的儿童中，蠕虫共感染可减轻临床、寄生虫学和免疫学转归 Inocência CuambaRebeca SantanoCarlota Dobaño Research 31 March 2026 Article: 189 Effectiveness of group-based art interventions for late-life depression: a systematic review and meta-analysis of randomized controlled trials 团体艺术干预对老年抑郁症的疗效：一项针对随机对照试验的系统综述和荟萃分析 Mohamad AzhdarlooRaziyeh AtaeiAbouzar Nazari Research 24 February 2026 Article: 188 The associations of consultant sex on herding‑like prescribing behaviour: evidence from a web-based experiment with female primary care physicians in England 顾问性别对从众式处方行为的影响：来自一项针对英格兰女性初级保健医生的网络实验的证据 Sandro Tiziano StoffelMatthias SchwenkglenksBerna Cennet Özdemir Research 24 February 2026 Article: 187 Tricarboxylic acid cycle metabolite index predicts adverse outcomes in acute myocardial infarction patients 三羧酸循环代谢物指数预测急性心肌梗死患者的不良预后 Ye WangPengyan WuBo Yu Research 24 February 2026 Article: 186 Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids 靶向癌症干细胞可预测腹水来源的卵巢癌类器官的反应并逆转化疗耐药性 Xiaoli ZhangWen ZhangHuiqin Guo Research 24 February 2026 Article: 185 Neural vulnerability to stress in adolescents: a longitudinal study using polyconnectomic scoring of depression risk 青少年神经对压力的易感性：一项使用抑郁风险多连接组评分进行的纵向研究 Yuan LiuMeijuan LiJie Li Research 24 February 2026 Article: 184 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Classification of ALS molecular subtypes: a literature review on machine learning applications and their clinical value 肌萎缩侧索硬化症分子亚型分类：机器学习应用及其临床价值的文献综述 John K. JammalEsteban A. GomezAlfredo Iacoangeli Review 23 February 2026 Article: 183 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题合集：肌萎缩侧索硬化症：最新进展与新动态 Can we protect refugee children from mental health problems?— a scoping review of modifiable factors to inform preventive interventions 我们能否保护难民儿童免受心理健康问题困扰？——一项旨在为预防性干预提供信息的可改变因素的范围性综述 Rita GonçalvesM J MarquesSónia Dias Research 23 February 2026 Article: 182 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 The Trial Bank initiative to promote trustworthy living evidence for medication safety (PROMISE) of children: design and pilot validation 促进儿童用药安全可信实时证据（PROMISE）的试验库计划：设计与初步验证 Chang XuSuhail A. DoiPROMISE Collaborative Research Network Research 21 February 2026 Article: 181 Is liquid biopsy a cost-effective method to diagnose Burkitt Lymphoma in children and young adults? A health economic evaluation in Tanzania 液体活检是否为诊断坦桑尼亚儿童和青年成人伯基特淋巴瘤的一种具有成本效益的方法？一项卫生经济学评估 Jingjing JiangLiz MorrellAI-REAL Consortium Research 21 February 2026 Article: 180 The influence of immunohistochemistry-based subtypes on overall survival in breast cancer spine metastases: a systematic review and meta-analysis 基于免疫组织化学的亚型对乳腺癌脊柱转移总生存期的影响：一项系统综述和荟萃分析 Fon-Yih TsuangYun-Heng LiChung Liang Chai Research 21 February 2026 Article: 179 Prenatal exposure to maternal asthma and asthma medication and neurodevelopmental outcomes: a population cohort study of 179,024 children 产前接触母体哮喘及哮喘药物与神经发育结局的关系：一项针对179,024例儿童的人群队列研究 Lama A. ShakhshirSarjit SinghMichael Fleming Research 20 February 2026 Article: 178 First-in-human phase 1/2a study of T3011, an oncolytic HSV expressing IL-12 and PD-1 antibody, administered via intratumoral (IT) injection as monotherapy in advanced solid tumors, including recurrent or metastatic HNSCC T3011（一种表达IL-12和PD-1抗体的溶瘤性单纯疱疹病毒）首次人体1/2a期研究：通过瘤内（IT）注射作为单一疗法治疗包括复发或转移性头颈部鳞状细胞癌在内的晚期实体瘤 Dongmei JiWenmin FuXichun Hu Research 20 February 2026 Article: 177 Expanding access to cerebrovascular imaging with routine MRI for pre-surgical assessment of intracranial tumor patients: an AI model development and multi-center validation study 利用常规MRI扩大脑血管成像在颅内肿瘤患者术前评估中的应用范围：一项人工智能模型开发与多中心验证研究 Chaoyue ChenZhouyang HuangJianguo Xu Research 20 February 2026 Article: 176 Changing landscape of physical fitness and urban–rural inequalities: evidence from 1.2 million children and adolescents over 20 years of urbanization 20年城市化进程中120万例儿童和青少年体质健康状况及城乡差异的变化 Shan CaiJiaxin LiYi Song Research 19 February 2026 Article: 175 Efficacy and safety of anti-prediabetic drugs in patients with prediabetes: a Bayesian network meta-analysis 抗糖尿病前期药物在糖尿病前期患者中的疗效和安全性：一项贝叶斯网状荟萃分析 Yike WuZihan WangGuo Ma Research 19 February 2026 Article: 174 Clonal haematopoiesis of indeterminate potential and risk of incident psychiatric disorders Yuefeng YuChenyi WanNingjian Wang 意义未明的克隆性造血与新发精神障碍风险 Research 18 February 2026 Article: 173 Spatial characterization of intrahepatic fat deposition across steatotic liver disease subcategories: a multicenter study 脂肪性肝病各亚类中肝内脂肪沉积的空间特征：一项多中心研究 Yan-Ci ZhaoMin WangFeng Chen Research 18 February 2026 Article: 172 Pregnancy outcomes among medically complex populations with high risk of pregnancy mortality in Virginia: a retrospective observational study 弗吉尼亚州妊娠死亡高风险医学复杂人群的妊娠结局：一项回顾性观察研究 Michael J. GreenLauren G. AndersonJonas J. Swartz Research 18 February 2026 Article: 171 Maternal amino acid metabolites during pregnancy and preterm birth: results from two prospective cohort studies 孕期母体氨基酸代谢物与早产的关系：两项前瞻性队列研究的结果 Jingnan ChenYidan DongJu-Sheng Zheng Research 18 February 2026 Article: 170 Correction: Trajectory of the body weight after drug discontinuation in the treatment of anti-obesity medications 更正：停用抗肥胖药物后体重的变化轨迹 Han WuWenjia YangLinong Ji Correction 25 March 2026 Article: 169 Physical activity patterns and cardiovascular disease risk in adults with overweight or obesity: a prospective cohort study 超重或肥胖成人身体活动模式与心血管疾病风险：一项前瞻性队列研究 Kai MuYanan QiaoBo Xi Research 16 February 2026 Article: 168 Part of 1 collection:Weight loss interventions and their health impacts 所属专题合集：减肥干预措施及其对健康的影响 Maternal migraine and offspring ADHD: triangulating the evidence 母亲偏头痛与后代多动症（ADHD）：多方证据综合分析 Yaxin LuoChristina DardaniEvie Stergiakouli Research 14 February 2026 Article: 167 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 An autonomous siRNA delivery system targeting NLRP3: implications in Parkinson’s disease 靶向NLRP3的自主性小干扰RNA（siRNA）递送系统：在帕金森病中的潜在意义 Lishan LinZhizong LiZhong Pei Research 12 February 2026 Article: 166 Lay descriptions of painful temporomandibular disorders—an international consensus proposal for Global Burden of Disease estimates 颞下颌关节紊乱病疼痛的通俗描述——全球疾病负担评估的国际共识提案 A. LövgrenP. LivP. Svensson Research 17 March 2026 Article: 165 Association of soluble tumor necrosis factor receptor 1 with tau pathology, brain atrophy, and cognitive decline: a longitudinal study 可溶性肿瘤坏死因子受体1与tau蛋白病变、脑萎缩及认知功能下降的关联：一项纵向研究 Yutong ZhangLulu SunAlzheimer’s Disease Neuroimaging Initiative Research 11 February 2026 Article: 164 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Particulate matter and respiratory health in middle-aged and older adults: disentangling size-fractionated and constituent-specific effects under China’s clean-air policies 颗粒物与中老年人呼吸系统健康的关系：厘清中国净化空气政策下不同粒径及成分的特定影响 Yujing ChenZhaoyan LiuYu-ming Chen Research 11 February 2026 Article: 163 Part of 1 collection:Climate change and human health 所属专题合集：气候变化与人类健康 Clinical impact and cost-effectiveness of vaccinating infants and adolescents against invasive meningococcal B disease in the Netherlands 荷兰为婴儿和青少年接种针对侵袭性脑膜炎球菌B病的疫苗的临床影响和成本效益 Thomas OttenMirjam KnolAnneke Steens Research 10 February 2026 Article: 162 Association between trajectories of sleep quality and postpartum depression: a group-based trajectory model and computer-simulated network analysis 