KAT2B

NEWTON, Mass., April 28, 2025 (GLOBE NEWSWIRE) -- Auron Therapeutics, a clinical-stage biotechnology company targeting cell-state plasticity to improve patient outcomes in oncology and inflammatory disease, today announced preclinical data in prostate cancer at the American Association for Cancer Research (AACR) Annual Meeting in Chicago, IL. Using a series of experiments, Auron demonstrated activity with AUTX-703, its oral, potent and selective degrader targeting KAT2A/B in cell lines and patient derived organoid models (PDXO) of neuroendocrine prostate cancer (NEPC) and castrate resistant prostate cancer (CRPC). In NEPC cell lines and PDXO models treated for up to 21 days, AUTX-703 mediated potent KAT2A/KAT2B degradation, inhibited cell growth and induced cell state differentiation. AUTX-703 alone or in combination with enzalutamide was also found to induce cell differentiation in androgen receptor (AR) sensitive and AR resistant prostate cancer cell lines. These data support advancing AUTX-703 into clinical development for multiple sub-types of prostate cancer. “These preclinical data show that AUTX-703 can effectively inhibit growth in multiple prostate cancer models, offering a novel approach to tackling these challenging cancers by targeting cell-state plasticity through KAT2A/B degradation,” said Kate Yen, Ph.D., Founder and Chief Executive Officer of Auron. “As we advance our first Phase 1 clinical trial in hematologic malignancies, these findings reinforce our confidence in AUTX-703’s potential to offer meaningful benefits to patients with multiple tumor types facing limited options.” About Auron Therapeutics Auron Therapeutics is a platform-powered, product-driven company targeting cell-state plasticity to improve patient outcomes in oncology and inflammatory disease. Auron pioneered its AURIGIN™ platform, which uses AI and machine learning to compare cell states and identify novel drug targets, optimal development models, and biomarkers to facilitate proper patient selection, ultimately accelerating the development of effective and durable therapies. Using AURIGIN, the Company is building a pipeline of small molecule targeted therapies, led by a first-in-class, oral KAT2A/B degrader, AUTX-703, which is being developed for the treatment of both hematologic malignancies and solid tumors. For more information, please visit aurontx.com and follow us on LinkedIn. Investor Contact: Renee LeckTHRUST Strategic Communicationsrenee@thrustsc.com Media Contact: Carly ScadutoCarly Scaduto ConsultingCarly@carlyscadutoconsulting.com

AUTX-703, a novel and potent oral KAT2A and KAT2B protein degrader, inhibits growth and induces profound, persistent cell state differentiation in SCLC models NEWTON, MA, USA I April 03, 2025 I Auron Therapeutics ,  a clinical-stage biotechnology company targeting cell-state plasticity to improve patient outcomes in oncology and inflammatory disease, today announced data from a poster presentation at the 2025 Hot Topic in Basic and Translational Science: Small Cell Lung Cancer Meeting in New York, NY. The poster presented data from AUTX-703, a potent, selective and orally bioavailable heterobifunctional degrader of KAT2A/B, an AURIGIN-identified histone acetyltransferase driving small cell lung cancer (SCLC) and other tumor types. In a series of experiments, Auron showed that treatment with AUTX-703 potently degraded KAT2A/B, inhibited tumor growth, and induced durable cell state differentiation across models of SCLC. “We are excited to continue building on our findings highlighting AUTX-703’s potential as a novel, potent, small molecule degrader capable of inducing prolonged differentiation and inhibiting tumor growth in primary tumor models of SCLC ,” said Kate Yen, Ph.D., Founder and Chief Executive Officer of Auron. “Importantly, we have found that targeting the cell state driver, i.e. KAT2A, promotes differentiation and obstructs growth irrespective of the genomic mutation. With treatment extending out past 100 days we are pleased to see durable effects on cell state differentiation in solid tumors and look forward to advancing our Phase 1 trial in hematologic malignancies.” Specifically, the poster findings demonstrated: About Auron Therapeutics Auron Therapeutics is a platform-powered, product-driven company targeting cell-state plasticity to improve patient outcomes in oncology and inflammatory disease. Auron pioneered its AURIGIN™ platform, which uses AI and machine learning to compare cell states and identify novel drug targets, optimal development models, and biomarkers to facilitate proper patient selection, ultimately accelerating the development of effective and durable therapies. Using AURIGIN, the Company is building a pipeline of small molecule targeted therapies, led by a first-in-class, oral KAT2A/B degrader, AUTX-703, which is being developed for the treatment of both hematologic malignancies and solid tumors. For more information, please visit aurontx.com and follow us on LinkedIn . SOURCE: Auron Therapeutics

