Consumers precluded from obtaining semaglutide or tirzepatide by clinicians or insurers are turning to natural “GLP-1” transdermal patches. The Dietary Supplement Health and Education Act specifies dietary supplement products must be swallowed, so all these products are illegal. We identified 24 transdermal patch dietary supplement products and 1 transdermal gel product with an average of 7 ± 4 natural ingredients (berberine, glutamine/glutamate, cinnamon, and pomegranate most listed). No certificates of analysis were posted, many products lacked the Food and Drug Administration disclaimer, and many products used deceptive advertising. Several products had 1- to 2-star reviews and consumer comments suggesting lack of efficacy or adverse events.

2026-08-01·BIOMEDICINE & PHARMACOTHERAPY

Protective effects of ACF210, a dual GLP-1/APJ receptor agonist, against cardiovascular-kidney-metabolic syndrome induced by T2D

Article

作者: Wu, Qingfeng ; Zhou, Huifen ; Zhao, Qingbin ; Wei, Huiyi ; Du, Yuanyuan

Current therapies cannot simultaneously address the interconnected metabolic, cardiac, and renal damage in Cardiovascular-Kidney-Metabolic (CKM) syndrome. This study investigated ACF210, a novel long-acting dual agonist targeting both GLP-1 and APJ receptors, as a potential treatment for type 2 diabetes (T2D)-induced CKM syndrome. ACF210 was synthesized by fusing the human IgG4 Fc fragment to the C-terminus of GLP-1 and the N-terminus of Elabela-21 (ELA). In vitro receptor activation assays confirmed that ACF210 effectively activated the GLP-1 and APJ receptor signaling simultaneously. db/db leptin receptor-deficient mice and high-fat diet/streptozotocin-induced T2D were treated with dulaglutide, Fc-ELA, or ACF210 for 12 weeks. We assessed tissue morphology, organ function, and serum biomarkers. Compared to the diabetic control mice, ACF210 significantly improved blood glucose control and pancreatic β-cell function. Crucially, ACF210 demonstrated superior multi-organ protective effects over other treatments. Specifically, ACF210 reduced hepatic steatosis and provided comprehensive cardiac protection by lessening mitochondrial damage and fibrosis, enhancing diastolic function, reducing heart failure biomarkers such as NT-proBNP, and promoting microangiogenesis. In the kidneys, ACF210 alleviated podocyte damage and thickening of the glomerular basement membrane, while improving renal function as indicated by reduced levels of urinary albumin-to-creatinine ratio (UACR) and serum cystatin C. In conclusion, ACF210 not only effectively alleviates dysglycemia by potentially enhancing β-cell function but also significantly protects against diabetes-associated hepatic, cardiac, and renal damage, supporting its further exploration for the clinical management of CKM syndrome.

2026-07-03·XENOBIOTICA

Steady-state pharmacokinetics of oral semaglutide using semi-mechanistic pharmacokinetic modelling and population simulations

Article

作者: Tiwari, Ayushi ; Natesan, Subramanian ; Akbar, Sideequl ; Joseph, Anumol ; Chilamakuri, Sudarshan Naidu ; Malayandi, Rajkumar

Semaglutide (SEM) is a GLP-1 analogue, administered subcutaneously or orally. Due to its large molecular structure, it has poor oral absorption and bioavailability. The reported oral bioavailability is 0.4% to 1% in the fasting state. Sodium N-[8-{2-hydroxybenzoyl} amino] caprylate (SNAC) is used as a permeation enhancer to improve gastric permeability and oral bioavailability.This study developed a semi-mechanistic pharmacokinetic (PK) model to predict the steady-state pharmacokinetics of oral SEM, primarily using published clinical data and literature-derived parameters. The present study investigated the impact of SNAC on the gastric absorption of SEM.The semi-mechanistic PK model was developed for the intravenous (IV) and oral formulations. The oral absorption model was developed for SEM at different single doses with varying amounts of SNAC. The dose, SNAC concentration, gastrointestinal permeability, and intestinal first-pass effect impact the PK of the oral SEM. Steady-state PK studies were used to validate the single-dose oral PK model. IV, single-dose, and multiple-dose oral PK models were developed and validated.The developed semi-mechanistic model could be useful for further development of mechanistic, physiologically based pharmacokinetic (PBPK) models for formulation development, drug interactions, and the influence of pharmacokinetics in special populations.