睡眠质量轨迹与产后抑郁之间的关联：基于组别的轨迹模型和计算机模拟网络分析 Xiaoxiao MeiJinzhou YuZengjie Ye Research 10 February 2026 Article: 161 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Understanding Japan’s mortality advantage: a comparison of mortality in independent and dependent older adults in Japan and Sweden 解读日本在死亡率方面的优势：日本与瑞典独立生活及依赖他人生活老年人的死亡率比较 Shunsuke MurataMarcus EbelingKarin Modig Research 23 March 2026 Article: 160 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学及风险因素的作用 The Young Adult Sleep model: an evolving causal loop diagram of mental health dynamics 青年睡眠模型：心理健康动态演变的因果环路图 Jeroen F. UlemanRushd F. M. Al-ShamaNaja Hulvej Rod Research 16 March 2026 Article: 159 Part of 1 collection:Sleep and mental health 所属专题合集：睡眠与心理健康 Oncostatin-M ligand-based CAR-T therapy displays robust anti-tumor activity against osteosarcoma 基于抑瘤素M配体的CAR-T疗法对骨肉瘤显示出强大的抗肿瘤活性 Daniel FeinbergVinayak UppinReshmi Parameswaran Research 17 March 2026 Article: 158 Antimicrobial catheters coated with poly-L-lysine for the prevention of bacteriuria in adults requiring short-term catheterization: a multicenter randomized controlled trial 涂有聚-L-赖氨酸的抗菌导管预防短期导尿成人患者菌尿症：一项多中心随机对照试验 Xinfei LiJun LiuKai Zhang Research 09 February 2026 Article: 157 Penpulimab in combination with lenalidomide and R-GemOx regimen (R2-GemOx-PD1i) in relapsed or refractory diffuse large B-cell lymphoma: a multicenter, single-arm, phase 2 trial 派安普利单抗联合来那度胺和R-GemOx方案（R2-GemOx-PD1i）治疗复发或难治性弥漫性大B细胞淋巴瘤：一项多中心、单臂、2期试验 Jin-Hua LiangTong-Yao XingWei Xu Research 09 February 2026 Article: 156 Digital twin brain reveals state-specific stimulation targets for abnormal brain dynamics in tinnitus 数字孪生大脑揭示耳鸣异常脑动力学状态特异性刺激靶点 Jiaqi ZhangShuting HanTianzi Jiang Research 10 February 2026 Article: 155 The case for mandatory reporting to enable targets for healthy and environmentally sustainable food: means, motive and opportunity 强制报告实现健康且环境可持续食物目标的理由：方法、动机和机会 Rachel PecheyLauren BandySusan A. Jebb Debate 10 February 2026 Article: 154 Genetic insights into radiomic and proteomic changes under β1-blockers treatment in hypertensive heart disease and hypertrophic cardiomyopathy β1受体阻滞剂治疗高血压性心脏病和肥厚型心肌病时放射组学和蛋白质组学变化的遗传学见解 Zhe ChenYifan TangKai Xie Research 09 February 2026 Article: 153 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Optimizing drug-resistant tuberculosis diagnosis: cost-effectiveness of rapid molecular and phenotypic assays in South Africa 优化耐药结核病诊断：南非快速分子和表型检测方法的成本效益分析 Ginenus FekaduTadesse TolossaWai Kit Ming Research 09 February 2026 Article: 152 Maternal smoking based on pre-birth health examination and risk of neurodevelopmental disorders in offspring: insights from a Korean mother–child cohort 基于产前健康检查探讨母亲吸烟与后代神经发育障碍风险的关系：来自韩国母婴队列研究的见解 Chan Soon ParkMoonyoung JangJun-Bean Park Research 11 March 2026 Article: 151 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Effects of ablation versus drug therapy on clinical outcomes and quality of life by frailty status in atrial fibrillation: a post hoc analysis of the CABANA trial 根据衰弱状态分析消融术与药物治疗对心房颤动患者临床预后和生活质量的影响：CABANA试验的事后分析 Lili WangYanguang LiYunlong Wang Research 07 February 2026 Article: 150 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题合集：心肌病与心律失常 Quantifying lifetime risk for 1,401 infectious diseases across the diabetes spectrum using a Bayesian approach 采用贝叶斯方法量化糖尿病全病程中1401种传染病的终生风险 Boomer B. OlsenMartin Tristani-FirouziEdgar Javier Hernandez Research 07 February 2026 Article: 149 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与传染病 Risk assessment of asthma and allergic rhinitis in atopic dermatitis patients treated with biologics and JAK inhibitors: a systematic review and network meta-analysis of randomized controlled trials 对接受生物制剂和JAK抑制剂治疗的特应性皮炎患者罹患哮喘和过敏性鼻炎的风险评估：一项针对随机对照试验的系统综述和网络荟萃分析 Liling ZengTong ZhouJing Li Research 07 February 2026 Article: 148 Preclinical activity of brincidofovir in peripheral T-cell and NK/T-cell lymphoma 布林西多福韦（brincidofovir）在外周T细胞和NK/T细胞淋巴瘤中的临床前活性 Jason Yongsheng ChanElizabeth Chun Yong LeeChoon Kiat Ong Research 06 February 2026 Article: 147 Genetic risk factors modulate the association between physical activity and colorectal cancer 遗传风险因素调节身体活动与结直肠癌之间的关联 Anita R. PeoplesMireia Obón-SantacanaVictor Moreno Research 05 February 2026 Article: 146 A neuroimaging biomarker for disease staging in clinically diagnosed Alzheimer’s disease 临床诊断阿尔茨海默病的疾病分期神经影像学标志物 Zhuangzhuang LiShaozhen YanYong Liu Research 05 February 2026 Article: 145 Association of GLP-1 receptor agonists with herpes risks in diabetes mellitus: a target trial emulation 胰高血糖素样肽-1（GLP-1）受体激动剂与糖尿病中疱疹风险的关联：一项目标试验模拟研究 Chi-Hsien HuangI-Hui ChiangJames Cheng-Chung Wei Research 31 December 2025 Article: 144 Part of 1 collection:Diabetes and infectious disease 所属专题合集：糖尿病与感染性疾病 Neoadjuvant immunochemotherapy plus thymalfasin in locally advanced gastric cancer: a prospective clinical trial 局部晚期胃癌联合胸腺肽的新辅助免疫化疗：一项前瞻性临床试验 Hao XuFengyuan LiZekuan Xu Research 26 February 2026 Article: 143 Part of 1 collection:Clinical trials for gastrointestinal cancer 所属专题合集：胃肠道癌症的临床试验 Detection of sequelae from acute meningitis during clinical review by a healthcare provider: a systematic review and meta-analysis 临床医生在临床复查中检测急性脑膜炎后遗症：一项系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Research 28 February 2026 Article: 142 Part of 1 collection:Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 ISG15-driven immune modulation and tumor progression in breast cancer metastasis: insights from single-cell and spatial transcriptomics ISG15驱动的免疫调节与乳腺癌转移中的肿瘤进展：来自单细胞和空间转录组学的见解 Hua ShaoHanlu TangYongqing Xu Research 04 February 2026 Article: 141 Evaluating the impact of family history and polygenic risk scores on cardiometabolic disease risk 评估家族史和多基因风险评分对心代谢疾病风险的影响 Ebuka OnyenobiKnightess OyiboSally N. Adebamowo Research 03 February 2026 Article: 140 Social networking site use, depressive and anxiety symptoms in adolescents: evidence from a longitudinal cohort study (SCAMP) 社交网站使用与青少年抑郁和焦虑症状：来自纵向队列研究（SCAMP）的证据 Chen ShenBraulio M. Girela-SerranoMireille B. Toledano Research 03 February 2026 Article: 139 Part of 1 collection:Child and adolescent psychiatry 所属专题合集：儿童与青少年精神病学 Early gestational prediction of spontaneous preterm birth using a validated three-protein serum biomarker panel 使用经验证的三蛋白血清生物标志物组合进行早孕期自发性早产预测 Qiong LuoJuan WeiXuefeng B. Ling Research 02 February 2026 Article: 138 Household cannabis cessation and adolescent mental health outcomes in a prospective cohort study 一项前瞻性队列研究中家庭大麻戒断与青少年心理健康预后的关系 Ming WangYixiang XuFei Li Research 02 February 2026 Article: 137 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题合集：精神活性物质：娱乐性药物重新利用为新型疗法 Objective assessment of long-term impact of COVID-19 on multiple sensory functions 客观评估新冠肺炎对多种感觉功能的长期影响 Ahmad OdehVeronica L. FormanekKai Zhao Research 27 February 2026 Article: 136 Detection of hearing loss by formal audiological testing after acute infectious meningitis: a global systematic review and meta-analysis 急性感染性脑膜炎后通过正式听力检测诊断听力损失：一项全球系统综述和荟萃分析 Luisa F. AlvizCarla Y. KimKiran T. Thakur Review 28 February 2026 Article: 135 Part of 1 collection: Acute meningitis: a collection of systematic reviews 所属专题合集：急性脑膜炎：系统综述合集 Serological evidence of substantial respiratory syncytial virus infection burden among older adults residing in Swedish