AUTX-703, a novel and potent oral KAT2A and KAT2B protein degrader, inhibits growth and induces profound, persistent cell state differentiation in SCLC modelsNEWTON, Mass., April 03, 2025 (GLOBE NEWSWIRE) -- Auron Therapeutics, a clinical-stage biotechnology company targeting cell-state plasticity to improve patient outcomes in oncology and inflammatory disease, today announced data from a poster presentation at the 2025 Hot Topic in Basic and Translational Science: Small Cell Lung Cancer Meeting in New York, NY. The poster presented data from AUTX-703, a potent, selective and orally bioavailable heterobifunctional degrader of KAT2A/B, an AURIGIN-identified histone acetyltransferase driving small cell lung cancer (SCLC) and other tumor types. In a series of experiments, Auron showed that treatment with AUTX-703 potently degraded KAT2A/B, inhibited tumor growth, and induced durable cell state differentiation across models of SCLC. “We are excited to continue building on our findings highlighting AUTX-703’s potential as a novel, potent, small molecule degrader capable of inducing prolonged differentiation and inhibiting tumor growth in primary tumor models of SCLC ,” said Kate Yen, Ph.D., Founder and Chief Executive Officer of Auron. “Importantly, we have found that targeting the cell state driver, i.e. KAT2A, promotes differentiation and obstructs growth irrespective of the genomic mutation. With treatment extending out past 100 days we are pleased to see durable effects on cell state differentiation in solid tumors and look forward to advancing our Phase 1 trial in hematologic malignancies.” Specifically, the poster findings demonstrated: In SCLC cell lines, AUTX-703 treatment induces lasting effects, with prolonged treatment (over 100 days) driving a persistent epithelial transition and reduction in ASCL1 and L-MYC neuroendocrine markers.In SCLC patient-derived xenograft organoid (PDXO) models, AUTX-703 potently inhibits in vitro organoid and in vivo tumor growth and is well tolerated with oral dosing.In responding models, AUTX-703 decreases expression of MYC target genes.In models that undergo epithelial differentiation, AUTX-703 enhanced expression of antigen presentation genes, suggesting the potential to combine AUTX-703 with immune checkpoint inhibitors.In models that undergo neural differentiation, AUTX-703 enhanced DLL3 expression, suggesting the potential to combine AUTX-703 with tarlatamab. About Auron Therapeutics Auron Therapeutics is a platform-powered, product-driven company targeting cell-state plasticity to improve patient outcomes in oncology and inflammatory disease. Auron pioneered its AURIGIN™ platform, which uses AI and machine learning to compare cell states and identify novel drug targets, optimal development models, and biomarkers to facilitate proper patient selection, ultimately accelerating the development of effective and durable therapies. Using AURIGIN, the Company is building a pipeline of small molecule targeted therapies, led by a first-in-class, oral KAT2A/B degrader, AUTX-703, which is being developed for the treatment of both hematologic malignancies and solid tumors. For more information, please visit aurontx.com and follow us on LinkedIn. Investor Contact: Renee LeckTHRUST Strategic Communicationsrenee@thrustsc.com Media Contact: Carly ScadutoCarly Scaduto ConsultingCarly@carlyscadutoconsulting.com