1,046

项与 Glucagon-Like-Peptide-1(Original Biomedicals) 相关的新闻（医药）

2026-07-31

·CVDAILY

全球糖尿病速递（第212期）｜T1DM胰岛素泵使用、口服GLP-1 RA用于肥胖/超重、GLP-1 RA用于T1DM

*本资料仅供医疗卫生专业人士参考，请勿向非医疗卫生专业人士发放截至07月31日15点59分，近期共有 487 本期刊发布了 863 篇文章，其中糖尿病相关的文章共 266 篇，覆盖 31 个领域的内容。中国专家参与发表的文章有 68 篇。今日，影响因子最高的文章刊登在 The Lancet (IF: 88.500) 期刊上。今日头条 Headlines 01 J Clin Endocrinol Metab IF: 05.100 成人1型糖尿病患者胰岛素泵使用与住院结局：2022年全国再入院数据库分析 Reshma Reguram, Rushi Shah, Tanisha Vora, Camelia Arsene, Geetha Krishnamoorthy, Sudhanva Neti, etc. 一项发表于The Journal of Clinical Endocrinology and Metabolism的研究，利用2022年全国再入院数据库（NRD），评估了胰岛素泵治疗与成人1型糖尿病（T1D）患者住院结局的关联。该回顾性队列研究纳入230,958例成人T1D指数入院患者，比较胰岛素泵治疗（联合或不联合注射胰岛素）与仅注射胰岛素对30天再入院和院内死亡率的影响。结果显示，胰岛素泵使用者的30天再入院率为14.64%，显著低于仅注射胰岛素使用者的20.63%。经多变量校正后，泵治疗与再入院风险降低23%相关（aHR 0.77, 95% CI 0.74-0.81, P<0.001）。在90天再入院分析中，这一关联仍然存在。院内死亡率方面，泵使用者的死亡率为0.90%（95% CI 0.78-1.05），低于注射使用者的1.31%（95% CI 1.21-1.42）。泵治疗与死亡率降低22%相关（aOR 0.78, 95% CI 0.66-0.93, P=0.006）。研究结论指出，在这一全国代表性队列中，胰岛素泵治疗与成人T1D患者较低的30天再入院和院内死亡率独立相关。本文由韩玉莲编辑扫描二维码查看源文 J Clin Endocrinol Metab | Ahead of Print. 10.1210/clinem/dgag307 02 Obesity IF: 04.700 口服GLP-1受体激动剂TERN-601用于成人肥胖/超重：安慰剂对照、多次递增剂量、1期和2期研究 W Timothy Garvey, Julio Rosenstock, Harold E Bays, Douglas Denham, Anita Kohli, Melanie Haines, etc. 一项发表于Obesity的研究评估了口服小分子GLP-1受体激动剂TERN-601在肥胖或超重成人中的安全性、耐受性、药代动力学和有效性。该研究包括1期（28天）和2期（12周）两个随机、双盲、安慰剂对照、多次递增剂量试验。在1期研究中，TERN-601在28天内产生剂量依赖性体重减轻，所有剂量组与安慰剂相比均具有统计学显著性。治疗还显示出与GLP-1一致的药效学效应，包括食欲减退和胃排空延迟。在2期研究中，TERN-601剂量≥500mg时，第12周的平均体重减轻百分比显著大于安慰剂。胃肠道治疗期间出现的不良事件与GLP-1受体激动剂类别一致，且呈剂量相关性。然而，2期研究中有3例受试者出现转氨酶升高，提示潜在药物性肝损伤。研究结论指出，TERN-601显示出温和的剂量依赖性体重减轻，胃肠道耐受性与GLP-1受体激动剂一致。但2期研究中观察到的肝脏安全性问题导致临床开发终止。这些数据有助于整体了解口服小分子GLP-1受体激动剂在肥胖治疗中的应用。本文由韩玉莲编辑扫描二维码查看源文 Obesity | Ahead of Print. 10.1002/oby.70271 03 Lancet Reg Health Eur IF: 13.000 GLP-1受体激动剂在1型糖尿病中的应用：拓展胰岛素以外的治疗领域 George D Dimitriadis, Vaia Lambadiari, etc. 1型糖尿病的代谢控制仍然面临挑战。尽管胰岛素治疗和技术不断进步，多数患者仍无法达到血糖目标，并存在低血糖、血糖波动、酮症酸中毒、体重增加、氧化应激及心血管/肾脏并发症的风险。胰岛内胰岛素对胰高血糖素分泌的调节受损导致高胰高血糖素血症。胰岛素抵抗在1型糖尿病早期即出现，与高血糖、高胰高血糖素血症和体重增加共同作用，形成恶性循环。因此，治疗需尽可能降低胰岛素剂量，这要求减少高胰高血糖素血症和预防体重增加以改善胰岛素敏感性。 GLP-1受体激动剂通过葡萄糖依赖性机制降低胰高血糖素、增强胰岛素分泌，延缓β细胞凋亡，促进体重减轻，延缓胃排空，改善胰岛素敏感性，并具有抗炎、抗氧化、血管舒张及心肾保护作用。因此，这类药物作为胰岛素的辅助治疗在1型糖尿病中具有潜力，临床上常超说明书使用。 Yazdanfard及其同事发表了首个为期两年的全国性真实世界研究，利用丹麦注册数据，评估了超说明书使用司美格鲁肽（从0.25 mg/周逐渐增至2.40 mg/周）联合胰岛素治疗879例1型糖尿病患者（基线糖化血红蛋白[HbA1c] 7.9%，体重指数[BMI] 31.9 kg/m²）的效果，并与3516例年龄/HbA1c/BMI匹配的非使用者对照。结果显示，使用司美格鲁肽的前6个月，HbA1c下降0.52%，两年后仅有小幅进一步降低，而对照组无变化。基线HbA1c较高的患者降幅更大，每日多次注射和胰岛素泵使用者效果相似。总胰岛素处方量减少8.2%，而对照组增加4.2%。由于59%的体重数据缺失，BMI变化未评估。但已知司美格鲁肽2.4 mg/周可使超重/肥胖者平均减重16%，部分超过25%。另一项26周研究显示，司美格鲁肽（从0.25 mg/周增至1 mg/周）使HbA1c降低0.3%，体重降低9.5%，葡萄糖在目标范围内时间[TIR]增加20%，基础及餐时胰岛素每日剂量均减少20%，餐时胰岛素减少更多。血糖改善在最初4周即出现，提示直接胰岛素节约效应。因此，开始司美格鲁肽后可能需要将胰岛素剂量减少20-30%以降低低血糖风险。该研究还显示，司美格鲁肽未增加低血糖或酮症酸中毒住院风险，支持其真实世界安全性。依从性从6个月的71%降至两年的25%，主要由于胃肠道副作用和缺乏报销。真实世界停药率高于临床试验。多项问题尚待解决：GLP-1RA对1型糖尿病心血管和肾脏并发症的影响需全面研究；停药后可能发生体重反弹（1-2年内恢复50-70%）；可能减少肌肉质量；口服司美格鲁肽、替尔泊肽、奥格列龙等新型药物需在1型糖尿病中评估安全性和有效性；GLP-1RA与快速血糖改善相关的视力并发症也需研究。本文由韩玉莲编辑扫描二维码查看源文 Lancet Reg Health Eur | Volume 67, Issue 10.1016/j.lanepe.2026.101782 中国发表（68） China Environmental research IF: 07.700Ahead of Print.No.01Residential greenness and incident type 2 diabetes: A large prospective cohort study in China integrating evidence from 17 global cohorts住宅绿化与2型糖尿病发病风险：中国大型前瞻性队列研究及17个全球队列的综合证据DOI: 10.1016/j.envres.2026.125363 Metabolism IF: 11.900Ahead of Print.No.02From metabolic subtypes to preventive decisions in high-risk type 2 diabetes从代谢亚型到高危2型糖尿病的预防决策DOI: 10.1016/j.metabol.2026.156718 Biomaterials IF: 12.900Ahead of Print.No.03Heat-treatment-programmed NiTi-5Cu (AH) bioactive orthodontic alloy enables Cu release for antibiofilm and periodontal protection in diabetic oral microenvironment热处理编程的NiTi-5Cu（AH）生物活性正畸合金在糖尿病口腔微环境中通过铜释放实现抗生物膜和牙周保护DOI: 10.1016/j.biomaterials.2026.124486 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.04Ubiquitin-specific protease 48: Molecular mechanisms, pathophysiological roles and therapeutic potential泛素特异性蛋白酶48：分子机制、病理生理作用及治疗潜力DOI: 10.1016/j.bbrc.2026.154362 Diabetes Res Clin Pract IF: 07.400Ahead of Print.No.05Cardiorenal-metabolic phenotypes and risks of mortality and cardiovascular outcomes in type 2 diabetes: a retrospective cohort study2型糖尿病心肾代谢表型与死亡及心血管结局风险：一项回顾性队列研究DOI: 10.1016/j.diabres.2026.113472 Food and chemical toxicology IF: 03.500Ahead of Print.No.06Chronic Toxic Effects of BDE-47 in C3H/He Mice Following Oral ExposureBDE-47经口暴露对C3H/He小鼠的慢性毒性效应DOI: 10.1016/j.fct.2026.116306 Oncogene IF: 07.300Ahead of Print.No.07LncRMRP drives bladder cancer invasion via a lactylation-driven positive feedback circuitLncRMRP通过乳酸化驱动的正反馈回路驱动膀胱癌侵袭DOI: 10.1038/s41388-026-03927-1 Hepatology international IF: 06.100Ahead of Print.No.08A global consensus on the critical care management of acute-on-chronic liver failure patients: the APASL ACLF Beijing Position Paper全球共识：慢加急性肝衰竭患者重症监护管理——APASL ACLF北京立场文件DOI: 10.1007/s12072-026-11116-1 Am J Prev Med IF: 04.500Ahead of Print.No.09Prediction models and nomograms for incident risk of chronic obstructive pulmonary disease in adults in Shanghai上海成年人慢性阻塞性肺疾病发病风险预测模型与列线图DOI: 10.1016/j.amepre.2026.108530 Photodiagnosis Photodyn Ther IF: 02.600Ahead of Print.No.10Light Exposure and Type 2 Diabetes Mellitus: A Bibliometric Analysis of Research Hotspots and Emerging Frontiers from 2001 to 2025光照暴露与2型糖尿病：2001至2025年研究热点与新兴前沿的文献计量学分析DOI: 10.1016/j.pdpdt.2026.105594 Arch Phys Med Rehabil IF: 03.700Ahead of Print.No.11Effects of Short-term High-intensity vs. Moderate-intensity Interval Training on Cardiopulmonary Fitness and Metabolic Health in Overweight or Obese Patients with Cardiovascular Disease: Evidence from China短期高强度间歇训练与中等强度间歇训练对超重或肥胖心血管疾病患者心肺适能与代谢健康的影响：来自中国的证据DOI: 10.1016/j.apmr.2026.07.020 Metabolism IF: 11.900Ahead of Print.No.12Complementary body weight and cardiometabolic benefits of higher GLP-1 and lower GIP: Genetic evidence from large-scale phenomic analyses较高GLP-1与较低GIP对体重和心血管代谢的互补益处：来自大规模表型组学分析的遗传证据DOI: 10.1016/j.metabol.2026.156711 The Lancet IF: 88.500Ahead of Print.No.13A novel unimolecular GLP1 and amylin receptor agonist for glucose and weight control一种新型单分子GLP1和胰淀素受体激动剂用于血糖和体重控制DOI: 10.1016/S0140-6736(26)01487-X Neuron IF: 15.000Ahead of Print.No.14A cortical-hypothalamic neural circuit for compulsive eating in mice小鼠强迫性进食的皮层-下丘脑神经环路DOI: 10.1016/j.neuron.2026.07.005 BMJ open IF: 02.300Volume 16, Issue 7No.15Latent profiles of self-management behaviours in patients with type 2 diabetes and their associations with metabolic outcomes in China: a multicentre cross-sectional study中国2型糖尿病患者自我管理行为的潜在剖面分析及其与代谢结局的关联：一项多中心横断面研究DOI: 10.1136/bmjopen-2026-116185 Regul Toxicol Pharmacol IF: 03.500Ahead of Print.No.1640-Week Repeat-Dose Toxicity, Toxicokinetics, and Immunogenicity of Efsubaglutide Alfa Following Subcutaneous Administration in Cynomolgus Monkeys依苏帕格鲁肽α在食蟹猴中皮下给药40周重复给药毒性、毒代动力学和免疫原性研究DOI: 10.1016/j.yrtph.2026.106192 Free radical biology & medicine IF: 08.200Ahead of Print.No.17Edaravone Attenuates Carbonyl-Stress-Driven ApoA-I Carboxymethylation and Macrophage Cholesterol-Handling Dysfunction in Diabetic Atherosclerosis依达拉奉减轻糖尿病动脉粥样硬化中羰基应激驱动的ApoA-I羧甲基化及巨噬细胞胆固醇处理功能障碍DOI: 10.1016/j.freeradbiomed.2026.07.044 Advanced science IF: 14.100Ahead of Print.No.18Soft Hypoxia-Adaptive Bioelectronics Integrating PEDOT:PSS/Polydopamine/Enzyme Biocomposites for Closed-Loop Therapeutics of Chronic Wounds整合PEDOT:PSS/聚多巴胺/酶生物复合物的软性低氧自适应生物电子学用于慢性伤口的闭环治疗DOI: 10.1002/advs.76904 Diab Vasc Dis Res IF: 03.000Volume 23, Issue 4No.19Association of domestic water hardness with incident diabetic retinopathy and the mediating role of GID8: A UK Biobank prospective cohort study家庭用水硬度与糖尿病视网膜病变发病风险的关联及GID8的中介作用：一项英国生物样本库前瞻性队列研究DOI: 10.1177/14791641261474108 PloS one IF: 02.600Volume 21, Issue 7No.20Leveraging expression quantitative trait loci information in single-cell resolution to identify cell-specific genes for gestational diabetes利用单细胞分辨率的表达数量性状位点信息识别妊娠期糖尿病的细胞特异性基因DOI: 10.1371/journal.pone.0355339 PloS one IF: 02.600Volume 21, Issue 7No.21Association of troponin-defined myocardial injury with adverse long-term survival among patients with chronic kidney disease肌钙蛋白定义的心肌损伤与慢性肾脏病患者不良长期生存的关联DOI: 10.1371/journal.pone.0354873 Human molecular genetics IF: 03.200Volume 35, Issue 16No.22Single-cell transcriptomic integrated with machine learning reveals human retinal cell-specific biomarkers in diabetic retinopathy单细胞转录组学结合机器学习揭示糖尿病视网膜病变中人类视网膜细胞特异性生物标志物DOI: 10.1093/hmg/ddag069 European journal of nutrition IF: 04.300Volume 65, Issue 5No.23Sex-specific associations of urinary zinc, iron, and zinc-to-iron ratio with obesity indicators and phenotypes尿锌、铁及锌铁比与肥胖指标和表型的性别特异性关联DOI: 10.1007/s00394-026-04067-8 Stem cell reviews and reports IF: 04.200Ahead of Print.No.24DMBT1 in Adipose-Derived Stem Cell-Derived Exosomes Participates in Alleviating Ferroptosis to Promote Diabetic Wound Healing脂肪干细胞来源外泌体中的DMBT1通过缓解铁死亡促进糖尿病伤口愈合DOI: 10.1007/s12015-026-11201-w J Intensive Care Med IF: 02.100Ahead of Print.No.25The Nonlinear Impact of Cumulative Fluid Balance on Severe Acute Kidney Injury During the First Three ICU Days in Sepsis脓毒症患者ICU前三天累积液体平衡对严重急性肾损伤的非线性影响DOI: 10.1177/08850666261446558 Frontiers in bioscience IF: 03.100Volume 31, Issue 7No.26The Role of Gut Microbiota in Osteoporosis Triggered by High-Fat Diets: Mechanisms and Targeted Therapeutic Strategies高脂饮食诱发骨质疏松中肠道菌群的作用：机制与靶向治疗策略DOI: 10.31083/FBL46209 J Int Med Res IF: 01.500Volume 54, Issue 7No.27Causal relationship between aging-related biomarkers and osteoporosis: A bidirectional two-sample Mendelian randomization study衰老相关生物标志物与骨质疏松症的因果关系：一项双向两样本孟德尔随机化研究DOI: 10.1177/03000605261469014 Acta diabetologica IF: 02.900Ahead of Print.No.28The dawn phenomenon in diabetes: pathophysiology from periphery to central nervous system and circadian rhythm-based therapeutic strategies糖尿病中的黎明现象：从外周到中枢神经系统的病理生理学及基于昼夜节律的治疗策略DOI: 10.1007/s00592-026-02763-9 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.29Islet-Resident Macrophages as Dynamic Immunometabolic Integrators of β-Cell Fate in Health and Diabetes胰岛驻留巨噬细胞作为健康和糖尿病中β细胞命运的动态免疫代谢整合者DOI: 10.1111/dom.71154 Frontiers in bioscience IF: 03.100Volume 31, Issue 7No.30Resveratrol-Mediated Regulation of Molecular and Cellular Signaling Networks in Polycystic Ovary Syndrome白藜芦醇介导的多囊卵巢综合征分子与细胞信号网络调控DOI: 10.31083/FBL50398 Int J Rheum Dis IF: 02.000Volume 29, Issue 8No.31Dual Roles of Free Fatty Acids in Gout Pathogenesis: Inflammatory Drivers and Metabolic Mediators游离脂肪酸在痛风发病机制中的双重作用：炎症驱动因子与代谢调节介质DOI: 10.1111/1756-185x.70799 J Integr Neurosci IF: 02.700Volume 25, Issue 7No.32Brain-Wide Connectivity of GLP1R Neurons in the Thalamic Reticular Nucleus丘脑网状核中GLP1R神经元全脑连接图谱DOI: 10.31083/JIN52117 Revista de neurología IF: 00.800Volume 81, Issue 7No.33Association and Risk-Stratification Value of the Positive Remodeling Index of Middle Cerebral Artery Atherosclerotic Plaques for Perforator-Territory Infarction Based on High-Resolution Magnetic Resonance Imaging基于高分辨率磁共振成像的大脑中动脉粥样硬化斑块正性重构指数与穿支动脉区梗死的关联及风险分层价值DOI: 10.31083/RN53244 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.34Efficacy and Safety of