long-term care facilities 血清学证据表明，居住在瑞典长期护理机构中的老年人存在沉重的呼吸道合胞病毒感染负担 Preeti MoarChristoffer GranvikMattias N. E. Forsell Research 24 February 2026 Article: 134 Association of parental education with offspring psychiatric diagnoses, violent crimes, and suicidal behavior: a nationwide Swedish quasi-experimental study 父母受教育程度与后代精神疾病诊断、暴力犯罪和自杀行为之间的关联：一项瑞典全国范围的准实验研究 Mengping ZhouHenrik LarssonErik Pettersson Research 26 February 2026 Article: 133 Discriminative performance of externally validated dementia risk prediction models: a systematic review and meta-analysis 外部验证的痴呆风险预测模型的鉴别性能：一项系统综述和荟萃分析 Blossom C. M. StephanJacob BrainMario Siervo Research 02 February 2026 Article: 132 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题合集：健康老龄化与长寿：预防医学和风险因素的作用 Efficacy and safety of intravenous administration of high-dose selenium for preventing chemotherapy-induced peripheral neuropathy in platinum-sensitive recurrent ovarian cancer: a phase 3, double-blind, parallel group, randomized controlled pilot study 静脉注射大剂量硒预防铂敏感复发性卵巢癌化疗所致周围神经病变的有效性和安全性：一项3期、双盲、平行组、随机对照试点研究 Ga Won YimKyung Hee HanHee Seung Kim Research 02 February 2026 Article: 131 Time for change in implementation research and practice 实施研究和实践中变革的时机已到 Mike EnglishJacob McKnightSebastian Fuller Debate 02 February 2026 Article: 130 CardioMetAge estimates cardiometabolic aging and predicts disease outcomes CardioMetAge可评估心脏代谢年龄并预测疾病结局 Yucan LiXinming XuKelin Xu Research 31 January 2026 Article: 129 Disproportionate climate burden of rising temperatures on low birth weight in Pakistan 气温上升给巴基斯坦低出生体重儿带来的不成比例的气候负担 Syeda H. FatimaCorey J. A. BradshawZohra S. Lassi Research 31 January 2026 Article: 128 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Enhancing oncolytic virotherapy with a tri-specific T-cell engager targeting CD3ε, EpCaM, and 4-1BB: preclinical evaluation and implications for cancer immunotherapy 利用靶向CD3ε、EpCaM和4-1BB的三特异性T细胞衔接器增强溶瘤病毒疗法：临床前评估及对癌症免疫疗法的启示 Zhongyi DongHaoyu ZhangZizhen Zhang Research 30 January 2026 Article: 127 Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma 靶向降解BCL-XL与吉西他滨联用对胆管癌具有协同治疗作用 Qinghua ZengYan ZhangYonghan He Research 30 January 2026 Article: 126 Association of DNA methylation with hypertension and blood pressure: a 7-year longitudinal study from KORA F4/FF4 DNA甲基化与高血压及血压的关联：来自KORA F4/FF4的7年纵向研究 Liye LaiAngelina Shin Yee JongMelanie Waldenberger Research 04 February 2026 Article: 125 Shared genetic architecture of psychoactive substance use and pan-cancer: insights from a large‑scale genome‑wide cross‑trait analysis 精神活性物质使用与泛癌症的共享遗传结构：来自大规模全基因组跨性状分析的见解 Jiahang SongPengzhu LiOlivier Gires Research 05 February 2026 Article: 124 Part of 1 collection: Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：作为新型疗法的娱乐性药物再利用 Intrauterine exposure to maternal diabetes and the risk of developing epilepsy in children: a national cohort study of 2.3 million children 宫内暴露于母体糖尿病与儿童患癫痫风险的关系：一项针对230万儿童的全国队列研究 Muhammad Zakir HossinMartina PerssonNeda Razaz Research 14 February 2026 Article: 123 ADHD and adherence to antihypertensive medication treatment: a multinational cohort study 多动症与坚持抗高血压药物治疗的关系：一项多国队列研究 Honghui YaoYiling ZhouZheng Chang Research 20 February 2026 Article: 122 How effective is rejoining a long-term weight loss program? The 5- and 10-year MRI-assessed Follow Interventions Trial (FIT) project 重新加入长期减肥计划的效果如何？5年和10年磁共振成像评估的随访干预试验（FIT）项目 Hadar KleinDafna PachterIris Shai Research 30 January 2026 Article: 121 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减肥干预措施及其对健康的影响 Correction: Brain state dynamics and working memory in patients with schizophrenia and unaffected siblings 更正：精神分裂症患者及其未受影响兄弟姐妹的脑状态动态与工作记忆 Feiwen WangJie YangLena Palaniyappan Correction 20 February 2026 Article: 120 Ocular light and optical radiation exposure as a modifiable environmental determinant of health: expert consensus on research gaps and priorities 作为可改变的环境健康决定因素的眼睛光暴露和光学辐射暴露：关于研究空白和优先事项的专家共识 Manuel SpitschanAnna M. BillerJohannes Zauner Guideline 29 January 2026 Article: 119 Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study 青少年饮食模式与神经心理功能：一项横断面和纵向研究 Alexios ManidisNicolas Ayala-AldanaJordi Julvez Research 29 January 2026 Article: 118 Part of 1 collection: Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Factors impacting the delivery of contextualized care in serious illness: a focus group study with healthcare professionals 影响危重症患者情境化护理实施的因素：一项针对医疗保健专业人员的焦点小组研究 Linda ModderkolkYvonne SchoonAnne B. Wichmann Research 29 January 2026 Article: 117 Part of 1 collection: Palliative care and medicine 所属专题：姑息治疗与医学 Early interventions for first onset of symptoms of mental health conditions: an umbrella review of systematic reviews 针对心理健康问题首次出现症状的早期干预措施：一项系统综述的伞式评价 Jasmine LeePhoebe BarnettSonia Johnson Research 29 January 2026 Article: 116 Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone 局灶性癫痫发作间期脑电图信号中嵌入的谐波模式：对致痫区的新见解 Lingli HuLingqi YeShuang Wang Research 28 January 2026 Article: 115 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题合集：癫痫：发作预防、治疗和流行病学 Effects of aerobic or resistance exercise on sleep and cancer-related fatigue in patients with breast cancer during or after neoadjuvant chemotherapy: a 3-arm randomized controlled trial 有氧运动或抗阻运动对新辅助化疗期间或之后乳腺癌患者睡眠和癌症相关疲劳的影响：一项三臂随机对照试验 Alexander HaussmannMartina E. SchmidtKaren Steindorf Research 28 January 2026 Article: 114 Neutrophil methylmalonic acid promotes microthrombus formation and adverse cardiac remodeling post-myocardial infarction through activating IL-6 signaling pathway-mediated NETosis 中性粒细胞甲基丙二酸通过激活IL-6信号通路介导的中性粒细胞胞外诱捕网形成（NETosis），促进心肌梗死后微血栓形成和不良心脏重构 Yige LiuJiaxin WangShaohong Fang Research 28 January 2026 Article: 113 Statistical approaches to analyse the combined effect of seven air pollutants and breast cancer risk: a case–control study nested in the French E3N-Generations cohort 分析七种空气污染物联合作用与乳腺癌风险关系的统计方法：一项嵌套于法国E3N-Generations队列的病例对照研究 Camille GiampiccoloBéatrice FerversAmina Amadou Research 28 January 2026 Article: 112 Part of 1 collection: Carcinogens and human health 所属专题合集：致癌物与人类健康 Is behaviour change communication guidance for general practice healthcare professionals evidence based? A systematic review 针对全科医疗保健专业人员的行为改变沟通指导是否具有循证依据？一项系统综述 Anika Schwarze-ChintapatlaJonathan Livingstone-BanksCharlotte Albury Research 16 February 2026 Article: 111 Patient-centred postpartum care provision: virtual delivery, tiered escalation, and tensions between efficiency, preference, and clinical concern 以患者为中心的产后护理服务提供：虚拟服务模式、分级转诊机制，以及效率、患者偏好与临床关切之间的矛盾 Sergio A. SilverioJulia R. B. BrownEmma L. Duncan Research 24 February 2026 Article: 110 Ethical dilemmas in climate change and healthcare delivery: a cross-sectional survey of US patient perspectives 气候变化与医疗服务中的伦理困境：一项针对美国患者观点的横断面调查 Andrew HantelEmily SenayGregory A. Abel Research 27 January 2026 Article: 109 Part of 1 collection: Climate change and human health 所属专题：气候变化与人类健康 Inetetamab plus camrelizumab and utidelone for pretreated HER2-positive advanced breast cancer: a prospective, single-arm, phase 2 study 伊尼妥单抗联合卡瑞利珠单抗和优替德隆治疗既往接受过治疗的HER2阳性晚期乳腺癌：一项前瞻性、单臂、2期研究 Huimin LvTao SunMin Yan Research 27 January 2026 Article: 108 Potential of earlier primary care health checks for prevention of cardiovascular events in younger age groups: population-based study in the United Kingdom 早期初级保健健康检查对预防年轻人群心血管事件的潜力：英国一项基于人群的研究 Catherine A. ScottLinxin LiPeter M. Rothwell Research 24 January 2026 Article: 107 Comparative effects of salt substitutes on blood pressure, cardiovascular events and mortality: a systematic review and network meta-analysis 盐替代品对血压、心血管事件和死亡率影响的比较：一项系统综述和网络荟萃分析 Honghao LaiGihad NesrallahBradley C. Johnston Research 23 January 2026 Article: 106 Association of short-term exposure to ambient air pollutants with liver function and mediation by fasting insulin: evidence from a rural cohort in China 短期暴露于环境空气污染物与肝功能的关系及空腹胰岛素的中介作用：来自中国农村队列研究的证据 Mengxin WangAogang ZhangWeidong Wu Research 23 January 2026 Article: 105 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Adjuvant tislelizumab, lenvatinib, and capecitabine for resected biliary tract cancer: a prospective phase II trial 辅助治疗：替雷利珠单抗、仑伐替尼和卡培他滨用于可切除的胆道癌：一项前瞻性II期试验 Yun FengNing ZhangLu Wang Research 23 January 2026 Article: 104 Comparative effectiveness of sleeve gastrectomy and semaglutide for weight loss and metabolic outcomes: a prospective non-randomized study 袖状胃切除术与司美格鲁肽对减重及代谢结局的疗效比较：一项前瞻性非随机研究 Yutung YenQian ZhangYi Chen Research 22 January 2026 Article: 103 Part of 1 collection:Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Impact of sex on outcomes in patients treated with drug-coated balloons versus drug-eluting stents for de novo coronary artery lesions: Insights from the REC-CAGEFREE I trial 性别对接受药物涂层球囊与药物洗脱支架治疗的新发冠状动脉病变患者预后的影响：来自REC-CAGEFREE I试验的见解 Ping WangJingyu ZhouLing Tao Research 22 January 2026 Article: 102 Assessing the comorbidity between asthma and depression through polygenic risk scoring and time-to-event models 通过多基因风险评分和时间事件模型评估哮喘与抑郁的共病情况 Xueting WangJun HeRenato Polimanti Research 22 January 2026 Article: 101 Persistent immune, coagulation and cardiac dysregulation are correlated with later post-discharge mortality in children with severe malnutrition 严重营养不良儿童出院后持续存在的免疫、凝血和心脏功能失调与后期死亡率相关 Brenda KamauEvans O. MudiboJames M. Njunge Research 22 January 2026 Article: 100 Correction: Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 更正：计算机辅助口头尸检：对比大型语言模型与医生为2019 - 2022年塞拉利昂6939例死亡分配病因的情况 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Correction 14 February 2026 Article: 99 Characteristics of parks associated with depression in women only: a cross-sectional study of 329,363 adults 仅与女性抑郁相关的公园特征：一项针对329,363名成年人的横断面研究 Jonathan R. OlsenNatalie NichollsRichard Mitchell Research 21 January 2026 Article: 98 Weight change mediates the effect of lifestyle intervention on postpartum diabetes in women with prior gestational diabetes: a secondary analysis of a randomized clinical trial 在生活方式干预对既往妊娠期糖尿病女性产后糖尿病影响中，体重变化的中介作用：一项随机临床试验的二次分析 Weiqin LiHuikun LiuGang Hu Research 21 January 2026 Article: 97 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与治疗 Global drivers of heart failure attributable to atrial fibrillation/flutter: insights fromJoinpoint regression, age-period-cohort analysis, and future projections from the GBD 2021 Study 心房颤动/扑动所致心力衰竭的全球驱动因素：来自折点回归、年龄-时期-队列分析以及2021年GBD（全球疾病负担）研究未来预测的见解 Jing ChenZhu LiGregory Y. H. Lip Research 20 January 2026 Article: 96 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Overdiagnosis of gestational diabetes mellitus during Ramadan: a retrospective population-based study in Catalonia, Spain 斋月期间妊娠期糖尿病的过度诊断：西班牙加泰罗尼亚地区一项基于人群的回顾性研究 Marta CarrascoBogdan VlachoMarta Hernández Research 20 January 2026 Article: 95 Part of 1 collection: Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Why current risk factor-based approaches fall short in predicting stillbirth: a national cohort study of nulliparous women in England 为何当前基于风险因素的方法在预测死胎方面存在不足：英格兰初产妇全国队列研究 A. HowellB. ThilaganathanTommy’s National Centre for Maternity Improvement Research 22 January 2026 Article: 94 Pay-it-forward intervention increased pneumococcal vaccine uptake among older adults in China: a randomized controlled trial 爱心传递干预措施提高了中国老年人肺炎球菌疫苗的接种率：一项随机对照试验 Jiao QinChunxing TaoBingyu Liang Research 19 January 2026 Article: 93 The impact of e-cigarette taxation: a systematic review and meta-analysis on usage, pricing strategies, and public health implications 电子烟税收的影响：针对使用情况、定价策略和公共卫生影响开展的系统综述和荟萃分析 Quan WangZheng ZhuLi Yang Research 17 January 2026 Article: 92 Safety and preliminary efficacy results of IBI389, an anti-Claudin18.2×CD3 bispecific antibody, in patients with solid tumors and gastric or gastro-esophageal tumors: a phase 1 dose escalation and expansion study 抗Claudin18.2×CD3双特异性抗体IBI389在实体瘤及胃或胃食管肿瘤患者中的安全性与初步疗效结果：一项1期剂量递增与扩展研究 Xiaoyu LiRuihong DaiFeng Bi Research 16 January 2026 Article: 91 Part of 1 collection: Clinical trials for gastrointestinal cancer 所属专题：胃肠道癌症临床试验 Comparative risk of delirium among opioid users for non-cancer pain: a retrospective cohort study 比较非癌症疼痛使用阿片类药物者发生谵妄的风险：一项回顾性队列研究 Carlos Raul Ramirez MedinaMark LuntMeghna Jani Research 31 January 2026 Article: 90 Association between preoperative interruption of antiplatelet therapy and postoperative thrombotic risk after minimally invasive surgery for abdominopelvic cancer in patients treated with P2Y12 inhibitors 接受P2Y12抑制剂治疗的患者行腹部盆腔癌症微创手术时，术前中断抗血小板治疗与术后血栓形成风险之间的关联 Masashi KubotaSatomi YoshidaKoji Kawakami Research 16 January 2026 Article: 89 Comparative outcomes of distal ureterectomy vs. radical nephroureterectomy in high-risk distal ureteral urothelial carcinoma: a two-center cohort study in Northern and Southern China 高危远端输尿管尿路上皮癌患者行远端输尿管切除术与根治性肾输尿管切除术的疗效比较：中国北方和南方两家中心的队列研究 Junyi XieZhenhua LiuWei Yu Research 16 January 2026 Article: 88 Co-occurrence patterns and related risk factors of dementia and Parkinson’s disease among older adults across 204 countries and territories: a spatial correspondence and systematic analysis 204个国家和地区老年人痴呆症与帕金森病共现模式及相关危险因素：空间对应与系统分析 Weiyang ChenMin DuJue Liu Research 15 January 2026 Article: 87 Accelerated brain aging in amyotrophic lateral sclerosis and its prognostic associations: a cohort study 肌萎缩侧索硬化症加速脑衰老及其预后关联：一项队列研究 Chenhao FangJiaoting JinShuoqiu Gan Research 15 January 2026 Article: 86 Part of 1 collection: Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 The clinical effects and cortical mechanism of rTMS in poststroke lateropulsion: a randomized controlled trial 重复经颅磁刺激（rTMS）对脑卒中后侧方倾倒的临床效果及皮质机制：一项随机对照试验 Lijiao MengRaymond C. C. TsangQuan Wei Research 14 January 2026 Article: 85 5-HT2C receptors in the glutamatergic neurons of dorsal raphe nucleus orchestrate the comorbidity of pain and anxiety in mice 中脑背侧缝际核谷氨酸能神经元中的5-HT2C受体调控小鼠疼痛与焦虑共病 Qi ZhangLi XieRiyue Jiang Research 13 January 2026 Article: 84 The clinical landscape of POLE-mutant colorectal cancer: a retrospective analysis of real-world outcome POLE突变型结直肠癌的临床现状：一项现实结局的回顾性分析 Ting XuXuhui ZhangJian Li Research 13 January 2026 Article: 83 The efficacy and safety of duloxetine in treating refractory chronic cough: a randomized clinical trial 度洛西汀治疗难治性慢性咳嗽的有效性和安全性：一项随机临床试验 Shengyuan WangHeng WuXianghuai Xu Research 13 January 2026 Article: 82 Impact of diagnosis to ablation time on clinical outcomes in patients with atrial fibrillation: post hoc analysis of the CABANA trial 心房颤动患者从诊断到消融的时间对临床预后的影响：CABANA试验的事后分析 Manlin ZhaoYang ChenGregory Y. H. Lip Research 12 January 2026 Article: 81 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Elevated