Bimagrumab in Adults With Obesity and Metabolic Dysfunction: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsBimagrumab在肥胖和代谢功能障碍成人中的有效性和安全性：随机对照试验的系统评价和荟萃分析DOI: 10.1111/dom.71156 Revista de neurología IF: 00.800Volume 81, Issue 7No.35AI-Enabled Modeling for Alzheimer's Disease Risk Prediction and Validation基于人工智能的阿尔茨海默病风险预测模型构建与验证DOI: 10.31083/RN49220 Frontiers in public health IF: 03.400Volume 14, Issue No.36Physical fitness components as mediators between physical activity and executive function in adolescents: a cross-sectional study体力活动与青少年执行功能关系中体能成分的中介作用：一项横断面研究DOI: 10.3389/fpubh.2026.1824502 Frontiers in medicine IF: 03.000Volume 13, Issue No.37Digital health technologies in obesity: trajectory, emerging hotspots, and future perspectives数字健康技术在肥胖领域的应用：发展轨迹、新兴热点与未来展望DOI: 10.3389/fmed.2026.1875769 FCVM IF: 02.900Volume 13, Issue No.38Association of plasma homocysteine with the atherogenic index of plasma and modification by body mass index: a cross-sectional study血浆同型半胱氨酸与血浆致动脉粥样硬化指数的关联及体重指数的修饰作用：一项横断面研究DOI: 10.3389/fcvm.2026.1806051 Food science & nutrition IF: 03.800Volume 14, Issue 8No.39Synergistic Anti-Obesity Effect of Akkermansia muciniphila AKM Lab-01 and Garcinia cambogia Extract via Gut Microbiota Remodeling in Diet-Induced Obese MiceAkkermansia muciniphila AKM Lab-01与藤黄果提取物通过肠道菌群重塑在饮食诱导肥胖小鼠中的协同抗肥胖作用DOI: 10.1002/fsn3.72140 Frontiers in public health IF: 03.400Volume 14, Issue No.40Effects of 75 min of weekly exercise snacks on body composition, cardiometabolic health, cardiorespiratory fitness, and lower-body explosive power in overweight and obese female university students每周75分钟碎片化运动对超重和肥胖女大学生身体成分、心血管代谢健康、心肺适能及下肢爆发力的影响DOI: 10.3389/fpubh.2026.1846870 Cytotechnology IF: 01.700Volume 78, Issue 5No.41MGRN1 alleviates the progression of obesity-related acute lung injury by protecting lung epithelial cells through restoring mitochondrial functionMGRN1通过恢复线粒体功能保护肺上皮细胞减轻肥胖相关急性肺损伤的进展DOI: 10.1007/s10616-026-01038-z Frontiers in physiology IF: 03.400Volume 17, Issue No.42Divergent responses of adiponectin and leptin to exercise in women with overweight or obesity: a systematic review and meta-regression超重或肥胖女性运动后脂联素和瘦素的不同反应：系统评价与Meta回归DOI: 10.3389/fphys.2026.1810408 Frontiers in surgery IF: 01.800Volume 13, Issue No.43Internal carotid artery fenestration with contralateral internal carotid artery dissection: a case report and literature review颈内动脉开窗伴对侧颈内动脉夹层：病例报告与文献综述DOI: 10.3389/fsurg.2026.1864348 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.44Prepregnancy body mass index and risk of macrosomia after fresh embryo transfer: a retrospective cohort study with exploratory threshold analysis孕前体重指数与新鲜胚胎移植后巨大儿风险：一项回顾性队列研究及探索性阈值分析DOI: 10.3389/fendo.2026.1884067 Frontiers in medicine IF: 03.000Volume 13, Issue No.45Development and validation of a deep neural network for predicting coronary heart disease in hypertensive patients using 24-hour ambulatory blood pressure monitoring: a retrospective study基于24小时动态血压监测的深度神经网络预测高血压患者冠心病风险：一项回顾性研究DOI: 10.3389/fmed.2026.1860785 Frontiers in medicine IF: 03.000Volume 13, Issue No.46Evaluating large language models for diabetic retinopathy multiple-choice question generation in clinical ophthalmic education评估大语言模型在临床眼科教育中生成糖尿病视网膜病变选择题的能力DOI: 10.3389/fmed.2026.1874243 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.47Diagnostic accuracy and clinical performance of deep learning models for grading diabetic retinopathy: a systematic review and meta-analysis深度学习模型在糖尿病视网膜病变分级中的诊断准确性和临床性能：系统评价与荟萃分析DOI: 10.3389/fendo.2026.1853785 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.48Association between albuminuria and prevalent diabetic retinopathy in type 2 diabetes: a cross-sectional study with exploratory analysis by carotid plaque status白蛋白尿与2型糖尿病中糖尿病视网膜病变患病率的关联：一项基于颈动脉斑块状态的探索性横断面研究DOI: 10.3389/fendo.2026.1866206 Frontiers in pharmacology IF: 04.800Volume 17, Issue No.49Druggable Mendelian randomization prioritizes CDH2 and supports finerenone as a candidate therapeutic strategy for diabetic retinopathy药物靶点孟德尔随机化研究优先考虑CDH2并支持非奈利酮作为糖尿病视网膜病变的候选治疗策略DOI: 10.3389/fphar.2026.1865172 Frontiers in public health IF: 03.400Volume 14, Issue No.50Hospital burden, amputation risk, and mortality trends in diabetic foot patients: a retrospective public health analysis糖尿病足患者的医院负担、截肢风险及死亡率趋势：一项回顾性公共卫生分析DOI: 10.3389/fpubh.2026.1753221 Front Cell Infect Microbiol IF: 04.800Volume 16, Issue No.51Microbial dysbiosis and wound healing in diabetic foot ulcers: a mini review with a note on the role of artificial intelligence糖尿病足溃疡中的微生物失调与伤口愈合：小型综述及人工智能作用的说明DOI: 10.3389/fcimb.2026.1891884 Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 7No.52Association of Pitavastatin Versus Atorvastatin Therapy With Glycaemic Control and New-Onset Diabetes in Older Adults With Atherosclerotic Cardiovascular Disease匹伐他汀对比阿托伐他汀治疗对老年动脉粥样硬化性心血管疾病患者血糖控制和新发糖尿病的影响DOI: 10.31083/BJHM56151 Journal of diabetes IF: 03.700Volume 18, Issue 8No.53Insulin Resistance Emerges Early After Glucocorticoid Treatment in Adult Patients With 21-Hydroxylase Deficiency21-羟化酶缺乏症成年患者糖皮质激素治疗后早期出现胰岛素抵抗DOI: 10.1111/1753-0407.70258 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.54Association of the C-reactive protein-triglyceride glucose index with microvascular obstruction and long-term prognosis in patients with acute myocardial infarction: a CMR-based studyC反应蛋白-甘油三酯葡萄糖指数与急性心肌梗死患者微血管阻塞及长期预后的关联：一项基于心脏磁共振的研究DOI: 10.3389/fendo.2026.1889147 Frontiers in microbiology IF: 04.500Volume 17, Issue No.55Decoding the gut-adipose-ovary axis in polycystic ovary syndrome: from metabolic dysregulation to oncological risk modulation解码多囊卵巢综合征中的肠-脂肪-卵巢轴：从代谢失调到肿瘤风险调控DOI: 10.3389/fmicb.2026.1882127 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.56Acute TRPTI™ (oleoylethanolamide) supplementation enhances incretin hormone responses: a fixed-sequence crossover study急性TRPTI™（油酰乙醇胺）补充增强肠促胰岛素激素反应：一项固定序列交叉研究DOI: 10.3389/fendo.2026.1879799 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.57Global research landscape and trends of metabolomics in diabetic kidney disease: focus on immunometabolic interactions糖尿病肾脏病代谢组学的全球研究格局与趋势：聚焦免疫代谢相互作用DOI: 10.3389/fcdhc.2026.1791774 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.58Marked and reversible circulating insulin-like growth factor-1 elevation during teprotumumab N01 treatment for thyroid eye disease with limited correspondence to glycemic changes替妥木单抗N01治疗甲状腺眼病期间循环胰岛素样生长因子-1显著且可逆性升高与血糖变化关联有限DOI: 10.3389/fendo.2026.1870933 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.59Case Report: Case analysis of a juvenile type 1 diabetes mellitus patient with Mauriac syndrome病例报告：一例青少年1型糖尿病合并Mauriac综合征患者的病例分析DOI: 10.3389/fendo.2026.1858339 Frontiers in oncology IF: 03.300Volume 16, Issue No.60Independent and sex-stratified association between microsatellite instability and peripheral hemoglobin in colorectal cancer结直肠癌中微卫星不稳定性与外周血红蛋白的独立及性别分层关联DOI: 10.3389/fonc.2026.1890542 Frontiers in public health IF: 03.400Volume 14, Issue No.61National divergence in cardio-kidney-metabolic syndrome burden and implications for health policy: a global burden of disease analysis with projections to 2050心肾代谢综合征负担的国家差异及其对卫生政策的影响：一项全球疾病负担分析及至2050年的预测DOI: 10.3389/fpubh.2026.1858041 Frontiers in nutrition IF: 05.100Volume 13, Issue No.62Nutrient metabolic heterogeneity across renal stages in patients with type 2 diabetes mellitus and diabetic kidney disease2型糖尿病合并糖尿病肾病患者不同肾功能分期的营养代谢异质性DOI: 10.3389/fnut.2026.1885766 Frontiers in aging neuroscience IF: 04.500Volume 18, Issue No.63Heterogeneous cognitive and neuroimaging profiles in older adults with type 2 diabetes: the modifying effect of coronary artery disease老年2型糖尿病患者认知与神经影像异质性：冠状动脉疾病的修饰效应DOI: 10.3389/fnagi.2026.1825819 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.64The optimal exercise modality and dose for glycemic control in older adults with type 2 diabetes mellitus: a systematic review and network meta-analysis老年2型糖尿病患者血糖控制的最佳运动方式和剂量：系统评价和网络荟萃分析DOI: 10.3389/fendo.2026.1832624 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.65A nomogram integrating machine learning with clinical predictors for osteosarcopenia risk prediction in type 2 diabetes mellitus整合机器学习与临床预测因素的列线图用于预测2型糖尿病患者骨肌减少症风险DOI: 10.3389/fendo.2026.1876521 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.66Periapical abscess precipitating diabetic ketoacidosis and reversible sepsis-induced cardiomyopathy: a case report根尖周脓肿诱发糖尿病酮症酸中毒和可逆性脓毒症心肌病：一例病例报告DOI: 10.3389/fendo.2026.1853265 Frontiers in medicine IF: 03.000Volume 13, Issue No.67Fetal growth in PCOS pregnancies: dynamic evidence of restriction and the modifying role of ART多囊卵巢综合征妊娠中的胎儿生长：受限的动态证据及辅助生殖技术的调节作用DOI: 10.3389/fmed.2026.1857905 Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 7No.68Impact of Labor Analgesia on Delivery Outcomes in Parturients With Gestational Diabetes Mellitus分娩镇痛对妊娠期糖尿病产妇分娩结局的影响DOI: 10.31083/BJHM56149 其他发布内容（195） More Published Articles Diabetic medicine IF: 03.400Ahead of Print.No.01Embedding psychological care in diabetes services: Why it's time to innovate and integrate将心理护理融入糖尿病服务：为何是时候创新与整合DOI: 10.1111/dme.70411 Hormones IF: 02.500Ahead of Print.No.02GnRH pulse frequency is decoded by distinct Gαs- and Gαq/11-mediated signaling pathways in gonadotropes in vitroGnRH脉冲频率通过促性腺激素细胞中不同的Gαs和Gαq/11介导的信号通路解码DOI: 10.1007/s42000-026-00815-x J Gen Intern Med IF: 04.200Ahead of Print.No.03Feasibility of a Church-Based, CHW-Delivered Diabetes and SDOH Intervention in a Hispanic Community: A Quasi-Experimental Study基于教堂的社区卫生工作者主导的糖尿病与社会健康决定因素干预在西班牙裔社区中的可行性：一项准实验研究DOI: 10.1007/s11606-026-10668-0 J Racial Ethn Health Disparities IF: 02.400Ahead of Print.No.04Colorectal Cancer Screening in Black and Latino Adults with Type 2 Diabetes: Associations with Modifiable Health Behaviors and Sociodemographic Factors黑人和拉丁裔2型糖尿病成人的结直肠癌筛查：与可改变的健康行为和社会人口学因素的关联DOI: 10.1007/s40615-026-03128-2 Infection IF: 03.600Ahead of Print.No.05Impact of SGLT2 inhibitors on asymptomatic bacteriuria in T2DM: prevalence, pathogens and risk factorsSGLT2抑制剂对2型糖尿病无症状菌尿的影响：患病率、病原体和危险因素DOI: 10.1007/s15010-026-02905-9 Lasers in medical science IF: 02.400Volume 41, Issue 1No.06Low-level laser therapy and conventional treatment for diabetic foot ulcers: a case series低水平激光治疗与常规治疗糖尿病足溃疡的病例系列研究DOI: 10.1007/s10103-026-04968-4 Bone Research IF: 15.000Volume 14, Issue 1No.07DMP1-Cre expressing cells mediate the gain in bone mass and strength, but not the increase in bone remodeling, induced by ligands of the parathyroid hormone receptorDMP1-Cre表达细胞介导甲状旁腺激素受体配体诱导的骨量和强度增加，但不介导骨重塑增加DOI: 10.1038/s41413-026-00555-z Journal of biophotonics IF: 02.300Volume 19, Issue 8No.08Hexagonal Hollow-Core Photonic Crystal Fiber for High-Sensitivity Terahertz Glucose Detection用于高灵敏度太赫兹葡萄糖检测的六边形空芯光子晶体光纤DOI: 10.1002/jbio.70332 Primary care diabetes IF: 02.300Ahead of Print.No.09New-onset diabetes mellitus after pancreatectomy: A scoping review胰切除术后新发糖尿病的范围综述DOI: 10.1016/j.pcd.2026.07.011 AJC IF: 02.100Ahead of Print.No.10Sex Differences in Clinical Outcomes after Bifurcation Percutaneous Coronary Intervention: Findings from