maternal pre-transfer serum lipid peroxidation is associated with implantation failure and early pregnancy loss 母体转运前血清脂质过氧化水平升高与着床失败和早期流产相关 Zhangwei JiaJunxiang RenJunhao Yan Research 12 January 2026 Article: 80 Impact of Helicobacter pylori infection on gut and intratumoral microbiome and its association with immunotherapy response in gastrointestinal cancer 幽门螺杆菌感染对肠道和肿瘤内微生物组的影响及其与胃肠道癌症免疫治疗反应的关联 Keren JiaYang ChenLin Shen Research 12 January 2026 Article: 79 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物组：人类疾病的新疗法 SGLT-2 Inhibitor use and liver-related and mortality outcomes in patients with type 2 diabetes and compensated cirrhosis SGLT-2抑制剂在2型糖尿病合并代偿性肝硬化患者中的应用及其对肝脏相关预后和死亡率的影响 Tien-Shin ChouDaniel Hsiang-Te TsaiEdward Chia-Cheng Lai Research 12 January 2026 Article: 78 Extrapolating from trials to clinic: a predictive model defining the boundaries of benefit for multiple sclerosis therapies in real-world populations based on systematic review 从试验外推至临床：基于系统综述构建预测模型，界定多发性硬化症疗法在现实人群中的获益边界 Bibiana BielekovaTianxia WuMichael Calcagni Research 10 January 2026 Article: 77 A validated model for early prediction of group A streptococcal aetiology in necrotising soft tissue infections using minimal patient data 利用最少患者数据早期预测坏死性软组织感染A组链球菌病因的验证模型 Sonja KatzJaco SuijkerEdoardo Saccenti Research 10 January 2026 Article: 76 Trends in lipid-lowering therapies in acute coronary syndromes after Chinese new insurance policy: a real-world analysis 中国新医保政策实施后急性冠状动脉综合征患者降脂治疗趋势：一项现实情况分析 Xin ZhaoShujing WuJunbo Ge Research 09 January 2026 Article: 75 Fragmented healthcare and effective maternal coverage in Mexico, 2009–2023 2009-2023年墨西哥医疗体系碎片化与有效孕产妇医疗保障 Edson Serván-MoriDiego Cerecero-GarcíaOctavio Gómez-Dantés Research 09 January 2026 Article: 74 Circadian rhythm disruption in cardiovascular disease: a systematic review and meta-analysis of mechanistic evidence from animal models 昼夜节律紊乱与心血管疾病：基于动物模型机制证据的系统综述与荟萃分析 Mrinal K. DasEvi De RyckJohanna Samulin Erdem Research 09 January 2026 Article: 73 Frailty progression: The role of multimorbidity configurations in frailty transitions and predicting mortality risk among older adults 衰弱进展：多重共病组合模式在老年人衰弱状态转变及死亡风险预测中的作用 Rafael Ogaz-GonzálezQian ZouEva Corpeleijn Research 08 January 2026 Article: 72 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Effect of probiotic supplementation on the gut microbiota diversity in healthy populations: a systematic review and meta-analysis of randomised controlled trials 益生菌补充剂对健康人群肠道微生物群多样性的影响：一项针对随机对照试验的系统综述和荟萃分析 Anna Júlia ÉliásKincső Csepke Földvári-NagyLászló Földvári-Nagy Research 07 January 2026 Article: 71 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 Pain and high-impact pain in community-dwelling older adults in Australia and relation to sociodemographic and health-related factors, including physical disability, psychological distress, and quality of life 澳大利亚社区居住老年人的疼痛及重度疼痛情况，及其与社会人口统计学因素和健康相关因素（包括身体残疾、心理困扰和生活质量）的关系 Grace JoshySaman Khalatbari-SoltaniEmily Banks Research 22 January 2026 Article: 70 Mortality and morbidity burden associated with smoking: evidence from a 1.6 million cohort in Hong Kong 与吸烟相关的死亡率和发病率负担：来自香港160万人队列研究的证据 Boyuan WangTingting ChenEric Yuk Fai Wan Research 06 January 2026 Article: 69 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Association between long-term extreme high temperature and mortality: a 9-million prospective cohort study 长期极端高温与死亡率之间的关系：一项900万人的前瞻性队列研究 Bo YinQi HuangKuiying Gu Research 06 January 2026 Article: 68 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Unraveling the neurotoxic mechanisms of tranexamic acid in epilepsy induction: a network toxicology and molecular docking approach 利用网络毒理学和分子对接方法揭示氨甲环酸诱发癫痫的神经毒性机制 Tianyang ChenDalong LiuXiangYang Leng Research 03 January 2026 Article: 67 Part of 1 collection: Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study Trop2免疫正电子发射断层扫描/计算机断层扫描（PET/CT）成像在前列腺癌中的应用：一项概念验证性转化研究 Xingru LongShuxian AnDawei Jiang Research 31 December 2025 Article: 66 Methylmalonate accumulation contributes to myocardial vulnerability post-reperfusion: a novel therapeutic target and prognostic biomarker 甲基丙二酸蓄积促进再灌注后心肌脆弱性：一种新型治疗靶点和预后生物标志物 Shanjie WangJunChen GuoShaohong Fang Research 31 December 2025 Article: 65 Prophylactic effect of intraoperative sodium oxybate on postoperative delirium in older patients undergoing major orthopedic surgery: a randomized clinical trial 术中羟丁酸钠对接受大型骨科手术的老年患者术后谵妄的预防作用：一项随机临床试验 Meiying CuiHang XuePing Zhao Research 31 December 2025 Article: 64 Part of 1 collection:Psychoactives: Recreational drugs repurposed as novel therapies 所属专题：精神活性物质：将娱乐性药物重新用于新型疗法 Prevalence of hysterectomy in urban China and associations between metabolic disorders and hysterectomy: a multicenter population-based study involving over 9 million women 中国城市子宫切除术的流行情况以及代谢紊乱与子宫切除术之间的关系：一项涉及超过900万女性的多中心人群基础研究 Yanrui BiYuan MaYing Gao Research 30 December 2025 Article: 63 Sex differences in cardiac risk and kidney function: serum creatinine versus cystatin C 心脏风险和肾功能方面的性别差异：血清肌酐与胱抑素C的对比 Nicole L. De La MataJames A. HedleyJennifer S. Lees Research 30 December 2025 Article: 62 The association of post-conization pregnancy with subsequent cervical lesions: evidence from a nationwide cohort in Sweden 锥切术后妊娠与后续宫颈病变的关联：来自瑞典全国队列研究的证据 Huan YiJimiao HuangJianguang Ji Research 29 December 2025 Article: 61 Tibial periosteal distraction for ischemic leg ulcers: animal and clinical cohort study 胫骨骨膜牵张术治疗缺血性下肢溃疡：动物及临床队列研究 Peilin ZhouWenqiang WangQikai Hua Research 28 December 2025 Article: 60 Preoperative conversion therapy of camrelizumab combined with paclitaxel and nedaplatin for unresectable advanced esophageal squamous cell carcinoma: a phase 2 study 卡瑞利珠单抗联合紫杉醇和奈达铂对不可切除的晚期食管鳞癌的术前转化治疗：一项2期研究 Jinhong ZhuJinfeng ZhangJianqun Ma Research 28 December 2025 Article: 59 Clustering of cardiometabolic risk factors, physical activity, digital exclusion, and depressive symptoms trajectories in adults aged 50years and older: findings from two prospective cohort studies 50岁及以上成年人心血管代谢风险因素聚集、身体活动、数字排斥及抑郁症状轨迹：两项前瞻性队列研究的发现 Xiaosheng DongJiaqiang XiaoChengchao Zhou Research 28 December 2025 Article: 58 Eligibility of real-world patients for aspirin primary prevention trials in cardiovascular disease 现实中符合心血管疾病阿司匹林一级预防试验资格的患者情况 Michael HolderDaniel R. MoralesBruce Guthrie Research 27 January 2026 Article: 57 Polygenic risk score-guided personalized osteoporosis screening: a population-based study 基于多基因风险评分指导的个性化骨质疏松症筛查：一项基于人群的研究 Dongxue WangWen SunJianguang Ji Research 14 January 2026 Article: 56 Urea cycle modulation by combined SGLT2 inhibitors and metformin SGLT2抑制剂与二甲双胍联合用药对尿素循环的调节作用 Makoto HaradaJonathan AdamRui Wang-Sattler Research 08 January 2026 Article: 55 Safety and neuroprotective efficacy of the VCP inhibitor ML240 in large-animal and human retinal explants: a preclinical ex vivo study VCP抑制剂ML240在大型动物及人视网膜外植体中的安全性和神经保护功效：一项临床前离体研究 Ana-Cristina Almansa-GarcíaAngela ArmentoBlanca Arango-Gonzalez Research 10 January 2026 Article: 54 Impact of an eight-week isocaloric vegan dietary intervention on hemogram parameters and lymphocyte subsets: a randomized-controlled trial 为期八周的等热量纯素饮食干预对血细胞参数和淋巴细胞亚群的影响：一项随机对照试验 Julian HerterFrieda StübingMaximilian Andreas Storz Research 10 January 2026 Article: 53 Association between psychosocial factors and adverse effects of light-to-moderate ambient heat in patients with chronic diseases: results of the prospective cohort study CLIMATE-II 社会心理因素与轻至中度环境热对慢性病患者不良影响之间的关联：前瞻性队列研究CLIMATE-II的结果 Ingmar SchäferValentina PauckeDagmar Lühmann Research 15 January 2026 Article: 52 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Maternal infection during pregnancy and the risk of childhood cancer: a systematic review and meta-analysis 孕期母体感染与儿童期患癌风险：一项系统综述和荟萃分析 Loviisa MulanjeLara Kim BrackmannRajini Nagrani Research 14 January 2026 Article: 51 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Supplementary biomarker testing in molecular tumor boards increases actionable therapy recommendations: a prospective real-world study of 658 patients 分子肿瘤委员会中的补充生物标志物检测增加了可采取治疗措施的建议：一项针对658例患者的前瞻性真实世界研究 Alexander ScheiterSimon MellinKirsten Utpatel Research 14 January 2026 Article: 50 Computer assisted verbal autopsy: comparing large language models to physicians for assigning causes to 6939 deaths in Sierra Leone from 2019–2022 计算机辅助口头尸检：对比大型语言模型与医生对塞拉利昂2019 - 2022年6939例死亡原因的判定 Richard WenAnteneh Tesfaye AssalifRashid Ansumana Research 24 December 2025 Article: 49 Loss of Y chromosome and its implications in male amyotrophic lateral sclerosis: insights from the UK Biobank Y染色体缺失及其在男性肌萎缩侧索硬化症中的影响：来自英国生物银行的研究见解 Wei-Ming SuQing-Qing DuanYong-Ping Chen Research 24 December 2025 Article: 48 Part of 1 collection:Amyotrophic lateral sclerosis: latest advances and novel updates 所属专题：肌萎缩侧索硬化症：最新进展与新动态 Prenatal lipopolysaccharide exposure programs the early-life lung development by modulating mesenchymal fibroblasts in a time- and dose-dependent manner 产前脂多糖暴露通过调节间充质成纤维细胞以时间和剂量依赖性方式来影响早期肺部发育 Ying DongStefan HadzicSaverio Bellusci Research 22 December 2025 Article: 47 Life course socioeconomic trajectories and chronic disease risk in later life among 30,055 older adults across 27 European countries (the SHARE study) 27个欧洲国家30,055名老年人生命历程中的社会经济轨迹与晚年慢性疾病风险（基于SHARE研究） Taymara C. AbreuJoline W. J. BeulensJoreintje D. Mackenbach Research 20 December 2025 Article: 46 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Validation of a novel patient-reported measure of the burden of digital care in diabetes 由糖尿病患者报告的数字化护理负担新型测评工具的验证 Misk Al ZahidyJennifer L. RidgewayVictor M. Montori Research 20 December 2025 Article: 45 Determinants of long-term SARS-CoV-2 immune responses in asymptomatic-to-moderate COVID-19 patients in sub-Saharan Africa 撒哈拉以南非洲地区无症状至中度 COVID-19 患者长期 SARS-CoV-2 免疫应答的决定因素 Víctor L. de RiojaOdin GoovaertsGemma Moncunill Research 14 January 2026 Article: 44 Camrelizumab and apatinib in Chinese patients with locally advanced or metastatic radioiodine-refractory differentiated thyroid cancer: an exploratory open-label, single-arm trial 卡瑞利珠单抗联合阿帕替尼治疗中国局灶性晚期或转移性放射性碘难治性分化型甲状腺癌：一项探索性开放标签单臂试验 Xin ZhangDi SunYansong Lin Research 18 December 2025 Article: 43 Urinary polyphenol signature of the Mediterranean diet is associated with lower cardiovascular disease risk: the PREDIMED trial 地中海饮食的尿液多酚特征与心血管疾病风险较低相关：PREDIMED 试验 Inés Domínguez-LópezPolina GalkinaRosa M. Lamuela-Raventós Research 18 December 2025 Article: 42 Meta-analysis and external validation of a risk model for gastrointestinal bleeding after percutaneous coronary intervention 经皮冠状动脉介入治疗后胃肠道出血风险模型的荟萃分析及外部验证 Hualong MaCong PengQiaohong Yang Research 18 December 2025 Article: 41 DNA methylation-based clocks, tobacco smoking, and lung cancer risk 基于DNA甲基化的生物钟、烟草吸烟与肺癌风险 Ricardo Cortez Cardoso PenhaJustina Ucheojor OnwukaMattias Johansson Research 17 December 2025 Article: 40 Part of 1 collection:Carcinogens and human health 所属专题：致癌物与人类健康 Risk and protective factors associated with brain grey matter patterns in a population-based cohort of cognitively unimpaired 70years old 认知功能未受损的70岁老年人基于人口的队列中，与大脑灰质模式相关的风险和保护因素 Giulia LorenzonAnna MarsegliaEric Westman Research 17 December 2025 Article: 39 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学和风险因素的作用 Street view-derived city built environment and vulnerability to temperature extremes: a nationally representative population-based cohort study 基于街景图像的城市建成环境与极端温度脆弱性：一项全国代表性人口队列研究 Wanzhou WangChao YangLuxia Zhang Research 16 December 2025 Article: 38 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 A booster dose of an inactivated SARS-CoV-2 vaccine targeting virus variants sustains protective humoral and cellular immunity 针对病毒变异株的灭活严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）疫苗加强针可维持保护性体液免疫和细胞免疫 Constanza MéndezLinmar Rodríguez-GuilarteSusan M. Bueno Research 15 December 2025 Article: 37 Dapagliflozin alleviates sunitinib-induced cardiotoxicity through AMPKα-PPARα axis and enhances the sensitivity of renal cell carcinoma to sunitinib 达格列净通过AMPKα-PPARα轴减轻舒尼替尼诱导的心脏毒性，并增强肾细胞癌对舒尼替尼的敏感性 Shi-yu HuangMin HuLei Wang Research 15 December 2025 Article: 36 Network dysfunction underlying verbal fluency deficits in newly diagnosed epilepsy: a resting-state fMRI functional connectivity study 新诊断癫痫患者言语流畅性缺陷背后的网络功能障碍：一项静息态功能磁共振成像功能连接研究 Fangzhou LiuPing JiangLing Liu Research 13 December 2025 Article: 35 Part of 1 collection:Epilepsy: Seizure prevention, treatment, and epidemiology 所属专题：癫痫：癫痫发作的预防、治疗和流行病学 Long-term quality of life in non-epithelial ovarian cancer survivors: TMRG-GINECO-Vivrovaire rare tumors case–control study 基于广西新生儿地中海贫血基因组图谱计划开展的家庭三联体/四联体分析 Coraline DubotIsabelle Ray-CoquardFlorence Joly Research 12 December 2025 Article: 34 Family trios/quartets analysis based on the Newborn Genomic Atlas for Thalassemia project in Guangxi 非上皮性卵巢癌幸存者的长期生活质量：TMRG-GINECO-Vivrovaire罕见肿瘤病例对照研究 Wei WeiChunrong GuiBaoheng Gui Research 12 December 2025 Article: 33 Hyperuricemic persons use more analgesics than normouricemic—is asymptomatic hyperuricemia really asymptomatic? 高尿酸血症患者比血尿酸正常者使用更多镇痛药——无症状性高尿酸血症真的“无症状”吗？ Janis TimsansJenni Emilia KauppiMarkku Kauppi Research 11 December 2025 Article: 32 Social isolation, loneliness, and multi-system medical conditions: phenome-wide association and disease-trajectory analyses 社会孤立、孤独感与多系统医学病症：全表型组关联分析及疾病轨迹研究 Tingshan DuanZhi CaoChenjie Xu Research 10 December 2025 Article: 31 Digital marketing techniques within online food retail platforms: a scoping review 在线食品零售平台中的数字营销技巧：一项范围综述 Adyya GuptaCatherine E. HugginsAnna Peeters Research 10 December 2025 Article: 30 Dramatic increases in redundant publications in the Generative AI era 生成式人工智能时代冗余出版物数量急剧增加 Danny MaupinTulsi SuchakMatt Spick Research 09 December 2025 Article: 29 Cardiovascular risk burden and guideline-recommended lipid and blood pressure goals in an Italian Cohort: findings from the HUMTELEMED web-based platform 意大利人群心血管风险负担及指南推荐的血脂和血压目标达成情况：HUMTELEMED网络平台的发现 Matteo LandolfoAlessandro GezziRiccardo Sarzani Research 09 December 2025 Article: 28 Part of 1 collection:Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Efficacy and safety of Janus kinase 1/2 inhibitor KL130008 in active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase II trial Janus激酶1/2抑制剂KL130008治疗活动性类风湿关节炎的有效性和安全性：一项随机、双盲、安慰剂对照的II期试验 Yue ChengHonghu TangYi Liu Research 09 December 2025 Article: 27 Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants 子宫内膜癌的风险分层：英国生物银行129,829名参与者中多基因风险评分和体重指数的独立及联合效应 Xuemin WangLaure DossusTracy A. O’Mara Research 