the PROGRESS-BIFURCATION Registry分叉病变经皮冠状动脉介入治疗后临床结局的性别差异：PROGRESS-BIFURCATION注册研究结果DOI: 10.1016/j.amjcard.2026.07.028 AJOG IF: 08.400Ahead of Print.No.11Abnormal serum sFlt-1 and PlGF as markers of occult placental dysfunction and fetal risk in pregestational diabetes: A Prospective Masked Cohort Study孕前糖尿病中血清sFlt-1和PlGF异常作为隐匿性胎盘功能障碍和胎儿风险的标志物：一项前瞻性盲法队列研究DOI: 10.1016/j.ajog.2026.07.026 Int J Infect Dis IF: 04.300Ahead of Print.No.12Comparative characteristics and outcomes of bacterial and fungal skull base osteomyelitis: a retrospective analysis of 127 cases细菌性与真菌性颅底骨髓炎的特征与预后比较：127例回顾性分析DOI: 10.1016/j.ijid.2026.109017 Ophthalmology IF: 09.500Ahead of Print.No.13Factors Associated with Endothelial Cell Density at One Year in the Diabetes Endothelial Keratoplasty Study糖尿病角膜内皮移植术后一年内皮细胞密度的相关因素DOI: 10.1016/j.ophtha.2026.07.027 Indian Heart Journal IF: 01.800Ahead of Print.No.14Re: Cardiovascular Risk Profile among Industrial Workers in North India: A Cross-Sectional Study回复：北印度产业工人心血管风险概况：一项横断面研究DOI: 10.1016/j.ihj.2026.07.007 Experimental gerontology IF: 04.300Ahead of Print.No.15Prediction of end-stage renal disease progression and mortality of advanced chronic kidney disease based on one year of serum albumin changes: a retrospective cohort study基于一年血清白蛋白变化预测晚期慢性肾脏病进展至终末期肾病及死亡：一项回顾性队列研究DOI: 10.1016/j.exger.2026.113259 Forensic Sci Int Genet IF: 03.100Ahead of Print.No.16Species-origin identification of the deer in the Purtier Placenta Live Stem Cell Therapy by DNA typing通过DNA分型鉴定Purtier胎盘活干细胞疗法中鹿的种类来源DOI: 10.1016/j.fsigen.2026.103594 Biochem Biophys Res Commun IF: 02.200Ahead of Print.No.17Inhibition of mitochondrial complex I by rotenone reduces arterial calcification in vitro鱼藤酮抑制线粒体复合物I减少体外动脉钙化DOI: 10.1016/j.bbrc.2026.154344 J Stroke Cerebrovasc Dis IF: 01.800Ahead of Print.No.18Ischemic Stroke Following Transient Ischemic Attack: Sociodemographic and Clinical Risk Factors in a National Cohort短暂性脑缺血发作后缺血性卒中：全国队列中的社会人口学和临床危险因素DOI: 10.1016/j.jstrokecerebrovasdis.2026.108713 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.19Beyond Glycaemia: Fear of Hypoglycaemia, Cognition and Functional Mobility After Advanced Hybrid Closed-Loop Therapy in Older Adults With Type 1 Diabetes: A Prespecified Secondary Analysis of a Randomised, Single-Centre Study超越血糖：老年1型糖尿病患者接受先进混合闭环治疗后对低血糖的恐惧、认知和功能活动能力——一项随机单中心研究的预设次要分析DOI: 10.1111/dom.71170 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.20Real-World Effectiveness and Safety of Finerenone in People With Type 2 Diabetes and Chronic Kidney Disease: A Spanish Multicentre Retrospective Observational Study (MEDFINE-RWD)非奈利酮在2型糖尿病合并慢性肾脏病患者中的真实世界有效性与安全性：西班牙多中心回顾性观察研究（MEDFINE-RWD）DOI: 10.1111/dom.71160 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.21Economic Burden of Type 1 Diabetes in France法国1型糖尿病的经济负担DOI: 10.1111/dom.71103 Nature methods IF: 32.100Ahead of Print.No.22Light-activated tetanus neurotoxin for conditional proteolysis and inducible synaptic inhibition in vivo光激活破伤风神经毒素用于体内条件性蛋白水解和诱导性突触抑制DOI: 10.1038/s41592-026-03176-w Lancet Diabetes Endocrinol IF: 41.800Ahead of Print.No.23Type 1 diabetes in older populations老年人群中的1型糖尿病DOI: 10.1016/S2213-8587(26)00154-3 Redox biology IF: 11.900Ahead of Print.No.24Mitochondria-to-plasma-membrane H2O2 signaling induced by branched-chain keto acid oxidation essentially stimulates insulin secretion in pancreatic β-cells支链酮酸氧化诱导线粒体至质膜的H2O2信号传导对胰腺β细胞胰岛素分泌的必需刺激作用DOI: 10.1016/j.redox.2026.104309 J Reprod Immunol IF: 02.900Ahead of Print.No.25Polycystic ovary syndrome and insulin resistance: A focus on pathogenesis, risk factors, and therapeutic strategies多囊卵巢综合征与胰岛素抵抗：发病机制、危险因素及治疗策略的研究进展DOI: 10.1016/j.jri.2026.104943 The Lancet IF: 88.500Volume 408, Issue 10553No.26PUSH trial limits: why fluids still matter - Authors' replyPUSH试验的局限性：为何液体仍然重要——作者回复DOI: 10.1016/S0140-6736(26)01282-1 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.27Refining the Genetic Contribution to Type 2 Diabetes Subtypes细化2型糖尿病亚型的遗传贡献DOI: 10.1111/dom.71159 Surgical endoscopy IF: 02.700Ahead of Print.No.28Incisional hernia after laparoscopic and robotic donor nephrectomy: analysis of 325 consecutive donors腹腔镜与机器人辅助供肾切除术后切口疝：连续325例供者分析DOI: 10.1007/s00464-026-13207-4 Nature genetics IF: 29.000Ahead of Print.No.29Single-cell spatial mapping of human kidney development implicates the microenvironment in guiding cell fate decisions人类肾脏发育的单细胞空间图谱揭示微环境在指导细胞命运决定中的作用DOI: 10.1038/s41588-026-02665-0 Nature reviews. Disease primers IF: 60.600Volume 12, Issue 1No.30Bulimia nervosa神经性贪食症DOI: 10.1038/s41572-026-00726-6 Otolaryngol Clin North Am IF: 01.400Ahead of Print.No.31Effects of Body Weight on Middle Ear Disease体重对中耳疾病的影响DOI: 10.1016/j.otc.2026.05.004 Child health nursing researchVolume 32, Issue 3No.32Associations of asthma with obesity phenotypes and dyslipidemia among Korean adolescents: a secondary data analysis of the Eighth Korea National Health and Nutrition Examination Survey韩国青少年哮喘与肥胖表型及血脂异常的相关性：基于第八次韩国国民健康与营养调查的二次数据分析DOI: 10.4094/chnr.2025.040 Obesity IF: 04.700Ahead of Print.No.33Unanticipated Effects of GLP-1 Receptor Agonists: A Net PositiveGLP-1受体激动剂的意外效应：总体积极DOI: 10.1002/oby.70288 Obesity IF: 04.700Ahead of Print.No.34Epigenetic Signature of the Metastable Epiallele VTRNA2-1: Adipose Dysfunction and Suboptimal Bariatric Outcomes转移性表观等位基因VTRNA2-1的表观遗传特征：脂肪功能障碍与减重手术效果不佳DOI: 10.1002/oby.70268 Obesity IF: 04.700Ahead of Print.No.35Navigating the Numerous Frameworks for Obesity Care应对肥胖护理的众多框架DOI: 10.1002/oby.70273 Am J Prev Med IF: 04.500Ahead of Print.No.36Health Outcomes and Behavioral Risk Factors Among US Law Enforcement Officers美国执法人员的健康结局与行为风险因素DOI: 10.1016/j.amepre.2026.108529 Journal of nutrition IF: 03.800Ahead of Print.No.37Long-term supplementation with fruits and vegetables prevents cognitive impairment induced by a Western-style high-fat diet in male mice长期补充水果和蔬菜可预防西式高脂饮食诱导的雄性小鼠认知障碍DOI: 10.1016/j.tjnut.2026.101768 Cellular signalling IF: 03.700Ahead of Print.No.38A combined stimulus of acute fasting and exercise modulates hippocampal mitochondrial quality control in healthy mice急性禁食与运动联合刺激调节健康小鼠海马线粒体质量控制DOI: 10.1016/j.cellsig.2026.112774 J Thromb Haemost IF: 05.000Ahead of Print.No.39Plasma levels of adiponectin and risk of future incident venous thromboembolism血浆脂联素水平与未来静脉血栓栓塞风险DOI: 10.1016/j.jtha.2026.07.023 Neurobiology of disease IF: 05.600Ahead of Print.No.40The prolactin-releasing peptide system: Physiological functions and therapeutic potential in obesity催乳素释放肽系统：生理功能与肥胖治疗潜力DOI: 10.1016/j.nbd.2026.107554 Appetite IF: 03.800Ahead of Print.No.41Food reinforcement as a predictor of child dietary intake during a test meal食物强化作为儿童测试餐膳食摄入的预测因子DOI: 10.1016/j.appet.2026.108726 Journal of controlled release IF: 11.500Ahead of Print.No.42Bivalent gambogic acid-functionalized curcumin nanoparticles with insulin modulate the gut-liver-kidney network in type 2 diabetes双价藤黄酸功能化姜黄素纳米颗粒联合胰岛素调节2型糖尿病肠-肝-肾网络DOI: 10.1016/j.jconrel.2026.115224 The Lancet IF: 88.500Ahead of Print.No.43Efficacy and safety of once-weekly subcutaneous zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial每周一次皮下注射zenagamtide（一种新型单分子GLP-1和胰淀素受体激动剂）治疗2型糖尿病的有效性和安全性：一项多中心、随机、平行、双盲、安慰剂对照、剂量探索的2期试验DOI: 10.1016/S0140-6736(26)01248-1 The Lancet IF: 88.500Ahead of Print.No.44Efficacy and safety of once-daily oral zenagamtide, a novel unimolecular GLP-1 and amylin receptor agonist, in adults with type 2 diabetes: a multicentre, randomised, parallel, double-blind, placebo-controlled, dose-finding, phase 2 trial每日一次口服zenagamtide（一种新型单分子GLP-1和胰淀素受体激动剂）在成人2型糖尿病中的有效性和安全性：一项多中心、随机、平行、双盲、安慰剂对照、剂量探索的2期试验DOI: 10.1016/S0140-6736(26)01247-X The Lancet Healthy Longevity IF: 14.600Ahead of Print.No.45Adjunctive metformin for obesity and frailty in older people-puncturing inflated expectations?辅助二甲双胍治疗老年人肥胖与衰弱：戳破过高的期望？DOI: 10.1016/j.lanhl.2026.100890 The Lancet Healthy Longevity IF: 14.600Ahead of Print.No.46Metformin added to lifestyle intervention for physical function in older adults with obesity (DEMFOS trial): a randomised controlled trial二甲双胍联合生活方式干预对肥胖老年人身体机能的影响（DEMFOS试验）：一项随机对照试验DOI: 10.1016/j.lanhl.2026.100883 The Lancet IF: 88.500Volume 408, Issue 10553No.47How definitions shape obesity-attributable death estimates - Authors' reply定义如何影响肥胖归因死亡估计——作者回复DOI: 10.1016/S0140-6736(26)01133-5 The Lancet IF: 88.500Volume 408, Issue 10553No.48How definitions shape obesity-attributable death estimates定义如何影响肥胖归因死亡估计DOI: 10.1016/S0140-6736(26)01029-9 JMIR formative research IF: 02.100Ahead of Print.No.49Remote Glucose Monitoring Engagement and Glycemic Control in Type 2 Diabetes and Prediabetes: Retrospective Cohort Study远程血糖监测参与度与2型糖尿病及糖尿病前期血糖控制：回顾性队列研究DOI: 10.2196/95679 Tissue & cell IF: 02.500Ahead of Print.No.50Sesamol-loaded PLGA nanoparticles attenuate HFD-induced MASLD by modulating Nrf2/HO-1, mitochondria cascade, and TLR4/NF-κB signaling pathways in rats芝麻酚PLGA纳米颗粒通过调节Nrf2/HO-1、线粒体级联及TLR4/NF-κB信号通路减轻高脂饮食诱导的大鼠脂肪性肝病DOI: 10.1016/j.tice.2026.103812 J Microbiol Biotechnol IF: 03.100Volume 36, Issue No.51Protective Effects of Komagataeibacter rhaeticus SLAM-JS1B Derived Metabolites in High-Fat Diet-Induced ObesityKomagataeibacter rhaeticus SLAM-JS1B 来源代谢产物对高脂饮食诱导肥胖的保护作用DOI: 10.4014/jmb.2604.04041 J Gen Intern Med IF: 04.200Ahead of Print.No.52Spending and Affordability of Glucagon-Like Peptide-1 Receptor Agonists and Other Incretin Mimetics in the United States, 2013-20232013-2023年美国胰高血糖素样肽-1受体激动剂及其他肠促胰岛素类似物的支出与可负担性DOI: 10.1007/s11606-026-10658-2 Journal of chromatography IF: 04.000Ahead of Print.No.53Ion-exchange chromatography for impurity profiling of therapeutic peptides离子交换色谱用于治疗性肽的杂质谱分析DOI: 10.1016/j.chroma.2026.467292 Z Evid Fortbild Qual Gesundhwes IF: 01.700Ahead of Print.No.54Prevalence of thirst and xerostomia and their associated factors in patients with chronic heart failure in Germany: A multicenter cross-sectional study德国慢性心力衰竭患者口渴与口干的发生率及其相关因素：一项多中心横断面研究DOI: 10.1016/j.zefq.2026.06.006 Pharmaceutical research IF: 04.300Ahead of Print.No.55Impurities and Potential Immunogenicity Associated With Follow-on and Compounded Glucagon-like Peptide-1 Receptor Agonists仿制及复方胰高血糖素样肽-1受体激动剂中的杂质与潜在免疫原性DOI: 10.1007/s11095-026-04146-9 Transfus Apher Sci IF: 01.200Volume 65, Issue 4No.56Baseline-dependent immunometabolic effects of low-volume plasma exchange on inflammation and iron homeostasis in metabolic syndrome低容量血浆置换对代谢综合征炎症和铁稳态的基线依赖性免疫代谢效应DOI: 10.1016/j.transci.2026.104492 Journal of clinical apheresis IF: 02.700Volume 41, Issue 4No.57Plasmapheresis in Hypertriglyceridemia-Associated Acute Pancreatitis: Triglyceride Levels of 5000 mg/dL as a Proposed Threshold血浆置换在甘油三酯相关急性胰腺炎中的应用：提出5000 mg/dL作为阈值DOI: 10.1002/jca.70165 Bioorganic chemistry IF: 04.700Ahead of Print.No.58Dual-target inhibitors against α-amylase and α-glucosidase: novel anacardic acid depside derivatives靶向α-淀粉酶和α-葡萄糖苷酶的双靶点抑制剂：新型腰果酚酸缩酚酸衍生物DOI: 10.1016/j.bioorg.2026.110306 European journal of pediatrics IF: 02.600Volume 185, Issue 8No.59Screening of pre-type 1 diabetes in high-risk paediatric population: a pilot study in Latvia拉脱维亚高危儿科人群中前1型糖尿病的筛查：一项试点研究DOI: 10.1007/s00431-026-07278-7 BMJ open ophthalmology IF: 02.200Volume 11, Issue 3No.60Screening for diabetic retinopathy with artificial intelligence in a primary care setting: a comparative cost analysis基层医疗机构中人工智能筛查糖尿病视网膜病变的成本比较分析DOI: 10.1136/bmjophth-2026-002904 RMD open IF: 04.700Volume 12, Issue 3No.61Maternal weight and hypertension as risk factors for juvenile idiopathic arthritis: a prospective population-based pregnancy cohort study母体体重与高血压作为幼年特发性关节炎的危险因素：一项基于人群的前瞻性妊娠队列研究DOI: 10.1136/rmdopen-2026-006940 Eur J Intern Med IF: 06.100Ahead of Print.No.62Sugar and artificial sweeteners and risk of cardiovascular disease糖与人造甜味剂及心血管疾病风险DOI: 10.1016/j.ejim.2026.107090 Environment international IF: 09.700Ahead of Print.No.63Long-term exposure to outdoor artificial light-at-night and its associations with natural-cause and cause-specific mortality: a register-based cohort study in the Netherlands长期暴露于室外夜间人造光与自然原因及特定原因死亡率的关联：荷兰一项基于登记处的队列研究DOI: 10.1016/j.envint.2026.110437 RMD open IF: 04.700Volume 12, Issue 3No.64Concurrent initiation of tirzepatide and biologics improves patient-reported outcomes in obese psoriatic arthritis: a propensity score-matched study替尔泊肽与生物制剂同时启动改善肥胖银屑病关节炎患者报告结局：倾向评分匹配研究DOI: 10.1136/rmdopen-2026-006830 Transplantation reviews IF: 02.500Ahead of Print.No.65Preventing delayed graft function after kidney transplantation: The emerging role of the perioperative period预防肾移植术后移植物功能延迟恢复：围手术期的新兴作用DOI: 10.1016/j.trre.2026.101043 Neuroscience IF: 02.800Volume 611, Issue No.66Developmental switch of GABAergic signaling in starburst amacrine cells driven by chloride transporter dynamics氯离子转运体动力学驱动的星爆无长突细胞GABA能信号发育性转换DOI: 10.1016/j.neuroscience.2026.07.007 Spine IF: 03.500Ahead of Print.No.67Letter to the Editor Regarding "Long-Term Mechanical Complications After Lumbar Fusion in Patients Receiving Tirzepatide vs Other GLP-1 Receptor Agonists"致编辑的信：关于“接受替尔泊肽与其他GLP-1受体激动剂的患者腰椎融合术后长期机械并发症”DOI: 10.1097/BRS.0000000000005792 PloS one IF: 02.600Volume 21, Issue 7No.68Bioassay-guided isolation of antioxidant, antibacterial, and antidiabetic compounds from Aleuritopteris bicolor of Nepal: In vitro/in silico study尼泊尔双色粉背蕨中抗氧化、抗菌和抗糖尿病化合物的生物活性导向分离：体外/计算机模拟研究DOI: 10.1371/journal.pone.0354665 Patient education and counseling IF: 03.100Ahead of Print.No.69Promoting patient empowerment in chronic care: A scoping review of key facilitating factors促进慢性病护理中的患者赋权：关键促进因素的范围综述DOI: 10.1016/j.pec.2026.109802 Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.70Pulse waveform characteristics for diagnosis and longitudinal monitoring in heart failure with reduced ejection fraction脉搏波形特征在射血分数降低的心力衰竭诊断和纵向监测中的应用DOI: 10.1152/ajpheart.00036.2026 JMIR AI IF: 02.000Volume 5, Issue No.71Improving Clinical Validity in Synthetic Electronic Health Record Generation Using Best-of-N Sampling: Comparative Evaluation Study使用最佳N采样改进合成电子健康记录生成的临床有效性：比较评估研究DOI: 10.2196/90590 JCN IF: 02.600Ahead of Print.No.72Health Literacy and Blood Pressure Control: The Mediating Role of Self-Management Behaviors in Hypertensive Adults健康素养与血压控制：高血压成人自我管理行为的中介作用DOI: 10.1097/JCN.0000000000001376 Circulation Research IF: 16.200Volume 139, Issue 4No.73STING Goes Mitochondrial: A Metabolic Regulator in Diabetic CardiomyopathySTING进入线粒体：糖尿病心肌病中的代谢调节因子DOI: 10.1161/CIRCRESAHA.126.329116 PloS one IF: 02.600Volume 21, Issue 7No.74Predicting medication non-adherence using machine learning: Incorporating Complementary and Alternative Medicine (CAM) beliefs in Malaysian chronic disease patients利用机器学习预测药物不依从性：纳入马来西亚慢性病患者的补充与替代医学信念DOI: 10.1371/journal.pone.0354682 PLOS global public health IF: 02.500Volume 6, Issue 7No.75Disease control and its correlates among hypertensive, diabetic, and asthmatic patients enrolled in secondary-level Integrated Chronic Care Clinics in Neno District, rural Malawi马拉维农村地区Neno区二级综合慢性病诊所中高血压、糖尿病和哮喘患者的疾病控制及其相关因素DOI: 10.1371/journal.pgph.0006629 PloS one IF: 02.600Volume 21, Issue 7No.76Current immunosuppressive treatment and self-reported lifetime stroke history among United States adults: A cross-sectional study美国成年人当前免疫抑制治疗与自我报告终生卒中病史的横断面研究DOI: 10.1371/journal.pone.0355164 PloS one IF: 02.600Volume 21, Issue 7No.77Educational strategies to improve health literacy for people with type 2 diabetes in low socio-economic communities: A realist review protocol低社会经济社区2型糖尿病患者健康素养教育策略：一项现实主义综述方案DOI: 10.1371/journal.pone.0352599 Physiother Res Int IF: 01.800Volume 31, Issue 4No.78Effect of Buerger-Allen Exercises on Lower Extremity Perfusion in Diabetes Mellitus Patients Undergoing Coronary Artery Bypass Grafting With Saphenous Vein Harvesting: A Randomized Controlled TrialBuerger-Allen运动对接受大隐静脉采集的冠状动脉旁路移植术糖尿病患者下肢灌注的影响：一项随机对照试验DOI: 10.1002/pri.70308 Kidney360 IF: 03.000Volume 7, Issue 7No.79The Missing Axis: Cardiovascular-Kidney-Metabolic Risk After Gestational Diabetes缺失的轴线：妊娠期糖尿病后的心血管-肾脏-代谢风险DOI: 10.34067/KID.0000001297 Clinical cancer research IF: 10.200Ahead of Print.No.80Transcriptional signatures indicating RB function correlate with response to CDK4/6 inhibition in endometrial cancer指示RB功能的转录特征与子宫内膜癌CDK4/6抑制剂的客观缓解相关DOI: 10.1158/1078-0432.CCR-26-0071 PLOS pathogens IF: 04.900Ahead of Print.No.81Post-COVID impairment of T cell responses to community-acquired pathogens can be modified by activating cellular metabolism激活细胞代谢可改善COVID-19后T细胞对社区获得性病原体的应答受损DOI: 10.1371/journal.ppat.1013860 Rev Peru Med Exp Salud Publica IF: 01.000Volume 43, Issue 2No.82Feasibility and preliminary biomarker responses to capsules containing green coffee extract enriched with magnesium di-malate in women with type 2 diabetes mellitus: a randomized, placebo-controlled pilot trial含镁二苹果酸盐的绿咖啡提取物胶囊在2型糖尿病女性中的可行性和初步生物标志物反应：一项随机、安慰剂对照的初步试验DOI: 10.17843/rpmesp.2026.432.15505 Diab Vasc Dis Res IF: 03.000Volume 23, Issue 4No.83Relationship between non-O blood groups and microvascular risk in type 2 diabetes非O血型与2型糖尿病微血管风险的关系DOI: 10.1177/14791641261474101 Diabetes Metab Res Rev IF: 06.000Volume 42, Issue 6No.84Type 5 Diabetes Mellitus: Pathophysiology, Clinical Phenotype, and Nutritional Management5型糖尿病：病理生理学、临床表型与营养管理DOI: 10.1002/dmrr.70212 Epigenetics IF: 03.200Volume 21, Issue 1No.85Culture-dependent decoupling of H19 allele-specific expression from H19/IGF2:IG-DMR methylation in experimental models实验模型中H19等位基因特异性表达与H19/IGF2:IG-DMR甲基化的培养依赖性解偶联DOI: 10.1080/15592294.2026.2690360 STAR protocols IF: 01.300Ahead of Print.No.86Protocol to stress human primary pancreatic islets with diabetogenic factors for subsequent single-cell RNA sequencing用致糖尿病因子处理人原代胰岛以进行后续单细胞RNA测序的方案DOI: 10.1016/j.xpro.2026.104752 Am J Physiol Heart Circ Physiol IF: 04.100Ahead of Print.No.87Sex-specific association between obesity and sympathetic nerve activity in HFpEF射血分数保留的心力衰竭中肥胖与交感神经活动的性别特异性关联DOI: 10.1152/ajpheart.00214.2026 J Am Coll Health IF: 01.500Ahead of Print.No.88Current e-cigarette use among US college students: Intersectional examination of sexual and gender minority status and race/ethnicity美国大学生当前电子烟使用：性少数与性别少数身份及种族/族裔的交叉分析DOI: 10.1080/07448481.2026.2700374 JBJS case connectorVolume 16, Issue 3No.89Novel Use of Axial Cage With Nonvascularized Fibula Autograft for Ankle Arthrodesis After Bone Loss: A Case Report轴向融合器联合非血管化腓骨自体移植用于骨缺损后踝关节融合术的新应用：一例报告DOI: 10.2106/JBJS.CC.25.00696 PloS one IF: 02.600Volume 21, Issue 7No.90Association between anthropometric measures and abdominal wall thickness in patients with obesity: A cross-sectional CT study肥胖患者人体测量指标与腹壁厚度的关联：一项横断面CT研究DOI: 10.1371/journal.pone.0354274 Indian Journal of Ophthalmology IF: 01.800Volume 74, Issue 8No.91Comparison of clinical profiles of idiopathic intracranial hypertension in patients with and without anemia贫血与非贫血特发性颅内高压患者临床特征的比较DOI: 10.4103/IJO.IJO_2643_25 Dermatology IF: 02.700Ahead of Print.No.92Atopic disease prevalence by nativity, citizenship, and years of residence in the United States美国出生地、公民身份和居住年限与特应性疾病患病率的关系DOI: 10.1159/drm/ackag003 The journal of physiology IF: 04.400Volume 604, Issue 15No.93Improved subjective sleep quality in older adults by enhancing the GABAergic system in the sensorimotor cortex通过增强感觉运动皮层GABA能系统改善老年人主观睡眠质量DOI: 10.1113/JP290164 Experimental physiology IF: 02.800Volume 111, Issue 8No.94Effects of baclofen and lorazepam on interhemispheric inhibition in humans巴氯芬和劳拉西泮对人类半球间抑制的影响DOI: 10.1113/EP093963 Bull Exp Biol Med IF: 00.600Ahead of Print.No.95Protein Kinase C Blockers Do Not Reverse the Cardioprotective Effect of Probiotic Strains in Rats with a Systemic Inflammatory Response蛋白激酶C阻断剂不能逆转益生菌株在全身炎症反应大鼠中的心脏保护作用DOI: 10.1007/s10517-026-06696-9 Journal of robotic surgery IF: 03.000Volume 20, Issue 1No.96Comparative analysis of robotic assisted versus laparoscopic Roux-en-Y gastric bypass: a retrospective cohort study机器人辅助与腹腔镜Roux-en-Y胃旁路术的比较分析：一项回顾性队列研究DOI: 10.1007/s11701-026-03734-6 Clinical endocrinology IF: 02.400Ahead of Print.No.97Long-Term Outcomes of Gonadotropin-Releasing Hormone Analogue Therapy in Central Precocious Puberty: A Comparative Analysis of Obese and Normal-Weight Girls促性腺激素释放激素类似物治疗中枢性性早熟的长期结局：肥胖与正常体重女孩的比较分析DOI: 10.1111/cen.70195 Am J Physiol Endocrinol Metab IF: 03.100Ahead of Print.No.98GDF15 modulates mitochondrial content and differentiation-associated metabolic remodeling in skeletal muscle cellsGDF15调节骨骼肌细胞线粒体含量及分化相关的代谢重塑DOI: 10.1152/ajpendo.00438.2025 JAMA Network Open IF: 09.700Volume 9, Issue 7No.99Adiposity Excess and Vertebral Fractures in Patients With Breast Cancer Taking Aromatase Inhibitors接受芳香化酶抑制剂治疗的乳腺癌患者中脂肪过多与椎体骨折的关系DOI: 10.1001/jamanetworkopen.2026.26450 Endocrine IF: 02.900Volume 91, Issue 1No.100Correction: Endothelial function and peak heart rate in normal-weight women with polycystic ovary syndrome and normal-weight controls更正：正常体重多囊卵巢综合征女性与正常体重对照组的内皮功能和峰值心率DOI: 10.1007/s12020-026-04704-6 Graefes Arch Clin Exp Ophthalmol IF: 02.300Ahead of Print.No.101Choroidal vascularity and thickness modulation with topical nepafenac after phacoemulsification: a comparative study in diabetic and non-diabetic eyes局部使用奈帕芬酸对超声乳化术后脉络膜血管性和厚度的调节：糖尿病与非糖尿病眼的比较研究DOI: 10.1007/s00417-026-07432-9 Am J Physiol Gastrointest Liver Physiol IF: 03.300Ahead of Print.No.102Genetic and pharmacologic modulations elucidate NRF2 protective role in acute pancreatitis遗传和药理学调控阐明NRF2在急性胰腺炎中的保护作用DOI: 10.1152/ajpgi.00032.2026 Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.103Sex Differences in Urinary Extracellular Vesicles Originating from the Genitourinary System in Health and Disease健康和疾病状态下泌尿生殖系统来源的尿液细胞外囊泡的性别差异DOI: 10.1152/ajprenal.00402.2025 Radiol Cardiothorac Imaging IF: 04.200Volume 8, Issue 4No.104Effects of a Fasting-mimicking Diet on MRI-assessed Cardiac Structure and Function in Participants with Type 2 Diabetes模拟禁食饮食对2型糖尿病患者心脏结构和功能的MRI评估影响DOI: 10.1148/ryct.250547 Am J Physiol Renal Physiol IF: 03.400Ahead of Print.No.105Delayed conception or sildenafil prevents endothelial dysfunction in pregnant rats after renal ischemia-reperfusion延迟受孕或西地那非预防肾缺血再灌注后孕鼠的内皮功能障碍DOI: 10.1152/ajprenal.00181.2026 Eur J Endocrinol IF: 05.200Ahead of Print.No.106Low measured free testosterone is associated with worse sexual function in community-dwelling men低测量游离睾酮与社区男性性功能较差相关DOI: 10.1093/ejendo/lvag139 