10 February 2026 Article: 26 Maternal probiotics intake during pregnancy and exclusive colostrum breastfeeding are associated with a reduced risk of neonatal jaundice 孕期摄入益生菌及纯母乳喂养初乳与新生儿黄疸风险降低相关 Bekalu Kassie AlemuChi Chiu WangYao Wang Research 08 December 2025 Article: 25 Hepatic steatosis in postmenopausal women is characterized by distinct serum extracellular vesicle proteomic signatures 绝经后女性脂肪肝具有独特的血清细胞外囊泡蛋白质组特征 Patrick PirrotteBrooke LovellJohanna K. DiStefano Research 07 December 2025 Article: 24 Global, regional, and national temporal trends in the prevalence of environmental heat and cold exposure among older adults aged 60–99 years, 1990–2021: an age-period-cohort analysis based on the Global Burden of Disease Study 2021 基于2021年全球疾病负担研究，对1990 - 2021年60 - 99岁老年人环境热暴露和冷暴露患病率的全球、区域和国家时间趋势分析：一项基于年龄 - 时期 - 队列模型的分析 Shenghao XuJing WangJianlin Xiao Research 07 December 2025 Article: 23 Part of 1 collection:Climate change and human health 所属专题：气候变化与人类健康 Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models 亲环蛋白B缺乏可增强心肌能量合成，并在临床前模型中预防心力衰竭 Xiao ZongXierenayi TudiRong Tao Research 07 December 2025 Article: 22 Part of 1 collection:Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 Normobaric hyperoxia for intracerebral hemorrhage: a randomized clinical trial 常压高氧治疗脑出血：一项随机临床试验 Zhiying ChenJiayue DingRan Meng Research 07 December 2025 Article: 21 Nationwide trends in pediatric hospitalizations for eating disorders in France between 2013 and 2022: a retrospective study using the national health insurance database Emmanuelle LogeaisFrançoise TroussierLilia Khendek 2013 - 2022年法国因进食障碍住院的儿科患者全国趋势：一项使用国家健康保险数据库的回顾性研究 Research 05 December 2025 Article: 20 Part of 1 collection:Child and adolescent psychiatry 所属专题：儿童与青少年精神病学 Self-management of vaginal pessaries for pelvic organ prolapse: multi-method process evaluation, linked to the TOPSY randomised controlled trial 盆腔器官脱垂阴道子宫托自我管理：与TOPSY随机对照试验相关的多方法过程评估 Carol BuggeMelanie Dembinskythe TOPSY team Research 05 December 2025 Article: 19 Large-scale plasma proteomics reveals bidirectional associations between sleep patterns and inflammatory bowel disease: a prospective cohort study 大规模血浆蛋白质组学研究揭示睡眠模式与炎症性肠病之间的双向关联：一项前瞻性队列研究 Kaixing LeYaru LiuZhigang Liu Research 05 December 2025 Article: 18 Association between socioeconomic status and diabetic retinopathy in individuals with type 1 diabetes: a systematic review and meta-analysis 1型糖尿病患者社会经济地位与糖尿病视网膜病变之间的关联：一项系统综述和荟萃分析 Fernando Sebastian-VallesSergio Núñez de Arenas-ArroyoJulia Martínez-Alfonso Review 05 December 2025 Article: 17 Patterns of disparity: age and socioeconomic differences in women’s smoking and quitting outcomes in Great Britain 差异模式：英国女性吸烟及戒烟结局的年龄和社会经济差异 Sarah E. JacksonCaitlin NotleySharon Cox Research 10 February 2026 Article: 16 Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression SWI/SNF复合体中的基因组致病性改变通过下调STING表达损害中国KRAS突变型非小细胞肺癌患者的免疫治疗效果 Lingling GaoJie JiangXuchao Zhang Research 03 December 2025 Article: 15 Residential radon exposure and incident myocardial infarction and stroke risks in the All of Us Research Program “我们所有人”研究项目中住宅氡暴露与心肌梗死和卒中发病风险的关系 Jiajun LuoZhihao JinBriseis Aschebrook-Kilfoy Research 03 December 2025 Article: 14 Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) diet and cardiovascular disease and arrhythmias 用于延缓神经退行性变的地中海饮食-终止高血压膳食疗法干预措施（MIND）与心血管疾病及心律失常的关系 Pei QinFrederick K. HoJill P. Pell Research02 December 2025 Article: 13 Part of 1 collection: Cardiomyopathy and cardiac arrhythmias 所属专题：心肌病与心律失常 KoMethylNet: a novel epigenetic clock based on neural network analysis of DNA methylation data and epigenetic age acceleration in a Korean population KoMethylNet：基于神经网络分析DNA甲基化数据的新型表观遗传时钟及韩国人群的表观遗传年龄加速研究 Dabin YunKwangyeon OhNan Song Research 03 December 2025 Article: 12 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学及风险因素的作用 Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants 睡眠与体力活动的权衡与痴呆风险：英国生物样本库参与者的一项前瞻性队列研究 Stephanie YiallourouLachlan CribbMatthew P. Pase Research 03 December 2025 Article: 11 Part of 1 collection: Sleep and mental health 所属专题：睡眠与心理健康 Integration of gut microbiome and lipid metabolism reveals the anti-cancer effects of pentadecanoic acid on bladder cancer 肠道微生物组与脂质代谢的整合揭示十五烷酸对膀胱癌的抗癌作用 Ya-Ting ChenJing SuiEvan Yi-Wen Yu Research 03 December 2025 Article: 10 Part of 1 collection: Gut microbiota: New treatments of human disease 所属专题：肠道微生物群：人类疾病的新疗法 A social determinants-based county-level cardiovascular mortality index to identify high-risk counties in the USA 基于社会决定因素的美国县级心血管疾病死亡率指数，用于识别高风险县 Anqi ZhuBibhas ChakrabortyTazeen H. Jafar Research 02 December 2025 Article: 9 HIV infection and immunosenescence: challenges and intervention strategies HIV感染与免疫衰老：挑战与干预策略 Junyan JinQianqian XuBin Su Review 02 December 2025 Article: 8 Part of 1 collection: Healthy aging and longevity: the role of preventive medicine and risk factors 所属专题：健康老龄化与长寿：预防医学与风险因素的作用 Machine learning-based prediction of short-term outcomes in aneurysmal subarachnoid hemorrhage: a multicenter study integrating clinical and inflammatory indicators 基于机器学习的动脉瘤性蛛网膜下腔出血短期预后预测：一项整合临床与炎症指标的多中心研究 Weichong ZhouCong PengHui Shi Research 29 November 2025 Article: 7 The effectiveness and safety of a mobile application-based self-regulation intervention to support weight loss among adults living with obesity: a large-scale pragmatic randomised controlled trial 基于移动应用程序的自我调节干预措施在支持肥胖成年人减重方面的有效性与安全性：一项大规模实用性随机对照试验 Paul DoodyGina M. WrenPaul Aveyard Research 29 November 2025 Article: 6 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响 Adiposity and the first-onset of diagnosed mental illnesses: a population-based cohort study of 10 million UK adults 脂肪堆积（肥胖程度）与首次确诊精神疾病的关系：一项基于1000万英国成年人的队列研究 Xue DongPaul AveyardMin Gao Research 29 November 2025 Article: 5 Efficacy of standard care versus acoustic therapy on acute tinnitus in idiopathic sudden sensorineural hearing loss: a randomized controlled trial 标准治疗与声治疗对特发性突发性感音神经性听力损失伴急性耳鸣的疗效对比：一项随机对照试验 Xinyi WangKe QiuYu Zhao Research 28 November 2025 Article: 4 Trends and socio-economic inequalities in overweight- and obesity-related premature cardiovascular disease mortality in Australia 澳大利亚超重与肥胖相关过早心血管疾病死亡的趋势及社会经济不平等状况 Tim Adair Research 29 January 2026 Article: 3 Assessing the impact of maternal blood pressure during pregnancy on perinatal health: a wide-angled Mendelian randomization study 评估孕期母体血压对围产期健康的影响：一项广角孟德尔随机化研究 Fernanda Morales-BersteinAna Gonçalves-SoaresMaria-Carolina Borges Research 14 January 2026 Article: 2 Part of 1 collection:Diagnosis and management of gestational diabetes 所属专题：妊娠期糖尿病的诊断与管理 Prevalence of use and interest in using glucagon-like peptide-1 receptor agonists for weight loss: a population study in Great Britain 胰高血糖素样肽-1受体激动剂用于减重的使用率及使用意愿：一项针对英国人群的研究 Sarah E. JacksonJamie BrownLion Shahab Research 08 January 2026 Article: 1 Part of 1 collection: Weight loss interventions and their health impacts 所属专题：减重干预措施及其对健康的影响

2026-07-22

·皮科Online

化脓性汗腺炎生物制剂及分子靶向治疗研究进展