JACC: Case reportsVolume 31, Issue 29No.107From High-Risk to High-Reward: Surgical Rescue After TAVR: Prosthetic Valve Endocarditis从高风险到高回报：TAVR术后外科挽救——人工瓣膜心内膜炎DOI: 10.1016/j.jaccas.2026.108071 Urologia IF: 00.800Ahead of Print.No.108Risk factors and treatment of pyelonephritis requiring hemodialysis: A PRISMA-guided systematic review需要血液透析的肾盂肾炎的危险因素和治疗：一项PRISMA指导的系统评价DOI: 10.1177/03915603261468833 Drug development research IF: 04.200Volume 87, Issue 5No.109TrxR Inhibition and Nrf2-FOXO3 Modulation by Repurposed Drugs: A Redox Strategy to Reverse Cancer Multidrug Resistance老药新用通过抑制TrxR和调节Nrf2-FOXO3逆转肿瘤多重耐药的氧化还原策略DOI: 10.1002/ddr.70358 Andrology IF: 03.400Ahead of Print.No.110Prospective Short- and Long-Term Changes in Cardiometabolic Risk Markers Following Gender-Affirming Hormone Therapy性别确认激素治疗后心脏代谢风险标志物的前瞻性短期和长期变化DOI: 10.1111/andr.70335 Indian Pediatrics IF: 01.500Ahead of Print.No.111Cardiac Autonomic Neuropathy in Children and Youth with Type 1 Diabetes: A Pilot Study1型糖尿病儿童和青少年心脏自主神经病变：一项初步研究DOI: 10.1007/s13312-026-00418-0 Journal of molecular histology IF: 02.200Volume 57, Issue 4No.112Syntaxin-4, a key exocytosis mediating protein, shows heterogeneous expression in insulin-positive cells of human donors with new-onset and longer duration of type 1 diabetes: comparison with non-diabetic autoantibody-positive and -negative donorsSyntaxin-4，一种关键的胞吐介导蛋白，在新发和长病程1型糖尿病供体胰岛素阳性细胞中呈现异质性表达：与非糖尿病自身抗体阳性和阴性供体的比较DOI: 10.1007/s10735-026-10901-4 J Diabetes Sci Technol IF: 03.700Ahead of Print.No.113Distribution of Hypo- and Hyperglycemic Event Duration in Type 1 Diabetes Using Automated Insulin Delivery使用自动胰岛素输送的1型糖尿病低血糖和高血糖事件持续时间分布DOI: 10.1177/19322968261471164 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.114A New Highly Concentrated Insulin Aspart AT278 (500 U/mL) Demonstrates Ultra-Rapid Pharmacokinetic and Pharmacodynamic Properties in Type 2 Diabetes Regardless of BMI新型高浓度门冬胰岛素AT278（500 U/mL）在2型糖尿病中展示超快速药代动力学和药效学特性，且不受BMI影响DOI: 10.1111/dom.71150 Endocrinol Diabetes Metab IF: 02.600Volume 9, Issue 5No.115A Clinically Aligned Two-Stage Machine Learning Framework for Predicting Hungry Bone Syndrome After Parathyroidectomy临床对齐的两阶段机器学习框架预测甲状旁腺切除术后饥饿骨综合征DOI: 10.1002/edm2.70297 European journal of nutrition IF: 04.300Volume 65, Issue 5No.116Association between fish-related metabolites and metabolic syndrome risk factors in Japan: INTERLIPID metabolome -wide association study日本鱼类相关代谢物与代谢综合征危险因素的关联：INTERLIPID代谢组全关联研究DOI: 10.1007/s00394-026-04068-7 Stat Methods Med Res IF: 01.900Ahead of Print.No.117A flexible bivariate cure model with shared random effect and associated inference and application to diabetic retinopathy data具有共享随机效应的灵活双变量治愈模型及其推断和在糖尿病视网膜病变数据中的应用DOI: 10.1177/09622802261468019 Retina IF: 02.100Ahead of Print.No.118Type 4 macular neovascularization in eyes with diabetic retinopathy糖尿病视网膜病变眼中的4型黄斑新生血管DOI: 10.1097/IAE.0000000000004948 Acta ophthalmologica IF: 02.800Ahead of Print.No.119Inter-eye microvascular asymmetry across stages of diabetic retinopathy: An OCT angiography study糖尿病视网膜病变各阶段眼间微血管不对称性：一项OCT血管成像研究DOI: 10.1111/aos.70202 Current eye research IF: 02.000Ahead of Print.No.120Cross-Compartment Proteomic Signatures in Human Diabetic Retinopathy: A Systematic Review and Meta-Analysis人类糖尿病视网膜病变跨区室蛋白质组学特征的系统评价与荟萃分析DOI: 10.1080/02713683.2026.2704368 JAMA ophthalmology IF: 09.200Ahead of Print.No.121Risk of Pseudophakic Cystoid Macular Edema in Eyes With Previous Pars Plana Vitrectomy既往玻璃体切除术后眼发生人工晶体眼囊样黄斑水肿的风险DOI: 10.1001/jamaophthalmol.2026.2767 JAMA IF: 55.000Ahead of Print.No.122Dapagliflozin to Reduce the Risk of Perioperative Acute Kidney Injury in Elective Cardiac Surgery达格列净降低择期心脏手术围手术期急性肾损伤风险DOI: 10.1001/jama.2026.7477 JAMA IF: 55.000Ahead of Print.No.123Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: Research Summary达格列净与心脏手术后急性肾损伤：研究总结DOI: 10.1001/jama.2026.9483 JAMA IF: 55.000Ahead of Print.No.124Dapagliflozin and Acute Kidney Injury Following Cardiac Surgery: A Randomized Clinical Trial达格列净与心脏手术后急性肾损伤：一项随机临床试验DOI: 10.1001/jama.2026.9268 Prim Care Companion CNS DisordVolume 28, Issue 4No.125Abrupt Smoking Cessation Due to Sensory Aversion Following Tirzepatide Initiation使用替尔泊肽后因感官厌恶导致突然戒烟DOI: 10.4088/PCC.25cr04174 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.126SURPASS-CVOT and the Emerging Biology of Cardiometabolic BenefitSURPASS-CVOT研究与心脏代谢获益的新兴生物学机制DOI: 10.1111/dom.71175 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.127Effect of Medications for Type 2 Diabetes on Cardiovascular Events and Mortality: A Comprehensive Pairwise and Network Meta-Analysis2型糖尿病药物对心血管事件和死亡率的影响：一项全面的成对和网络荟萃分析DOI: 10.1111/dom.71128 Hepatology communications IF: 04.600Volume 10, Issue 8No.128High incidence of advanced liver disease and mortality in patients presenting with alcohol use disorder酒精使用障碍患者晚期肝病和死亡率高发DOI: 10.1097/HC9.0000000000000979 Acta diabetologica IF: 02.900Ahead of Print.No.129The gut-brain-mitochondria axis in type 2 diabetes-associated cognitive decline: mechanistic convergence, biomarkers, and therapeutic opportunities2型糖尿病相关认知衰退中的肠-脑-线粒体轴：机制汇聚、生物标志物与治疗机遇DOI: 10.1007/s00592-026-02749-7 EJPC IF: 07.500Ahead of Print.No.130"Pharmacological risk stratification of Lp(a): diabetes status may refine residual cardiovascular risk beyond ASCVD history" - authors' replyLp(a)的药理学风险分层：糖尿病状态可细化ASCVD病史之外的残余心血管风险——作者回复DOI: 10.1093/eurjpc/zwag403 J Clin Pharmacol IF: 02.300Volume 66, Issue 8No.131First-in-Human Study of a Long-Acting GLP-1 Receptor Agonist (TE-8105) in Overweight or Obese Adults Without Type 2 Diabetes Mellitus长效GLP-1受体激动剂（TE-8105）在超重或肥胖非2型糖尿病成人中的首次人体研究DOI: 10.1002/jcph.70224 Acta diabetologica IF: 02.900Ahead of Print.No.132Long-term effectiveness of a reminder system for postpartum glucose intolerance screening in gestational diabetes妊娠期糖尿病产后糖耐量筛查提醒系统的长期有效性DOI: 10.1007/s00592-026-02756-8 Diabetes, obesity & metabolism IF: 05.700Ahead of Print.No.133Feasibility of Decentralised Response-Guided Albuminuria Monitoring to Optimise Empagliflozin and Finerenone Therapy in Type 2 Diabetes and Chronic Kidney Disease分散式反应指导的白蛋白尿监测优化恩格列净和非奈利酮治疗2型糖尿病和慢性肾脏病的可行性DOI: 10.1111/dom.71147 Histochemistry and cell biology IF: 02.100Volume 164, Issue 1No.134Development of a 3D collagen type I hydrogel scaffold for modeling hyperglycemia-induced spinal neuronal damage and therapeutic evaluation开发用于模拟高血糖诱导的脊髓神经元损伤及治疗评估的3D I型胶原水凝胶支架DOI: 10.1007/s00418-026-02515-4 British journal of nutrition IF: 03.000Ahead of Print.No.135Cetoleic acid rich fish oil increases plasma levels of eicosapentaenoic and docosapentaenoic acids in healthy volunteers: a double-blinded, randomised, controlled trial富含鲸蜡烯酸的鱼油可增加健康志愿者血浆中二十碳五烯酸和二十二碳五烯酸水平：一项双盲随机对照试验DOI: 10.1017/S0007114526107958 Transl Vis Sci Technol IF: 02.600Volume 15, Issue 7No.136The Impact of Inflammatory Hyperreflective Spots and Hard Exudates on Retinal Function in Diabetic Retinal Disease炎症性高反射点和硬性渗出对糖尿病视网膜病变视网膜功能的影响DOI: 10.1167/tvst.15.7.34 Internal medicine journal IF: 01.500Ahead of Print.No.137Hypophosphataemia following iron infusion: a narrative review of an increasingly recognised complication铁剂输注后低磷血症：一种日益被认识的并发症的叙述性综述DOI: 10.1111/imj.70576 JACC: Case reportsVolume 31, Issue 30No.138This ECG Does Not Fit: Rethinking Left Ventricular Hypertrophy这份心电图不匹配：重新思考左心室肥厚DOI: 10.1016/j.jaccas.2026.109438 Journal of gastroenterology IF: 05.500Ahead of Print.No.139Tofogliflozin alters amino acid metabolism in gut microbiota linked to hepatic transcriptomic signatures in MASLD托格列净改变MASLD患者肠道微生物氨基酸代谢并与肝脏转录组特征相关DOI: 10.1007/s00535-026-02488-0 Frontiers in bioscience IF: 03.100Volume 31, Issue 7No.140Distinct Temporal Modulation of Mesenchymal Stem Cells and Empagliflozin on Renal c-Kit Cells in Diabetic Kidney Disease间充质干细胞与恩格列净对糖尿病肾病肾脏c-Kit细胞的不同时间调节DOI: 10.31083/FBL51501 Advances in therapy IF: 04.000Ahead of Print.No.141Diabetes Educators' Perspectives on MiniMed™ 780G Onboarding: Insights from a Multiregional Survey Across Europe, the Middle East, and Africa糖尿病教育者对MiniMed™ 780G上手的看法：来自欧洲、中东和非洲多区域调查的见解DOI: 10.1007/s12325-026-03716-y J Comput Aided Mol Des IF: 03.100Volume 40, Issue 1No.142Design of a metabolically-stable peptide therapeutic with triple-hormone-receptor agonist activity具有三重激素受体激动剂活性的代谢稳定肽治疗药物的设计DOI: 10.1007/s10822-026-00903-5 INT J NURS STUD ADV IF: 02.700Volume 11, Issue No.143A nurse-led perioperative intervention enhances self-care and supports long-term weight loss after bariatric surgery: a randomized controlled trial护士主导的围手术期干预增强减重手术后自我护理并支持长期减重：一项随机对照试验DOI: 10.1016/j.ijnsa.2026.100633 Rev Bras Med TrabVolume 24, Issue No.144Morphological profile and physical activity readiness among Portuguese police officers in the Lisbon metropolitan area里斯本大区葡萄牙警察的形态学特征与体力活动准备度DOI: 10.47626/1679-4435-2026-1544 Curēus IF: 01.300Volume 18, Issue 6No.145Predictive Performance of Hematological Parameters for Acute Respiratory Distress Syndrome in Hospitalized Pregnant and Postpartum Women With COVID-19血液学参数对住院妊娠及产后COVID-19女性急性呼吸窘迫综合征的预测性能DOI: 10.7759/cureus.111714 Curēus IF: 01.300Volume 18, Issue 7No.146Obstructive Sleep Apnea as a Modifiable Contributor to Chronic Pain in Rheumatologic Disease: The Potential Role of Continuous Positive Airway Pressure Therapy阻塞性睡眠呼吸暂停作为风湿性疾病中慢性疼痛的可调控因素：持续气道正压通气的潜在作用DOI: 10.7759/cureus.113582 Food science & nutrition IF: 03.800Volume 14, Issue 8No.147Effects of Araticum (Annona crassiflora Mart.) By-Product on Intestinal Health Parameters in High-Fat Diet-Fed Mice阿提库姆（Annona crassiflora Mart.）