化脓性汗腺炎（hidradenitis suppurativa，HS）又名反常性痤疮(acne inversa，AI)，是一种慢性、反复发作的毛囊炎症性皮肤病，主要表现为腋窝、腹股沟、乳下及肛周等部位反复出现疼痛性结节、脓肿、窦道及瘢痕。近年来研究发现，TNF-α、IL-17、IL-1等炎症通路参与HS的发生发展，针对这些靶点的生物制剂和分子靶向药物不断取得新的临床证据。本文结合最新研究，梳理目前HS及其共病的生物制剂和分子靶向药物研究进展，为临床治疗提供参考。生物制剂目前，阿达木单抗仍是HS应用最广泛的生物制剂，其次为英夫利昔单抗、司库奇尤单抗、乌司奴单抗及古塞奇尤单抗。研究显示，联合手术可延长生物制剂治疗时间，停药最主要原因仍是疗效不足，其次为不良反应。红细胞沉降率、C反应蛋白、IL-6、皮肤超声窦道数量及相关细胞因子水平，可作为疾病活动度评估及靶点选择的重要参考。 1 TNF-α及其受体抑制剂阿达木单抗（adalimumab）首个获FDA及EMA批准用于HS治疗的生物制剂，也是目前临床证据最充分、应用最广泛的TNF-α抑制剂。Ⅲ期临床研究显示，治疗12周即可起效，36周约56%的患者达到HiSCR，部分患者疗效可维持3年以上。推荐方案：每2周80mg（52.58%），其次为每周40mg（38.2%），疗效不足时可适当增加剂量。联合手术治疗可进一步改善疾病严重程度及生活质量，且术前通常无需停药不良反应：感染、鼻咽炎、HS加重；少见银屑病、恶性肿瘤及严重不良事件。英夫利昔单抗（infliximab）是目前HS治疗中中位用药时间最长的TNF-α抑制剂。Meta分析显示，中重度HS总体缓解率约83%，高频、高剂量方案可进一步提高疗效。推荐方案：起始7.5mg/kg，每4周1次；必要时可增加至10mg/kg。不良反应：非严重感染、输液反应；少数患者可出现败血症、肺结核、过敏性休克及多发性关节炎。其他依那西普（etanercept）：总体应答率仅约20%，且近年来缺乏新的临床证据，目前已较少用于HS治疗。 2 IL-17及其受体抑制剂司库奇尤单抗（sikuximab）第二个获EMA批准用于HS治疗的生物制剂。Ⅲ期SUNSHINE和SUNRISE研究显示，58%～62%的患者达到HiSCR，疗效可持续52周，即使既往使用过生物制剂仍可获益。推荐方案：每次300mg，每4周1次；必要时可缩短至2～3周。不良反应：口腔念珠菌病、关节炎、头痛、注射部位疼痛、炎症性肠病活动等。比奇珠单抗（bimekizumab）同时靶向IL-17A和IL-17F，是2024年EMA批准用于HS治疗的新型生物制剂。Ⅲ期研究显示，治疗48周后77%～82%的患者达到HiSCR50，59%～71%达到HiSCR75，对炎性结节和窦道均有改善。推荐方案：每4周320mg。不良反应：腹泻、口腔念珠菌病、头痛等；需警惕严重感染、粒细胞减少、炎症性肠病及精神相关不良事件。其他依奇珠单抗(ixekizumab)：仅有个案报道其对HS有效。布罗达单抗（brodalumab）：目前小样本研究显示，患者治疗12周均达到HiSCR，缩短给药间隔可减少窦道及疼痛复发。2024年回顾性研究显示，约50%的患者达到HiSCR，不良反应发生率约32.25%，主要包括注射部位疼痛、食欲减退、多发性关节炎、上呼吸道感染及口腔溃疡。 3 IL-12/IL-23抑制剂乌司奴单抗（ulsunumab） Meta分析显示，总体有效率约67%，但目前仍缺乏高质量随机对照研究支持。对于严重HS患者，可适当缩短给药间隔，但获益仍需进一步验证。推荐方案：一般给药剂量为90mg，间隔8～12周给药，对于严重HS患者可考虑将间隔时间缩短至4周，但获益尚不确切。不良反应：发生率约4.5%，包括头痛、疲劳、上呼吸道感染、荨麻疹、膀胱炎、银屑病样皮炎、关节炎、腋窝细菌感染及复发性感染。古塞奇尤单抗（guselkumab） Ⅱ期研究未显示较安慰剂具有显著优势，目前仅有部分个案提示可能对HS有效，证据仍较有限。 4 IL-1及其受体抑制剂贝迈奇单抗（bermekimab） Ⅱ期研究显示，约61%～63%的患者达到HiSCR，但由于缺乏安慰剂对照，其疗效仍需进一步验证。不良反应：眼部充血、胃肠道功能紊乱、注射部位反应、乏力、感染、低血糖、肌肉痉挛和疼痛、头痛、颅内压增高、晕厥、脑出血、痛经、汗腺炎、皮疹及高血压（hypertension）。卡那单抗（canakinumab）目前仅有个案报道其对HS的疗效。阿那白滞素（anakinra）随机对照研究显示，12周时78%的患者达到HiSCR，但近年来缺乏新的临床研究报道。不良反应：腹泻、注射部位肿胀及念珠菌性阴道炎。 5 IL-36受体拮抗剂佩索利单抗（spesolimab）随机对照研究显示，治疗12周后31%的患者达到HiSCR50，较安慰剂组更高，且对窦道改善尤为明显。 6 C5a抑制剂韦洛利单抗（vilobelimab）小型开放研究显示，治疗50天后75%的患者达到HiSCR，3个月总体应答率达83%，对窦道改善较明显，目前Ⅱ期临床研究仍在进行中。分子靶向药 1 JAK通路抑制剂波伏西替尼（povorcitinib）口服JAK1选择性抑制剂，Ⅱ期研究显示，不同剂量均可改善HS症状，第16周最高约48%的患者达到HiSCR，不同剂量总体安全性良好。乌帕替尼（upadacitinib）口服JAK1选择性抑制剂，研究显示，所有患者均达到HiSCR50，75%的患者达到HiSCR75，疗效可维持24周。 2 其他 HSP90抑制剂 RGRN-305可显著改善HS炎性结节，第16周HiSCR50达到60%，较安慰剂提高40%。 PDE抑制剂阿普司特可改善轻中度HS，研究中第2周70%的患者达到HiSCR，第16周仍有50%的患者维持疗效，长期随访显示多数患者疗效可持续。 HS及其共病药物选择 HS常伴发代谢性疾病、自身免疫性疾病、精神疾病及其他系统性疾病，因此，选择生物制剂或分子靶向药物时，不仅应关注其对皮肤病变的疗效，还应综合评估患者共病情况及药物安全性，实现个体化治疗。 1 HS合并代谢性疾病 HS患者发生肥胖、糖尿病、高血压、血脂异常及心脑血管疾病的风险较高。现有研究显示，大多数生物制剂总体安全性良好，但部分药物存在心血管相关不良事件的个案报道，因此，对于合并代谢综合征或心血管疾病高风险患者，应结合基础疾病情况综合选择治疗方案，并加强随访监测。 2 HS合并免疫性疾病 HS常与炎症性肠病、银屑病、银屑病关节炎、脊柱关节炎及其他自身免疫性疾病共存。TNF-α抑制剂、IL-17抑制剂及IL-23抑制剂在不同免疫性共病中的治疗优势存在差异，同时也可能增加感染或诱发免疫相关不良反应。因此，应根据患者的共病类型、既往治疗史及安全性综合制定个体化治疗方案。 3 HS合并精神疾病 Meta分析显示，HS患者抑郁患病率约16.9%，焦虑患病率约4.9%。随着皮损控制，部分患者生活质量和心理状态可得到改善。但个别生物制剂曾报道与抑郁或自杀倾向相关，因此，治疗前应充分评估患者精神状态，并在治疗过程中持续关注心理健康。 4 HS合并血液系统疾病部分生物制剂可能影响血液学指标，如比奇珠单抗治疗期间需关注粒细胞减少等不良反应；而阿达木单抗在部分合并贫血患者中可能有助于改善贫血状态。因此，治疗过程中应结合实验室检查进行动态监测。 5 HS合并慢性肾病目前关于HS合并慢性肾病患者应用生物制剂的研究仍较少。已有个案报道显示，司库奇尤单抗和卡那单抗在部分患者中取得了较好的疗效和安全性，但仍需更多临床证据进一步验证。结语近年来，HS生物制剂及分子靶向药物不断取得新进展，TNF-α和IL-17抑制剂已成为目前证据最充分的治疗选择，IL-36受体、C5a、JAK、HSP90等新兴靶点也展现出良好的应用前景。未来，随着更多高质量临床研究和真实世界证据积累，HS治疗将进一步向精准化、个体化方向发展。对于合并代谢、免疫及精神等共病患者，仍需综合疗效、安全性及共病特点，制定更加个体化的治疗策略。参考文献： [1]徐心怡,赵茜,莫小辉,等.生物制剂及分子靶向药物治疗化脓性汗腺炎及其共病的临床研究进展[J].世界临床药物,2025,46(9):869-877.DOI:10.13683/j.wph.2025.09.001. [2]WANG ZS,LI J,JU Q,et al.Prevalence of acne inversa（hidradenitis suppurativa）in China:a nationwide cross-sectional epidemiological study[J].Int J Dermatol Venereol,2022,5（1）:1-7. [3]SAUNTE DML,JEMEC GBE.Hidradenitis suppurativa:advances in diagnosis and treatment[J].J Am Med Assoc,2017,318（20）:2019-2032. [4]G O L D B U R G S R,S T R O B E R B E,PAY E T T E M J.Hidradenitis suppurativa:epidemiology,clinical presentation,and pathogenesis[J].J Am Acad Dermatol,2020,82（5）:1045-1058. [5]王慧,黄贺,张学军,等.生物制剂在化脓性汗腺炎治疗中的应用进展[J].中国皮肤性病学杂志,2022,36（2）:218-221. 推荐阅读原发性手汗症阶梯化诊疗全方案，皮肤科一线实操指南别只看淡斑效果！氨甲环酸不良反应要注意皮秒激光联合药物治疗黄褐斑临床应用进展声明：皮科在线原创内容版权均属皮科在线所有。转载文章或“皮科在线”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场。授权转载时须注明来源。如果存在侵权、或不希望被转载的媒体或个人可与我们联系进行删除处理。

临床3期临床结果临床成功临床失败

100 项与氨甲环酸相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
D01136	氨甲环酸	B02AA02	DB00302

研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
凝血障碍	澳大利亚	Pfizer Australia Pty Ltd.	1991-09-05
遗传性血管性水肿	澳大利亚	Pfizer Australia Pty Ltd.	1991-09-05
前房出血	澳大利亚	Pfizer Australia Pty Ltd.	1991-09-05
月经过多	澳大利亚	Pfizer Australia Pty Ltd.	1991-09-05
血友病	美国	Pharmacia & Upjohn, Inc.	1986-12-30
血友病	美国	Pfizer Inc.	1986-12-30
红斑	日本	Nipro Pharma Corp.	1969-01-16
瘙痒	日本	Nipro Pharma Corp.	1969-01-16
肿胀	日本	Nipro Pharma Corp.	1969-01-16
药物性皮炎	日本	Daiichi Sankyo Co., Ltd.	1965-08-31
出血	日本	Daiichi Sankyo Co., Ltd.	1965-08-31
咽喉炎	日本	Daiichi Sankyo Co., Ltd.	1965-08-31
口腔炎	日本	Daiichi Sankyo Co., Ltd.	1965-08-31
扁桃体炎	日本	Daiichi Sankyo Co., Ltd.	1965-08-31
荨麻疹	日本	Daiichi Sankyo Co., Ltd.	1965-08-31

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
口腔出血	临床3期	美国	Hyloris Developments SA	2023-11-07
口腔出血	临床3期	克罗地亚	Hyloris Developments SA	2023-11-07
口腔出血	临床3期	匈牙利	Hyloris Developments SA	2023-11-07
口腔出血	临床3期	罗马尼亚	Hyloris Developments SA	2023-11-07
口腔出血	临床3期	西班牙	Hyloris Developments SA	2023-11-07
肠道疾病	临床3期	中国	恒翼生物医药（上海）股份有限公司	2023-03-27
肠阻塞	临床3期	美国	Palisade Bio, Inc.	2022-06-28
胃肠功能紊乱	临床3期	中国	恒翼生物医药（上海）股份有限公司	2022-01-30
脑出血	临床3期	尼泊尔	-	2021-02-08
血肿	临床3期	尼泊尔	-	2021-02-08

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临床结果

适应症

分期

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03923959 (Pubmed \| J Orthop Trauma)	临床3期	髋部骨折	283	Tranexamic acid	簾齋獵齋餘餘築憲襯鏇(蓋艱製積糧範淵鏇遞衊): P-Value = 0.183 更多	不佳	2026-07-01
				Placebo
NCT04803747 (TRACTION, Pubmed \| N Engl J Med)	临床4期	-	8,273	Tranexamic acid	顧積鑰鹹鬱襯獵製憲糧(鑰醖積網壓範憲鹽觸夢) = 糧齋選鑰觸製壓網觸齋鏇齋網鹽繭網製繭簾襯 (繭衊築鹽蓋簾膚鏇顧繭 ) 更多	积极	2026-06-25
				Placebo	顧積鑰鹹鬱襯獵製憲糧(鑰醖積網壓範憲鹽觸夢) = 窪廠壓憲獵遞顧糧淵簾鏇齋網鹽繭網製繭簾襯 (繭衊築鹽蓋簾膚鏇顧繭 ) 更多
NCT05474027 (CTgov)	临床4期	手术失血 \| 低血压	115	Avoidance of Deliberate Hypotensive Anesthesia+TRANEXAMIC ACID 1 G in 10 mL INTRAVENOUS INJECTION, SOLUTION	鹹範築構鏇繭簾製遞築(夢齋膚顧廠簾顧夢淵衊) = 獵築築選繭餘窪襯衊簾憲選鬱獵憲築餘製醖壓 (憲襯壓構窪鹹鏇鬱窪構, 0.5) 更多	-	2026-05-27
NCT05811676 (Pubmed \| BMJ)	临床3期	前置胎盘	1,694	Tranexamic acid + prophylactic oxytocin	構壓齋餘網糧鹹選膚顧(窪繭鏇艱艱鬱製遞簾願) = 鹹遞鬱顧蓋鏇蓋衊獵餘廠艱願遞淵網窪憲淵糧 (齋選膚醖艱蓋製醖餘鹽 ) 更多	积极	2026-05-13
				Placebo + prophylactic oxytocin	構壓齋餘網糧鹹選膚顧(窪繭鏇艱艱鬱製遞簾願) = 壓繭窪鏇廠艱網製網鏇廠艱願遞淵網窪憲淵糧 (齋選膚醖艱蓋製醖餘鹽 ) 更多
EHA2026	N/A	冯·维勒布兰德病	410	Tranexamic acid	觸選製觸範鹹膚構範襯(衊蓋構餘鑰憲鑰艱膚齋) = 獵蓋鹹夢壓鑰觸壓憲顧餘窪鏇鏇淵簾積鬱壓遞 (遞構觸鹽衊製獵範蓋鏇 ) 更多	积极	2026-05-12
NCT07261930 (Pubmed \| BMC Musculoskelet Disord)	临床4期	-	43	Tranexamic acid	鏇鬱艱醖糧鏇齋築膚憲(鏇鑰簾鹹齋壓膚願廠壓) = 鏇鹽醖鏇襯艱製膚遞鹹顧襯衊艱繭鑰繭鏇齋繭 (衊壓製淵願憲廠廠餘鹹 ) 更多	积极	2026-04-14
NCT03540368 (CTgov)	N/A	上消化道出血 \| 消化道出血	48	Placebo	蓋築築願積積鹽積憲齋 = 憲遞糧艱積夢獵窪繭醖選餘糧顧壓餘鹹夢襯窪 (夢獵餘夢壓選衊網願觸, 衊積繭憲繭選壓窪艱夢 ~ 顧獵獵獵遞觸構鹹壓淵) 更多	-	2026-03-27
NCT05397652 (CTgov)	临床4期	出血 \| 手术失血 \| 肩袖损伤	121	Tranexamic Acid Injectable Product (Tranexamic Acid Injectable Product)	窪鑰簾網窪選顧廠廠選(鹹積鑰範廠鑰蓋襯獵製) = 範製遞獵顧鏇製鏇鹽鬱衊齋構繭壓蓋壓夢淵獵 (蓋構餘願壓積構膚齋鹽, 0.82) 更多	-	2026-02-24
				Placebo (Placebo)	窪鑰簾網窪選顧廠廠選(鹹積鑰範廠鑰蓋襯獵製) = 餘鏇夢襯憲觸構夢膚鹽衊齋構繭壓蓋壓夢淵獵 (蓋構餘願壓積構膚齋鹽, 1.04) 更多
NCT06086444 (Pubmed \| J Plast Reconstr Aesthet Surg)	临床4期	-	60	Tranexamic acid (TXA) 10 mg/kg IV	鏇餘憲鑰選製夢糧夢積(醖製醖蓋積淵艱鏇積積) = remained below 400 mL in all cases, and no transfusions were required 獵構鹹壓網製夢鑰網鹹 (壓選餘廠鑰製鹽鑰齋鏇 ) 更多	不佳	2026-02-01
				Placebo
NCT05811676 (TRAPP-, Pubmed \| Matern Fetal Med)	临床3期	前置胎盘	1,680	Tranexamic acid 1 g	膚壓夢壓衊蓋鑰鹹糧範(淵繭獵製鹽顧艱選膚製) = 淵顧獵選膚壓糧遞鑰襯網構鏇齋淵鹽獵廠艱範 (淵製選糧艱獵築遞鑰選 ) 更多	积极	2026-01-01