副产品对高脂饮食小鼠肠道健康参数的影响DOI: 10.1002/fsn3.72163 Journal of transport & health IF: 03.300Volume 50, Issue No.148Engaging Community Residents in Large-Scale Neighborhood Audits for Health Research让社区居民参与大规模健康研究中的邻里审计DOI: 10.1016/j.jth.2026.102362 J Nutr Metab IF: 02.400Volume 2026, Issue No.149The Relationship of Fatty Food Consumption, History of Disease, and Physical Activity With the Event of Adolescent Obesity in Indonesia高脂食物摄入、疾病史和体力活动与印度尼西亚青少年肥胖事件的关系DOI: 10.1155/jnme/2693160 Health science reports IF: 02.100Volume 9, Issue 8No.150A Spatial-Temporal Epidemiology of Anxiety Incidence Rates in Iran (2010-2021): An Ecological Study伊朗焦虑症发病率的时空流行病学研究（2010-2021）：一项生态学研究DOI: 10.1002/hsr2.72894 Food science & nutrition IF: 03.800Volume 14, Issue 8No.151Dose-Dependent Anti-Obesity and Protective Effects of Chia (Salvia hispanica L.) Seed Oil Against Hematological and Hepatorenal Dysfunction in High-Fat Diet-Fed Mice奇亚籽油对高脂饮食喂养小鼠的剂量依赖性抗肥胖及对血液和肝肾功能障碍的保护作用DOI: 10.1002/fsn3.72161 Front Glob Womens Health IF: 02.400Volume 7, Issue No.152Evaluating childbirth options for women with obesity: a multi-criteria decision analysis肥胖女性分娩方案评估：多准则决策分析DOI: 10.3389/fgwh.2026.1822385 Aesthet Surg J Open Forum IF: 01.900Volume 8, Issue No.153Risk Factors for Postoperative Complications After Superomedial Pedicle Reduction Mammaplasty上内侧蒂乳房缩小术后并发症的危险因素DOI: 10.1093/asjof/ojag141 Malays J Med Sci IF: 01.500Volume 32, Issue 6No.154Exploring Out-of-Pocket Costs and Health-Related Quality of Life among Patients with Cancer and Diabetes in Malaysia马来西亚癌症与糖尿病患者自付费用与健康相关生活质量研究DOI: 10.21315/mjms-07-2025-562 RSC medicinal chemistry IF: 03.600Ahead of Print.No.155Probing pyrazolo-pyrimidines as SIRT2 inhibitors via molecular modelling and biological assays通过分子建模和生物学测定探究吡唑并嘧啶类化合物作为SIRT2抑制剂DOI: 10.1039/d6md00144k Tobacco induced diseases IF: 01.900Volume 24, Issue No.156GLP-1 agonists for smoking cessation and post-cessation weight management: A systematic review and meta-analysis of randomized trialsGLP-1受体激动剂用于戒烟和戒烟后体重管理：随机试验的系统评价和荟萃分析DOI: 10.18332/tid/219815 Case Rep Oncol Med IF: 00.600Volume 2026, Issue No.157Ectopic Adrenocorticotropic Hormone Syndrome in a Patient Diagnosed With Lung Adenocarcinoma and Hospitalized Due to Diabetic Ketonuria: A Case Report一例因糖尿病酮尿症住院并诊断为肺腺癌的异位促肾上腺皮质激素综合征病例报告DOI: 10.1155/crom/6307000 Lancet Reg Health Eur IF: 13.000Volume 67, Issue No.158Corrigendum to 'Metabolic trajectories before diabetes diagnosis across subgroups: a pooled analysis of prospective European cohort studies' [The Lancet Regional Health-Europe volume 66 (2026) 1-11/101715]对《糖尿病诊断前不同亚组的代谢轨迹：欧洲前瞻性队列研究的汇总分析》的更正DOI: 10.1016/j.lanepe.2026.101793 SSM-QUAL RES HEALTH IF: 02.500Volume 10, Issue No.159Rental assistance impacts on diabetes: Insights from a longitudinal mixed-methods analysis租金援助对糖尿病的影响：来自纵向混合方法分析的见解DOI: 10.1016/j.ssmqr.2026.100817 Kidney medicine IF: 03.400Volume 8, Issue 8No.160New-Onset Heart Failure in Hemodialysis Patients: Association With Access Location and Access Flow in a Nationwide Cohort From Sweden血液透析患者新发心力衰竭与血管通路位置及血流量的关联：瑞典全国队列研究DOI: 10.1016/j.xkme.2026.101427 Front Behav Neurosci IF: 02.900Volume 20, Issue No.161Quality of life improvements with setmelanotide treatment in acquired hypothalamic obesity: TRANSCEND trial interview results from US participants塞美拉诺肽治疗获得性下丘脑肥胖的生活质量改善：TRANSCEND试验美国参与者访谈结果DOI: 10.3389/fnbeh.2026.1830070 Frontiers in medicine IF: 03.000Volume 13, Issue No.162Case report: Three contrasting presentations of acute oesophageal necrosis and the determinants of outcome病例报告：急性食管坏死的三种对比表现及预后决定因素DOI: 10.3389/fmed.2026.1882540 Br J Hosp Med (Lond) IF: 01.800Volume 87, Issue 7No.163Metformin: Not Just a Diabetes Treatment二甲双胍：不仅仅是糖尿病治疗药物DOI: 10.31083/BJHM54156 Frontiers in nephrologyVolume 6, Issue No.164Efficacy and safety of vitamin D supplementation in diabetic kidney disease: an umbrella review of systematic reviews and meta-analyses维生素D补充在糖尿病肾脏病中的有效性和安全性：系统评价与meta分析的伞状综述DOI: 10.3389/fneph.2026.1883351 Korean journal of anesthesiology IF: 06.300Ahead of Print.No.165Korean consensus-based recommendations for preanesthetic gastric ultrasound and anesthetic considerations for GLP-1 receptor agonist-based therapy: a consensus statement from Clinical Practice Guideline Committee of the Korean Society of Anesthesiologists基于韩国共识的麻醉前胃部超声检查及GLP-1受体激动剂治疗的麻醉考虑：韩国麻醉学会临床实践指南委员会共识声明DOI: 10.4097/kja.26655 Health science reports IF: 02.100Volume 9, Issue 8No.166Diminished Hepatitis B Antibody Response in Pediatrics With Type 1 Diabetes; the Need for Revaccination Protocol: A Case-Control Study1型糖尿病患儿乙型肝炎抗体反应减弱：再接种方案的必要性——一项病例对照研究DOI: 10.1002/hsr2.72700 Case Reports in Cardiology IF: 00.500Volume 2026, Issue No.167Heart Transplantation in Nonoperable Multiple Giant Coronary Artery Aneurysms: A Case Report心脏移植治疗不可手术的多发性巨大冠状动脉瘤：一例病例报告DOI: 10.1155/cric/9933683 JMIR formative research IF: 02.100Volume 10, Issue No.168Trauma-Informed Support in a Dementia Helpline: Retrospective Mixed Methods Study痴呆症求助热线中的创伤知情支持：回顾性混合方法研究DOI: 10.2196/71746 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.169Admission hyperglycemia, in-hospital glycemic management, and discharge outcomes in acute ischemic stroke: a UAE comprehensive stroke center cohort入院高血糖、院内血糖管理与急性缺血性卒中出院结局：阿联酋综合卒中中心队列研究DOI: 10.3389/fendo.2026.1887754 JCEM case reportsVolume 4, Issue 9No.170A rare case of an indolent giant GH-secreting pituitary adenoma一例惰性巨大生长激素分泌型垂体腺瘤罕见病例DOI: 10.1210/jcemcr/luag138 Research synthesis methods IF: 06.100Ahead of Print.No.171Incorporating estimands into meta-analyses of clinical trials将目标估计量纳入临床试验的荟萃分析DOI: 10.1017/rsm.2026.10107 Circ Popul Health OutcomesAhead of Print.No.172Comparison of Lipid Results From 2007 to 2009 via Commercial Clinical Laboratory Testing Versus a Population-Based Cohort: Proof-of-Concept for Population Health Monitoring of Lipids Using Commercial Lab Data2007年至2009年商业临床实验室检测与基于人群队列的脂质结果比较：使用商业实验室数据进行人群健康监测的概念验证DOI: 10.1161/CIRCOUTCOMES.126.013500 British journal of pharmacology IF: 07.700Ahead of Print.No.173Thirty-day dapagliflozin therapy improves the nanomechanical properties of red blood cells in patients with type 1 diabetes三十天达格列净治疗改善1型糖尿病患者红细胞的纳米力学特性DOI: 10.1111/bph.70613 Curēus IF: 01.300Volume 18, Issue 6No.174Efficacy and Safety of Dual and Triple Glucagon-Like Peptide-1-Based Polyagonists in Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Meta-Analysis双靶点和三靶点胰高血糖素样肽-1类多激动剂在代谢功能障碍相关脂肪性肝病和脂肪性肝炎中的有效性与安全性：系统评价与荟萃分析DOI: 10.7759/cureus.111728 Sleep AdvVolume 7, Issue 3No.175Sleep-AID: a cross-sectional analysis of subjective sleep quality, psychosocial measures and real-world glycemic outcomes in people with diabetes using automated insulin delivery systems睡眠-AID：使用自动化胰岛素输送系统的糖尿病患者主观睡眠质量、心理社会测量和真实世界血糖结果的横断面分析DOI: 10.1093/sleepadvances/zpag066 Malays J Med Sci IF: 01.500Volume 32, Issue 6No.176Building Trust in Generics and Biosimilar: Strengthening Regulatory Confidence在仿制药和生物类似药中建立信任：加强监管信心DOI: 10.21315/mjms-10-2025-s03 Frontiers in immunology IF: 05.900Volume 17, Issue No.177Interactions between betaine, insulin resistance, and cognitive impairment in people with and without HIV甜菜碱、胰岛素抵抗与认知障碍在HIV感染者与非感染者中的相互作用DOI: 10.3389/fimmu.2026.1878678 Food science & nutrition IF: 03.800Volume 14, Issue 8No.178Therapeutic Potential of Water-Based Anatolian Propolis Extract Against CAF Diet-Induced Obesity and Its Metabolic Complications水基安纳托利亚蜂胶提取物对抗CAF饮食诱导肥胖及其代谢并发症的治疗潜力DOI: 10.1002/fsn3.72160 Frontiers in endocrinology IF: 04.600Volume 17, Issue No.179Improvement in insulin injection timing and glucometrics using a connected insulin cap: the Insulclock v2.0® prospective study使用连接胰岛素笔帽改善胰岛素注射时机和血糖指标：Insulclock v2.0®前瞻性研究DOI: 10.3389/fendo.2026.1883791 Cancer reports IF: 01.900Volume 9, Issue 8No.180Impact of Metformin Use on Clinical and Pathological Outcomes in Breast Cancer Patients With Type 2 Diabetes二甲双胍使用对合并2型糖尿病的乳腺癌患者临床和病理结局的影响DOI: 10.1002/cnr2.70631 The Egyptian Heart Journal IF: 01.400Volume 78, Issue 1No.181Predictors of atrial fibrillation recurrence after catheter ablation: a systematic review导管消融术后房颤复发的预测因素：一项系统综述DOI: 10.1186/s43044-026-00765-0 Curēus IF: 01.300Volume 18, Issue 6No.182An Unusual Case of Thrombocytopenia and Renal Failure Revealing Malignancy-Associated Thrombotic Microangiopathy一例以血小板减少和肾衰竭为表现的恶性肿瘤相关血栓性微血管病罕见病例DOI: 10.7759/cureus.111732 Obesity pillarsVolume 19, Issue No.183Nutritional considerations for glucagon-like peptide-based therapies: An Asian Indian consensus recommendation基于胰高血糖素样肽的疗法的营养考量：一项亚洲印度共识建议DOI: 10.1016/j.obpill.2026.100296 J Nutr Metab IF: 02.400Volume 2026, Issue No.184An 8-Week Triple-Blind, Randomized, Placebo-Controlled Trial Evaluating High-Dose Vitamin D3 and Flaxseed Oil for Inflammation and Metabolic Health in Elderly Patients With Type 2 Diabetes: Implications for Clinical Management高剂量维生素D3和亚麻籽油对老年2型糖尿病患者炎症和代谢健康的影响：一项为期8周的三盲随机安慰剂对照试验及其临床管理意义DOI: 10.1155/jnme/8892400 Curēus IF: 01.300Volume 18, Issue 6No.185Comparative Cardiovascular Outcomes and Safety Profiles of Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Trials胰高血糖素样肽-1受体激动剂在2型糖尿病中的心血管结局与安全性比较：随机试验的系统评价与荟萃分析DOI: 10.7759/cureus.111723 Journal of ophthalmology IF: 01.900Volume 2026, Issue No.186Dysregulation of the Glycolytic Entry Gate and Survival Route by Advanced Lipoxidation End Products in Diabetes Mellitus晚期脂氧化终产物对糖尿病中糖酵解入口和生存通路的失调DOI: 10.1155/joph/8316457 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.187Quantitative and preliminary clinical assessment of glycohypoxia as an oxygen-unloading defect linking chronic hyperglycemia to low-grade tissue hypoxia in type 2 diabetes: a targeted translational meta-regression with exploratory blood-sample validation糖缺氧作为连接慢性高血糖与2型糖尿病低度组织缺氧的氧卸载缺陷的定量及初步临床评估：一项靶向转化性Meta回归及探索性血样验证DOI: 10.3389/fcdhc.2026.1897413 Front Artif Intell IF: 04.700Volume 9, Issue No.188Machine learning algorithms for predicting glycemic control and weight loss outcomes in GLP-1 receptor agonist users机器学习算法预测GLP-1受体激动剂使用者血糖控制和减重结局DOI: 10.3389/frai.2026.1861563 Clin Psychopharmacol Neurosci IF: 02.700Volume 24, Issue 3No.189Neurovascular Actions of Dipeptidyl Peptidase-4 Inhibitors and Their Implications for Cognitive Dysfunction in Type 2 Diabetes Mellitus二肽基肽酶-4抑制剂的神经血管作用及其对2型糖尿病认知功能障碍的影响DOI: 10.9758/cpn.26.1403 Current Cardiology Reports IF: 03.300Volume 28, Issue 1No.190Heart Failure with Preserved Ejection Fraction in Women: Sex-Specific Insights Across the Continuum from Diagnosis to Outcomes女性射血分数保留的心力衰竭：从诊断到结局的性别特异性见解DOI: 10.1007/s11886-026-02392-2 J Dev Orig Health Dis IF: 01.500Volume 17, Issue No.191The maternal microbiome-epigenome axis in gestational diabetes: pathogenesis, diagnosis, and emerging therapies妊娠期糖尿病中的母体微生物组-表观基因组轴：发病机制、诊断与新兴疗法DOI: 10.1017/S2040174426100695 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.192Is maternal diabetes associated with autism spectrum disorder and ADHD in the offspring? A short review母亲糖尿病与后代自闭症谱系障碍和注意缺陷多动障碍相关吗？一项简短综述DOI: 10.3389/fcdhc.2026.1855251 Paediatr Perinat Epidemiol IF: 02.500Ahead of Print.No.193Choice of Growth Standard and Interpretation of Large for Gestational Age Outcomes: Evidence From the CDC4G Trial生长标准选择与大于胎龄儿结局解读：来自CDC4G试验的证据DOI: 10.1111/ppe.70180 Optometry and vision science IF: 01.800Volume 103, Issue 8No.194Case series: The role of retinal ischemia in the pathogenesis and clinical manifestation of diabetic retinopathy病例系列：视网膜缺血在糖尿病视网膜病变发病机制和临床表现中的作用DOI: 10.1002/ovs2.70090 Front Clin Diabetes Healthc IF: 02.200Volume 7, Issue No.195Correction: Neuropathy predicts early renal impairment in diabetes mellitus-the almost forgotten historical evidence. In memoriam Professor Göran Sundkvist更正：神经病变预测糖尿病早期肾功能损害——几乎被遗忘的历史证据。纪念Göran Sundkvist教授DOI: 10.3389/fcdhc.2026.1918820 177 Diabetes Mellitus(DM) 糖尿病 85 Obesity 肥胖症 55 Insulin 胰岛素 23 Type 2 diabetes mellitus(T2DM) 2型糖尿病 15 Diabetic Retinopathy 糖尿病视网膜病 12 Metformin 二甲双胍 10 Glucagon-Like Peptide-1 Receptor Agonists(GLP-1RA) 胰高血糖素样肽-1受体激动剂 9 Metabolic Syndrome 代谢综合征 7 Gestational Diabetes Mellitus(GDM) 妊娠糖尿病 7 Tirzepatide 替尔泊肽 7 Diabetic Kidney Disease(DKD) 糖尿病肾脏病 5 Diabetic Foot 糖尿病足 5 Hypoglycemic Agents 降糖药 4 Semaglutide 司美格鲁肽 4 Dapagliflozin 达格列净 4 Type 1 diabetes mellitus(T1DM) 1型糖尿病 3 Diabetic acidosis 糖尿病性酸中毒 3 gamma-Aminobutyric Acid(GABA) γ-氨基丁酸 2 Sodium-Glucose Transporter 2 Inhibitors(SGLT-2i) 钠-葡萄糖协同转运蛋白2抑制剂 2 Diabetic Neuropathies 糖尿病性神经病变 2 Empagliflozin 恩格列净 1 Tofogliflozin 托格列净 1 Diabetes Complications 糖尿病并发症 1 Dulaglutide 度拉糖肽 1 Liraglutide 利拉鲁肽 1 Dipeptidyl-Peptidase IV Inhibitors(DPP-4i) 二肽基肽酶-4抑制剂 1 Gastrointestinal lipase inhibitor 胃肠道脂肪酶抑制剂 1 Orlistat 奥利司他 1 Diabetic Angiopathies 糖尿病血管病变 1 Diabetic Cardiomyopathies 糖尿病心肌病 1 Alzheimer Disease and Diabetes Mellitus 阿尔茨海默病与糖尿病编辑：韩玉莲审校：韩玉莲

2026-07-31

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医药细分赛道怎么选？聚焦三高、心血管核心方向

最近不少朋友私信问我，医药板块来回震荡，五花八门的细分赛道看得眼花缭乱，创新药、器械、CXO轮番炒作，到底哪些方向能够拿得住、逻辑够硬。我这段时间反复复盘各个赛道的数据，慢慢形成一个很清晰的想法：比起那些博弈临床数据、高度依赖海外订单的赛道，慢病领域值得沉下心持续跟踪。尤其是高血压、心脏疾病、糖尿病，也就是大家常说的三高与心血管赛道。很多人会下意识觉得，慢病药物大多是仿制药，常年面临集采压力，很难走出大行情。说实话，早些年我也是这么认为。但这两年走访行业、持续跟踪终端销售数据之后，我的看法发生了很大转变。我们不能用几年前的旧思维，简单给整个赛道下定义。想要看懂机会，首先要看懂底层需求。先聊最朴素的现实。高血压、心衰、糖尿病这类慢性病，现阶段医疗水平无法彻底根治，确诊之后，绝大多数患者需要终身服药控制指标，防止心梗、脑梗、肾衰竭、眼底病变等致命并发症。这种需求，是实打实的刚性复购。感冒用药是一次性消费，手术用药是阶段性需求，而慢病药物，相当于患者长期固定的医疗支出。再叠加国内老龄化持续推进。国内60岁以上人口体量持续走高，中老年群体当中三高患病率超过半数。不止老年人，现在年轻人熬夜、饮食重油重糖、缺乏运动，高血压、糖耐异常的人群逐年增多，患病群体正在不断扩大。患者基数只会持续扩张，赛道长期的需求底座不会消失。我对比过各大医药细分板块的业绩波动。肿瘤创新药，高度押注临床试验结果，一旦三期数据不及预期，企业估值会直接承压；CXO容易受到海外资本开支、汇率波动影响；而优质慢病药企，依靠成熟大单品形成稳定现金流。即便集采带来降价压力，庞大的患者基数可以推动销量提升，部分企业能够实现“价减量增”，业绩波动相比题材型药企平缓很多。当然，这并不代表赛道没有风险，只是博弈的逻辑完全不同。政策层面的变化，也值得我们认真留意。近几年门诊慢特病政策持续优化，多地延长高血压、糖尿病长期处方周期，简化慢病患者开药流程，医保持续完善慢特病报销机制。基层社区医疗机构逐步配齐慢病常用药物，处方外流持续推进，零售药店、线上医药渠道不断扩容。过去药品销售高度依赖公立医院，现在院外市场正在成为慢病药企新的增长空间。不过这里我想说一句心里话，政策是双刃剑。集采常态化不会停下脚步，这是所有参与慢病赛道的投资者必须放在第一位的前提。指望仿制药维持过去高毛利时代的红利，本身就不现实。集采环境下，赛道内部会持续分化，单纯依靠仿制药、缺乏创新管线的企业，长期利润天花板会不断压缩。真正能够穿越周期的公司，一定是手握创新品种、拥有差异化临床价值的玩家。接下来分开聊聊三大细分方向各自的机会与难点，我尽量说得通俗，不堆砌晦涩的专业名词。先说高血压赛道。国内高血压患者群体规模庞大，但有一个很突出的现状：规范化治疗比例并不高，很多人血压升高之后没有持续服药，指标控制不达标的人群占比很高。传统降压药品类繁多，市场竞争非常激烈，普利类、沙坦类老牌药物大多已经纳入集采，价格竞争白热化，很难再出现高增长。所以单纯布局传统仿制药，性价比不高。这条赛道真正值得关注的，是新一代降压药物。 ARNI类药物是最近几年心血管领域的热门品种，这类药物不止单纯降压，同时能够保护心脏、肾脏，尤其适合高血压合并心衰、糖尿病肾病的共病患者，临床指南推荐等级持续提升。目前外资原研产品占据主要市场份额，随着国产创新品种陆续落地，赛道格局会慢慢发生变化。另外，国内高血压人群当中，合并高尿酸、高血脂的比例很高，能够兼顾多种并发症、复方制剂、长效制剂，在临床上具备天然优势。很多中老年患者同时吃五六种药，如果一款药物能够实现联合管控，患者用药依从性会明显提升。这也是药企研发的重要方向。我自己观察下来，高血压赛道的投资难点在于市场过于分散。单品想要实现持续高增长难度不小，选股的时候，不能只看一款降压药，要看企业是否形成心血管产品矩阵，能不能在心衰、肾病等相关领域协同拓展。再说说心脏病赛道，重点聚焦慢性心衰。很多人容易把心血管赛道笼统混在一起，冠心病、心律失常、心衰，看似接近，市场逻辑差异巨大。急性心脏病依靠手术、介入器械，而慢性心衰属于长期慢病管理。心衰属于各类心血管疾病的终末期，死亡率偏高，治疗负担很重。大量高血压、糖尿病患者，长期控制不佳，最终都会进展为心衰。市场长期存在未被满足的临床需求。 SGLT2抑制剂原本是降糖药，后续适应症拓展到心衰，算是近几年医药领域非常重要的突破。不管患者有没有糖尿病，这类药物都能够降低心衰住院风险，现在已经成为国内外心衰诊疗指南一线推荐用药。这也带来一个很有意思的变化：糖尿病赛道和心衰赛道边界慢慢融合，不少药物实现跨病种适应症拓展。心衰赛道还有一个特点，新药临床转化周期很长，研发门槛高。能够成功做出心衰创新药的企业，护城河相对更深。风险点同样清晰：新药研发失败概率不低，前期投入巨大，一旦临床数据不及预期，投入很难收回。同时，热门品种未来同样存在纳入集采的可能性。最后聊市场热度最高的糖尿病赛道。很多人提起糖尿病，第一反应就是GLP-1系列产品，降糖、减重双重属性，这两年资本市场关注度居高不下。客观承认，GLP-1赛道确实具备想象力。从单纯治疗二型糖尿病，逐步拓展至肥胖、慢性肾病、非酒精性脂肪肝等多个适应症，市场空间持续打开。海外药企产品已经验证商业化潜力，国内多家企业布局同类产品，从生物类似药，到单靶点、双靶点、三靶点创新分子，管线布局十分拥挤。但我必须提醒大家，热度越高，越容易产生预期差。现在市场已经提前透支不少乐观预期，未来大量国产同类产品陆续获批之后，激烈价格竞争几乎是必然发生的。不要简单认为，只要布局GLP-1，企业就能稳定盈利。口服制剂、长效剂型、差异化适应症布局，会成为企业拉开差距的关键。除了GLP-1，传统降糖赛道同样不能忽视。基础胰岛素、新型SGLT2抑制剂，依旧是糖尿病治疗的基石用药。基层市场当中，大量中老年患者更倾向选择成熟、价格亲民的基础降糖药物。很多企业依靠胰岛素产品稳住基本盘，再投入创新药研发，形成攻守兼备的产品结构。糖尿病并发症市场同样容易被忽略。糖尿病肾病、糖尿病眼底病变、周围神经病变，病程拉长之后并发症陆续出现，对应的治疗药物需求稳步增长。这块细分赛道竞争没有主流降糖药那么内卷，具备长期挖掘价值。把三大赛道梳理完，再聊聊我筛选企业时，一直在坚守的几条标准，也是用来避开大部分陷阱的思路。第一，区分仿制药与创新药的估值逻辑。已经经历集采、完成价格消化的成熟仿制药品种，优势在于业绩稳定性强，适合偏长期布局；尚未纳入集采、当前利润丰厚的品种，反而暗藏不确定性，政策风险随时可能落地。单纯依靠单一仿制药大单品的企业，需要多一份谨慎。第二，重视管线梯队，拒绝“单品依赖”。慢病药物就算生命周期很长，也无法永远依靠一款药品持续增长。优质企业需要做到：成熟品种贡献稳定现金流，处于推广期的创新品种承接增长，临床阶段管线储备未来增长点。如果一家公司所有业绩都押在一款产品上，容错率太低。第三，区分临床价值和概念炒作。现在很多药企公布管线，就容易引发资金短期炒作。大家要学会区分，管线是真正具备差异化临床优势，还是单纯跟随热门靶点跟风研发。同样靶点的药物，给药频率、副作用、适用人群的细微差距，最终会带来商业化结果天差地别。第四，重视渠道能力。慢病药物很大一部分增量来自院外零售市场。同样一款药品，有的企业院内、连锁药店、线上渠道同步推进，放量速度更快；只依靠公立医院渠道的药企，增长空间会受到限制。营销渠道、学术推广能力，很容易被散户忽略，但真实影响药品最终销量。聊完机会，风险我也不回避，全部摊开来讲，保持客观。首要风险依旧是药品集采常态化。未来三高领域主流慢病药物，大概率会逐步纳入集采范围，降价压力长期存在。就算集采规则持续优化，缓和极端降价幅度，药企也要接受药品毛利率下行的大趋势。其次是创新研发风险。慢病创新药研发周期动辄数年，投入资金规模巨大，二期临床效果不错，三期试验失败的案例比比皆是，巨额研发投入有可能全部沉没。还有竞争加剧的风险。GLP-1、新一代ARNI这类热门赛道，涌入大量玩家，未来产品集中上市之后，同质化竞争会快速压缩盈利空间。外资原研药企也会持续推进新一代产品迭代，国产创新药始终要直面跨国巨头的竞争。另外，居民就医、用药需求的恢复节奏，基层慢病规范化诊疗推进速度，都会间接影响药品放量进度，这些属于中长期变量，很难精准预判。不少朋友问我，下半年能不能直接重仓这条赛道。我没法给出肯定答案，每个人风险承受能力、持仓周期完全不一样。我只能说，三高与心血管慢病赛道，是医药板块当中少数需求逻辑长期稳固的方向，适合愿意耐心跟踪、以中长期视角布局的人。追求短期连续暴涨的资金，这条赛道大概率很难满足预期。市场永远不会缺少热点，题材轮动此起彼伏。很多资金热衷于追逐短期爆发的赛道，但是潮水退去之后，能够持续稳定创造现金流的企业终究是少数。老龄化催生的慢病需求，不会因为市场情绪起伏突然消失。沉下心，把细分赛道竞争格局、企业产品管线、政策变量研究透彻，远比跟风炒作概念更加重要。赛道选对只是第一步，后续还要持续跟踪药品准入、终端销售数据、研发临床进展，动态调整判断，不能买入之后就置之不理。写到这里，我也想听听大家的想法：你觉得三高慢病赛道，最大的不确定性是什么？是集采压力，还是赛道内部越来越激烈的同质化竞争？欢迎在评论区一起交流探讨。免责声明本文仅为行业信息客观梳理、个人观点分享，不构成任何投资建议。文中提及行业内容仅供参考，股市存在较高风险，请各位读者独立决策、理性投资。

2026-07-30

·搜狐新闻

GLP-1减肥药背后的技术推手

当‘打一针瘦十斤’的新闻刷屏朋友圈，当司美格鲁肽从糖尿病药摇身变成全球抢购的‘瘦身神器’，你有没有想过：这些改变体型的分子，究竟是怎么从实验室烧杯里，一步步走向注射笔和药房柜台的？不是药厂，却比药厂更早摸到分子的脉搏答案藏在一条常被忽略的产业链上游——CRO（合同研究组织）。它们不贴牌、不卖药、不喊口号，却握着新药研发最关键的‘手’：设计分子、优化结构、验证机制、闯关毒理。泓博医药，正是这样一家沉默却高频运转的‘分子建筑师’。它不生产GLP-1类药物，但可能亲手帮三家公司把同一类靶点的候选分子，从IC50值不稳定的状态，调教成具备口服潜力的前药；它不宣布临床数据，却在动物模型中反复测试不同酰化链长度对半衰期的影响——这些细节，恰恰决定了一款减肥药是‘打一周停两周’，还是‘每月一针管一月’。 GLP-1不是魔法，而是一场精密的‘分子驯化’ 很多人以为GLP-1类药物的原理很‘直给’：激活肠道和大脑里的受体，让人吃得少、耗得多。但现实远比这复杂。天然GLP-1在体内仅存活2分钟，会被DPP-4酶瞬间剪断。真正的技术门槛，不在‘找靶点’，而在‘护住它’——用脂肪酸链‘伪装’它，用氨基酸替换‘加固’它，用聚合物‘缓释’它。这些改造，90%发生在临床前阶段，而CRO公司，就是这场‘分子驯化’的首席驯兽师。泓博医药所言‘丰富的技术服务能力’，正体现在这里：它能同步推进多条技术路径——长效化修饰、口服递送系统、双靶点融合蛋白设计。这不是堆人力，而是靠多年积累的‘结构-活性-代谢’数据库与自动化筛选平台。一个项目背后，可能是37轮构效关系迭代、217种制剂配方试错、48只食蟹猴的精准药代追踪。保密协议不是遮羞布，而是产业成熟的勋章当被问及具体客户或进度，泓博回应‘因保密协议无法透露’——这话听着像标准话术，实则暗含深意。真正值得警惕的，是那些高调晒管线、却连CMC（化学工艺开发）都外包给第三家公司的‘故事型药企’；而选择沉默的CRO，往往已深度嵌入客户的GMP生产节奏，甚至参与申报资料的原始数据生成。保密，恰说明合作已进入高价值、高敏感阶段：不是还在画饼，而是正在填表。在这个时代，一款爆款减肥药的诞生，早已不是单点突破，而是一张横跨上海实验室、苏州中试车间、爱尔兰灌装线的协作网络。泓博医药站在网眼中央，不露脸，但每一根丝线，都带着它的温度与刻度。所以，下次再看到‘GLP-1’三个字母，不妨多想一秒：它不只是激素名，更是一组被反复计算、修饰、验证、保护的化学密码——而解码的人，正安静地，在实验记录本第382页写下新的溶剂配比。返回搜狐，查看更多

100 项与 Glucagon-Like-Peptide-1(Original Biomedicals) 相关的药物交易

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